The role of mitochondrial quality surveillance in skin aging: Focus on mitochondrial dynamics, biogenesis and mitophagy

Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101917 - 101917

Опубликована: Март 25, 2023

Язык: Английский

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Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2023, Номер 1869(7), С. 166798 - 166798

Опубликована: Июнь 29, 2023

Язык: Английский

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An Approach toward Artificial Intelligence Alzheimer’s Disease Diagnosis Using Brain Signals

Diagnostics, Год журнала: 2023, Номер 13(3), С. 477 - 477

Опубликована: Янв. 28, 2023

Background: Electroencephalography (EEG) signal analysis is a rapid, low-cost, and practical method for diagnosing the early stages of dementia, including mild cognitive impairment (MCI) Alzheimer’s disease (AD). The extraction appropriate biomarkers to assess subject’s has attracted lot attention in recent years. aberrant progression AD leads cortical detachment. Due interaction several brain areas, these disconnections may show up as abnormalities functional connectivity complicated behaviors. Methods: This work suggests novel differentiating between AD, MCI, HC two-class three-class classifications based on EEG signals. To solve class imbalance, we employ data augmentation techniques, such repeating minority classes using variational autoencoders (VAEs), well traditional noise-addition methods hybrid approaches. power spectrum density (PSD) temporal employed this study’s feature from signals were combined, support vector machine (SVM) classifier was used distinguish three categories problems. Results: Insufficient unbalanced datasets are two common problems datasets. study shown that it possible generate comparable noise addition VAE, train model data, and, some extent, overcome aforementioned issues with an increase classification accuracy 2 7%. Conclusion: In work, able successfully detect classes: HC. comparison pre-augmentation stage, gained increased by 3% when VAE added additional data. As result, clear how useful smaller sample numbers.

Язык: Английский

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Mitochondria in Aging and Alzheimer’s Disease: Focus on Mitophagy

The Neuroscientist, Год журнала: 2023, Номер 30(4), С. 440 - 457

Опубликована: Янв. 3, 2023

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid β and phosphorylated τ protein aggregates in brain, which leads to loss neurons. Under microscope, function mitochondria uniquely primed play a pivotal role neuronal cell survival, energy metabolism, death. Research studies indicate that mitochondrial dysfunction, excessive oxidative damage, defective mitophagy neurons are early indicators AD. This review article summarizes latest development AD: 1) mechanism pathways, 2) importance functions, 3) metabolic pathways 4) link between dysfunction mechanisms AD, 5) potential mitochondrial-targeted therapeutics interventions treat patients with

Язык: Английский

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Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain

Acta Neuropathologica Communications, Год журнала: 2023, Номер 11(1)

Опубликована: Март 31, 2023

Abstract Loss of synapses is the most robust pathological correlate Alzheimer’s disease (AD)-associated cognitive deficits, although underlying mechanism remains incompletely understood. Synaptic terminals have abundant mitochondria which play an indispensable role in synaptic function through ATP provision and calcium buffering. Mitochondrial dysfunction early prominent feature AD could contribute to deficits. Here, using electron microscopy, we examined with a focus on mitochondrial deficits presynaptic axonal dendritic spines cortical biopsy samples from clinically diagnosed age-matched non-AD control patients. vesicle density within axon was significantly decreased cases appeared largely due reserve pool, but there were more axons containing enlarged vesicles or dense core AD. Importantly, reduced number along increased damaged presynapse correlated changes SV density. Mitochondria post-synaptic also samples. This study provided evidence loss as suggested that both pre- compartments

Язык: Английский

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Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102119 - 102119

Опубликована: Ноя. 4, 2023

Язык: Английский

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CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction

Autophagy, Год журнала: 2023, Номер 20(3), С. 590 - 613

Опубликована: Ноя. 1, 2023

Although microglial activation is induced by an increase in chemokines, the role of mitophagy this process remains unclear. This study aimed to elucidate CKLF/CKLF1 (chemokine-like factor 1)-induced and neuroinflammation, as well underlying molecular mechanisms following CKLF treatment. determined that CKLF, inducible chemokine brain, leads markers, such DNM1L, PINK1 (PTEN putative kinase 1), PRKN, OPTN, along with a simultaneous autophagosome formation, evidenced elevated levels BECN1 MAP1LC3B (microtubule-associated protein 1 light chain 3 beta)-II. However, SQSTM1, substrate autophagy, was also accumulated treatment, suggesting flux reduced mitophagosomes accumulated. These findings were confirmed transmission electron microscopy confocal microscopy. The defective observed our caused impaired lysosomal function, including mitophagosome-lysosome fusion, lysosome generation, acidification, resulting accumulation damaged mitochondria cells. Further analysis revealed pharmacological blocking or gene-silencing inhibited CKLF-mediated activation, expression marker AIF1 (allograft inflammatory 1) mRNA proinflammatory cytokines (Tnf Il6). Ultimately, results brains adult mice. In summary, induces mitophagy, inflammation, providing potential approach for treating neuroinflammatory diseases.

Язык: Английский

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Exploring Advancements in Early Detection of Alzheimer's Disease with Molecular Assays and Animal Models

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102411 - 102411

Опубликована: Июль 9, 2024

Язык: Английский

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Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domains

Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2024, Номер 10(2)

Опубликована: Апрель 1, 2024

Abstract INTRODUCTION Alzheimer's disease (AD) is the predominant dementia globally, with heterogeneous presentation and penetrance of clinical symptoms, variable presence mixed pathologies, potential subtypes, numerous associated endophenotypes. Beyond difficulty designing treatments that address core pathological characteristics disease, therapeutic development challenged by uncertainty which endophenotypic areas specific targets implicated those endophenotypes to prioritize for further translational research. However, publicly funded consortia driving large‐scale open science efforts have produced multiple omic analyses both risk relevance biological process involvement genes across genome. METHODS Here we report an informatic pipeline draws from genetic association studies, predicted variant impact, linkage phenotypes create a score. This paired multi‐omic score utilizing extensive sets transcriptomic proteomic studies identify system‐level changes in expression AD. These two elements combined constitute our target ranks AD genome‐wide. The ranked are organized into space through 19 domains described genetics genomics accompanying literature. constructed exhaustive Gene Ontology (GO) term compilations, allowing automated assignment objectively defined disease‐associated biology. rank‐and‐organize approach, performed genome‐wide, allows characterization aggregations domains. RESULTS top AD‐risk‐associated Synapse, Immune Response, Lipid Metabolism, Mitochondrial Structural Stabilization, Proteostasis, slightly lower levels enrichment present within other 13 DISCUSSION provides objective methodology localize drill down most significantly GO terms annotated targets.

Язык: Английский

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Mitochondrial dynamics and mitochondrial autophagy: Molecular structure, orchestrating mechanism and related disorders

Mitochondrion, Год журнала: 2024, Номер 75, С. 101847 - 101847

Опубликована: Янв. 19, 2024

Mitochondrial dynamics and autophagy play essential roles in normal cellular physiological activities, while abnormal mitochondrial can cause cancer related disorders. Abnormal usually occur parallel with autophagy. Both have been reported to a synergistic effect therefore complement or inhibit each other. Progress has made understanding the classical PINK1/Parkin pathway dynamical abnormalities. Still, mechanisms regulatory pathways underlying interaction between mitophagy remain unexplored. Like other existing reviews, we review molecular structure of proteins involved autophagy, how their abnormalities lead development diseases. We will also individual effects leading proliferation, differentiation invasion. In addition, explore contribute targeted precise regulation function. Through study mechanisms, as well role early disease development, effective targets for function be proposed enable accurate diagnosis treatment associated

Язык: Английский

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