Recent Insights and Applications of Nanocarriers-Based Drug Delivery Systems for Colonic Drug Delivery and Cancer Therapy: An Updated Review

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104646 - 104646

Опубликована: Фев. 1, 2025

Язык: Английский

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Preparation of pH-enzyme dual-responsive gel microspheres and their treatment of ulcerative colitis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141567 - 141567

Опубликована: Фев. 27, 2025

Язык: Английский

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Protein/polysaccharide based oral delivery system for precise targeting of polyphenols and carotenoids

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105311 - 105311

Опубликована: Окт. 1, 2024

Язык: Английский

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Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер unknown, С. 1 - 23

Опубликована: Окт. 12, 2023

AbstractPolyphenols have received considerable attention for their promotive effects on colonic health. However, polyphenols are mostly sensitive to harsh gastrointestinal environments, thus, must be protected. It is necessary design and develop a colon-targeted delivery system improve the stability, colon-targeting bioavailability of polyphenols. This paper mainly introduces research controlled release The physiological features affecting dissolution, absorption polyphenol-loaded systems in colon first discussed. Simultaneously, types carriers with different mechanisms described, assessment models that been studied so far advantages limitations summarized. Based current colon-targeting, outlook reflections proposed, goal inspiring strategic development new therapeutics ensure reach complete bioactivity.Keywords: Colonic targetingpolyphenolscontrolled releaseconstruction principlesdelivery Authors' contributionsYidi Wang: Conceptualization-Equal, Data curation-Equal, Investigation-Equal, Writing – original draft; Zhiying Li: Formal analysis; Yiwen Bao: Investigation-Equal; Huijun Cui: Project administration-Equal; Jiaxin Methodology-Equal; Xingyue Resources-Equal; Mengzhu Baoge Song: Methodology-Equal, Haikun Yi Chen: Resources-Equal, Supervision-Equal; WeiChen: administration-Equal, Shufang Yang: Yiyun Zhufeng Jin: Xu Si: Funding acquisition-Equal, Software, Supervision-Equal, Validation, review & editing; Bin Supervision-Equal.Disclosure statementNo potential conflict interest was reported by author(s).Additional informationFundingThis work supported National Natural Science Foundation China [U21A20273], Central Government-guided local Technology Fund [2023JH6/100500010] Scientific Research Projects Liaoning Province [LSNQN202010].

Язык: Английский

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Exploration of the formative mechanisms of colon-targeting composite particles of natural products prepared via mechanical dry particle coating

Advanced Powder Technology, Год журнала: 2024, Номер 35(11), С. 104648 - 104648

Опубликована: Сен. 30, 2024

Язык: Английский

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Construction of biopolymer-based hydrogel beads for encapsulation, retention, and colonic delivery of tributyrin: Development of functional beverages (fortified bubble tea)

Food Research International, Год журнала: 2024, Номер 197, С. 115165 - 115165

Опубликована: Сен. 30, 2024

Язык: Английский

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Construction and characterization of a novel Myr-OSADS-CIn micelle for enhanced stability and bioavailability of myricetin

Food Bioscience, Год журнала: 2024, Номер 60, С. 104287 - 104287

Опубликована: Май 7, 2024

Язык: Английский

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Oral responsive delivery systems for probiotics targeting the intestinal tract

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract The increasing prevalence of health issues, driven by sedentary lifestyles and unhealthy diets in modern society, has led to a growing demand for natural dietary supplements support overall well‐being. Probiotic have garnered widespread recognition their potential benefits. However, efficacy is often hindered the hostile conditions gastrointestinal tract. To surmount this challenge, biomaterial‐based microencapsulation techniques been extensively employed shield probiotics from harsh environments stomach acid bile salts, facilitating precise delivery colon optimal nutritional effects. With consideration distinctive tract milieu, probiotic systems categorized into pH‐responsive release, enzyme‐responsive redox‐responsive release pressure‐triggered systems. These responsive not only demonstrated improved survival rates stomach, but also successful intestines, enhanced adhesion colonization within gut. Consequently, these contribute effectiveness supplementation intervening with diseases. This review provides comprehensive overview diverse oral tailored targeting intestinal Furthermore, critically examines limitations future prospects approaches. offers valuable guidance effective tract, enhancing as promote © 2024 Society Chemical Industry.

Язык: Английский

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Development and evaluation of innovative enteric-coated capsules for colon-specific delivery of hydrophilic biomaterials

International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124991 - 124991

Опубликована: Ноя. 1, 2024

Язык: Английский

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Advances in prebiotic carbohydrate–based targeted delivery: Overcoming gastrointestinal challenges for bioactive ingredients

Food Chemistry, Год журнала: 2024, Номер 466, С. 142210 - 142210

Опубликована: Ноя. 26, 2024

Язык: Английский

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