The Effects of Microplastics on Musculoskeletal Disorder; A Narrative Review DOI Creative Commons

Hiroyori Fusagawa,

Alex Youn,

Elyse Wilkerson

и другие.

Current Reviews in Musculoskeletal Medicine, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Purpose of Review The physical health impacts microplastics have received increasing attention in recent years. However, limited data impedes a full understanding the internal exposure to microplastics, especially concerning musculoskeletal system. purpose this review is summarize literature regarding effects on Recent Findings Microplastics been shown cause abnormal endochondral ossification and disrupt normal function pre-osteoblasts, osteocyte-like cells, pre-osteoclasts through gene mutations, endoplasmic reticulum stress induction, reduced autophagosome formation bone growth areas. Although there are few reports their muscle, it has noted that inhibit energy lipid metabolism, decrease type I muscle fiber density, impair angiogenesis, atrophy, increase deposition. Summary Only studies interfere with growth-related cells reduce mass quality. This underscores need for further research into other parts system using human tissues at disease level.

Язык: Английский

Emamectin Benzoate and Microplastics Led to Skeletal Muscle Atrophy in Common Carp via Induced Oxidative Stress, Mitochondrial Dysfunction, and Protein Synthesis and Degradation Imbalance DOI
Wenying Sun, Jing Liu, Xu Shi

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Pesticides and plastics have brought convenience to agricultural production daily life, but they also led environmental pollution through residual chemicals. Emamectin benzoate (EMB) is among the most widely used insecticides, which can cause harm health of organisms. Additionally, microplastics (MPs), a relatively new type pollutant, not only are increasing in amounts within water bodies aquatic organisms exacerbate by adsorbing other pollutants, leading mixed scenario. Nevertheless, toxicity mechanism EMB MPs on common carp skeletal muscle been elucidated. Therefore, we established exposure models for MPs, methods such as hematoxylin eosin staining, immunofluorescence JC-1 western blotting were employed investigate underlying mechanisms damage. The results vivo vitro experiments indicated that or oxidative stress, turn caused mitochondrial fusion/fission imbalance (with decreased Mfn1, Mfn2, OPA1 increased DRP1), reduced membrane potential, ATP content, protein synthesis, degradation, ultimately resulting atrophy. Joint more severe damage than single exposure, addition NAC effectively alleviate In summary, and/or induced excessive reactive oxygen species (ROS) production, giving rise dysfunction an synthesis atrophy carp.

Язык: Английский

Процитировано

4
Influence of selected dosages of plastic microparticles on the porcine fecal microbiome DOI Creative Commons
Ismena Gałęcka, Andrzej Rychlik, Jarosław Całka

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 8, 2025

Abstract Studies conducted so far have shown that nano- and microplastic may disturb the intestinal microenvironment by interacting with epithelium gut microbiota. Depending on research model used, effect microbiome is different—an increase or decrease in selected taxa resulting development of dysbiosis. Dysbiosis be associated inflammation, mental disorders diabetes. The aim study was to analyze 15 gilts divided into 3 groups (n = 5; control group, receiving micropartices at a dose 0.1 g/day (LD) 1 (HD)). Feaces were collected before after 28 days exposure PET microplastics. analysis performed using next-generation sequencing. Alpha beta diversity indices compared, showing, repetition affected only abundance LD groups, but not HD group. relationships between number reads phylum, genus species level calculated statistical methods ( r -Pearson correlation, generalized regression model, variance). revealed, populations Family XIII AD3011 group , Coprococcus V9D2013 UCG-010 Sphaerochaeta increased increasing MP-PET dose. above-mentioned are mainly responsible for production short-chain fatty acids (SCFA). It assumed, SCFA one mechanisms involved response oral MP-PET.

Язык: Английский

Процитировано

1
Exploring sustainable strategies for mitigating microplastic contamination in soil, water, and the food chain: A comprehensive analysis DOI Creative Commons

Udaratta Bhattacharjee,

Khanindram Baruah, Maulin P. Shah

и другие.

