Environmental Toxicology,
Год журнала:
2023,
Номер
38(6), С. 1226 - 1238
Опубликована: Март 8, 2023
Abstract
Di(2‐ethylhexyl)
phthalate
(DEHP)
is
a
plasticizer
and
an
endocrine
disruptor.
Microplastics
(MPs)
are
pathogenic
small
plastic
particles
abundant
in
the
aqueous
environment.
The
problem
of
residual
hazards
products
worthy
study,
especially
joint
exposure
variety
plastic‐related
to
toxic
effect.
We
used
200
mg/kg
DEHP
10
mg/L
MPs
establish
model
vivo
2
mM
μg/L
AML12
cell
vitro.
In
study
results
showed
that
compared
with
control
group
(NC)
group,
significantly
increased
contents
malondialdehyde
hydrogen
peroxide,
decreased
glutathione
activity
superoxide
dismutase,
total
antioxidant
capacity,
catalase
peroxidase.
level
oxidative
stress
was
further
aggravated
after
combined
exposure.
reactive
oxygen
species
exposed
vitro
higher
than
NC
single
also
confirmed
could
increase
mRNA
protein
levels
apoptosis
markers
necroptosis
there
additive
After
N‐acetylcysteine
treatment
vitro,
above‐mentioned
damage
significantly.
This
provided
reference
for
advocating
reduction
mixed
use
products,
basis
preventing
harm
residues.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 8, 2025
Herbicide
paraquat
dichloride,
a
potent
redox
agent
found
its
way
to
natural
water
bodies
and
influences
their
health;
however,
impact
on
the
reproductive
health
of
fish
is
potentially
less
studied
requires
clear
investigation.
This
study
was
conducted
elucidate
effect
gonadal
female
fish,
Channa
punctatus
over
60
days.
The
96-h
LC50
test
herbicide
calculated
as
0.24
mL/L
for
under
examination,
subsequently,
three
sub-lethal
concentrations
were
taken
in
addition
control
study.
experimental
methodology
included
assessment
oxidative
stress
markers,
hormone
levels,
expression
interrelated
genes,
histological
analysis
ascertain
damage
ovary.
At
each
exposure
period,
significant
(p
<
0.05)
rise
endogenous
reactive
oxygen
species
blood
cells
activities
markers
ovary
tissue
observed
treated
groups.
gonadosomatic
index
concentration
plasma
decreased
at
highest
treatment
concentration.
A
change
target
genes
growth,
inflammation,
apoptosis
fish.
Histopathological
ultrastructural
investigations
revealed
occurrence
oophoritis
reduced
growth
herbicide-treated
findings
conclude
that,
dichloride
causes
inflammation
ovary,
reduction
that
ultimately,
poses
threat
population.
Ecotoxicology and Environmental Safety,
Год журнала:
2022,
Номер
248, С. 114327 - 114327
Опубликована: Ноя. 24, 2022
Trimethyltin
(TMT)
is
widely
used
as
a
major
component
of
plastic
stabilizers
in
agriculture
and
industry,
can
accumulate
large
quantities
the
liver.
To
investigate
relationship
between
liver
tissue
damage
induced
by
TMT
exposure
YAP
phosphorylation
mice,
we
gave
mice
drinking
water
containing
0.01
mg/mL
for
14
days
to
establish
an
vivo
experimental
model,
continuously
treated
AML12
cells
with
20
μM
24
h
vitro
model.
Transcriptomics
revealed
that
altered
62,466
apparently
diversely
expressed
genes,
including
1197
upregulated
899
downregulated
enrichment
Hippo
pathway
occurred.
Moreover,
western
blotting
(WB)
quantitative
real-time
PCR
(qRTPCR)
results
showed
triggered
increase
expression
P-YAP,
apoptosis
necroptosis-interrelated
decrease
Bcl-2
mouse
livers
tissues
cells.
The
P-YAP
was
significantly
suppressed
TRULI-treated
TMT-exposed
cells,
while
oxidative
stress
levels
were
also
attenuated.
In
conclusion,
triggers
induce
inducing
necroptosis
tissues.
Our
confirm
toxic
effect
specific
mechanism
TMT.
