Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2023, Номер 266, С. 109551 - 109551
Опубликована: Янв. 18, 2023
Язык: Английский
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2023, Номер 266, С. 109551 - 109551
Опубликована: Янв. 18, 2023
Язык: Английский
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 8, 2025
Herbicide paraquat dichloride, a potent redox agent found its way to natural water bodies and influences their health; however, impact on the reproductive health of fish is potentially less studied requires clear investigation. This study was conducted elucidate effect gonadal female fish, Channa punctatus over 60 days. The 96-h LC50 test herbicide calculated as 0.24 mL/L for under examination, subsequently, three sub-lethal concentrations were taken in addition control study. experimental methodology included assessment oxidative stress markers, hormone levels, expression interrelated genes, histological analysis ascertain damage ovary. At each exposure period, significant (p < 0.05) rise endogenous reactive oxygen species blood cells activities markers ovary tissue observed treated groups. gonadosomatic index concentration plasma decreased at highest treatment concentration. A change target genes growth, inflammation, apoptosis fish. Histopathological ultrastructural investigations revealed occurrence oophoritis reduced growth herbicide-treated findings conclude that, dichloride causes inflammation ovary, reduction that ultimately, poses threat population.
Язык: Английский
Процитировано
1Fish & Shellfish Immunology, Год журнала: 2022, Номер 131, С. 1063 - 1074
Опубликована: Ноя. 11, 2022
Язык: Английский
Процитировано
33Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 100, С. 104136 - 104136
Опубликована: Апрель 29, 2023
Язык: Английский
Процитировано
20Environmental Toxicology, Год журнала: 2023, Номер 38(6), С. 1226 - 1238
Опубликована: Март 8, 2023
Abstract Di(2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor. Microplastics (MPs) are pathogenic small plastic particles abundant in the aqueous environment. The problem of residual hazards products worthy study, especially joint exposure variety plastic‐related to toxic effect. We used 200 mg/kg DEHP 10 mg/L MPs establish model vivo 2 mM μg/L AML12 cell vitro. In study results showed that compared with control group (NC) group, significantly increased contents malondialdehyde hydrogen peroxide, decreased glutathione activity superoxide dismutase, total antioxidant capacity, catalase peroxidase. level oxidative stress was further aggravated after combined exposure. reactive oxygen species exposed vitro higher than NC single also confirmed could increase mRNA protein levels apoptosis markers necroptosis there additive After N‐acetylcysteine treatment vitro, above‐mentioned damage significantly. This provided reference for advocating reduction mixed use products, basis preventing harm residues.
Язык: Английский
Процитировано
19Journal of Environmental Management, Год журнала: 2024, Номер 371, С. 123235 - 123235
Опубликована: Ноя. 6, 2024
Язык: Английский
Процитировано
7Ecotoxicology and Environmental Safety, Год журнала: 2022, Номер 248, С. 114327 - 114327
Опубликована: Ноя. 24, 2022
Trimethyltin (TMT) is widely used as a major component of plastic stabilizers in agriculture and industry, can accumulate large quantities the liver. To investigate relationship between liver tissue damage induced by TMT exposure YAP phosphorylation mice, we gave mice drinking water containing 0.01 mg/mL for 14 days to establish an vivo experimental model, continuously treated AML12 cells with 20 μM 24 h vitro model. Transcriptomics revealed that altered 62,466 apparently diversely expressed genes, including 1197 upregulated 899 downregulated enrichment Hippo pathway occurred. Moreover, western blotting (WB) quantitative real-time PCR (qRTPCR) results showed triggered increase expression P-YAP, apoptosis necroptosis-interrelated decrease Bcl-2 mouse livers tissues cells. The P-YAP was significantly suppressed TRULI-treated TMT-exposed cells, while oxidative stress levels were also attenuated. In conclusion, triggers induce inducing necroptosis tissues. Our confirm toxic effect specific mechanism TMT.
Язык: Английский
Процитировано
27Fish & Shellfish Immunology, Год журнала: 2022, Номер 130, С. 490 - 500
Опубликована: Сен. 24, 2022
Язык: Английский
Процитировано
23Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 193, С. 105445 - 105445
Опубликована: Май 15, 2023
Язык: Английский
Процитировано
16Fish & Shellfish Immunology, Год журнала: 2023, Номер 135, С. 108687 - 108687
Опубликована: Март 13, 2023
Язык: Английский
Процитировано
14The Science of The Total Environment, Год журнала: 2022, Номер 863, С. 160601 - 160601
Опубликована: Дек. 15, 2022
Язык: Английский
Процитировано
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