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy DOI Creative Commons
Yixuan Zhu,

Kaizhi Cai,

Lijuan Guo

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 19, 2025

To investigate whether Thrombospondin-1 (TSP-1) induces immunogenic cell death (ICD) in human mucoepidermoid carcinoma (MC-3) cells and explore its potential to induce calreticulin (CRT) exposure via the PERK/eIF2α signaling pathway. The MC-3 line was used as research model. CCK-8 assay performed determine optimal seeding density, TSP-1 concentration, treatment time. Annexin V/PI double staining combined with flow cytometry assess apoptosis across different experimental groups (blank control, TSP-1, paclitaxel (PTX), + PTX). Cells were divided into groups: blank PTX, ISRIB (ISRIB: Integrated Stress Response Inhibitor), CRT expression detected by cytometry. Immunofluorescence, Western blot, qPCR detect of PERK (Protein Kinase R-like Endoplasmic Reticulum Kinase), eIF2α (eukaryotic Initiation Factor 2α), CRT. All experiments triplicate, data analyzed using GraphPad Prism 8.0 software. Statistical significance set at P < 0.05. At a density 2 × 104/mL, reached growth plateau day six. concentration duration 0.1 μmol/L 72 h, respectively. Flow cytometry, immunofluorescence, results revealed that significantly induced (P 0.05), accompanied upregulation 0.05). Co-treatment PTX further enhanced these effects, while addition reduced PERK, eIF2α, ICD cells, exposure, potentially mediated through activation These findings suggest may have an adjunct chemotherapy for enhancing tumor immunotherapy.

Язык: Английский

Процитировано

0
Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway DOI

Dongbin Zou,

Yun Seok Yang, Fengjie Ji

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(30), С. 16638 - 16650

Опубликована: Июль 16, 2024

Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible pathogens develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, air, have unknown effects on development of infants. This study explored impact polystyrene MPs using a piglet model. Piglets control group received basal diet, those experimental groups diet contaminated with 150 mg/kg MPs. The results showed that exposure increased diarrhea incidence impaired function piglets. Notably, led oxidative stress inflammation intestine. Furthermore, MPs-treated piglets reduced level angiogenesis. Mechanistically, suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors' mRNA hindering In summary, contamination increases compromises angiogenesis through ROS/METTL3 pathway, demonstrating their toxic intestine health

Язык: Английский

Процитировано

3
Microplastic and the Enteric Nervous System: Effect of PET Microparticles on Selected Neurotransmitters and Cytokines in the Porcine Ileum DOI Open Access
Ismena Gałęcka, Jarosław Całka

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11645 - 11645

Опубликована: Окт. 30, 2024

Microplastic is an environmental hazard to which both animals and humans are exposed. Current reports show that it can cause inflammation, including in the gastrointestinal tract. To examine impact on ileum, 15 eight-week-old gilts (five individuals/group) were exposed PET microplastics (7.6 µm-416.9 µm) at a dose of 0.1 g/day or 1 for 28 days. The collected ileum fragments investigated cytokine concentrations (IL-1β, IL-6, IL-8, IL-10, TNF-α; ELISA test), neuron populations (cocaine amphetamine-regulated transcript, galanin, neuronal nitric oxide synthase, substance P, vesicular acetylcholine transporter, vasoactive intestinal peptide; immunofluorescence staining), morphometric parameters (histological analysis). Under influence MP-PET, there was reduction CART- GAL-positive neurons submucosal plexuses nNOS-, VAChT-, VIP-positive all plexuses. In contrast, increase myenteric plexus SP-positive IL-1β, TNF-α did not undergo statistically significant changes under low high MP-PET. histological structure exclusively concerned thinning mucosa muscularis externa. results support thesis MP-PET neutral ileal cells.

Язык: Английский

Процитировано

0
The Effects of Microplastics on Musculoskeletal Disorder; A Narrative Review DOI Creative Commons

Hiroyori Fusagawa,

Alex Youn,

Elyse Wilkerson

и другие.

Current Reviews in Musculoskeletal Medicine, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Purpose of Review The physical health impacts microplastics have received increasing attention in recent years. However, limited data impedes a full understanding the internal exposure to microplastics, especially concerning musculoskeletal system. purpose this review is summarize literature regarding effects on Recent Findings Microplastics been shown cause abnormal endochondral ossification and disrupt normal function pre-osteoblasts, osteocyte-like cells, pre-osteoclasts through gene mutations, endoplasmic reticulum stress induction, reduced autophagosome formation bone growth areas. Although there are few reports their muscle, it has noted that inhibit energy lipid metabolism, decrease type I muscle fiber density, impair angiogenesis, atrophy, increase deposition. Summary Only studies interfere with growth-related cells reduce mass quality. This underscores need for further research into other parts system using human tissues at disease level.

Язык: Английский

Процитировано

0