Tannin alleviates glyphosate exposure-induced apoptosis, necrosis and immune dysfunction in hepatic L8824 cell line by inhibiting ROS/PTEN/PI3K/AKT pathway DOI
Linlin Zhang, Lu Chen, Dayong Tao

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2023, Номер 266, С. 109551 - 109551

Опубликована: Янв. 18, 2023

Язык: Английский

Oxidative toxicity mediated oophoritis alters ovarian growth in Channa punctatus under prolonged exposure to herbicide, paraquat dichloride DOI Creative Commons
Anamika Jain,

Shefalee Singh,

Seema Yadav

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 8, 2025

Herbicide paraquat dichloride, a potent redox agent found its way to natural water bodies and influences their health; however, impact on the reproductive health of fish is potentially less studied requires clear investigation. This study was conducted elucidate effect gonadal female fish, Channa punctatus over 60 days. The 96-h LC50 test herbicide calculated as 0.24 mL/L for under examination, subsequently, three sub-lethal concentrations were taken in addition control study. experimental methodology included assessment oxidative stress markers, hormone levels, expression interrelated genes, histological analysis ascertain damage ovary. At each exposure period, significant (p < 0.05) rise endogenous reactive oxygen species blood cells activities markers ovary tissue observed treated groups. gonadosomatic index concentration plasma decreased at highest treatment concentration. A change target genes growth, inflammation, apoptosis fish. Histopathological ultrastructural investigations revealed occurrence oophoritis reduced growth herbicide-treated findings conclude that, dichloride causes inflammation ovary, reduction that ultimately, poses threat population.

Язык: Английский

Процитировано

1

Melatonin ameliorates imidacloprid-induced intestinal injury by negatively regulating the PGN/P38MAPK pathway in the common carp (Cyprinus carpio) DOI

Zhiruo Miao,

Zhiying Miao,

Min Liu

и другие.

Fish & Shellfish Immunology, Год журнала: 2022, Номер 131, С. 1063 - 1074

Опубликована: Ноя. 11, 2022

Язык: Английский

Процитировано

33

Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis DOI
Junbo Li,

Kai Yin,

Lulu Hou

и другие.

Environmental Toxicology and Pharmacology, Год журнала: 2023, Номер 100, С. 104136 - 104136

Опубликована: Апрель 29, 2023

Язык: Английский

Процитировано

20

Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress DOI
Lu Chen,

Meng Qi,

Linlin Zhang

и другие.

Environmental Toxicology, Год журнала: 2023, Номер 38(6), С. 1226 - 1238

Опубликована: Март 8, 2023

Abstract Di(2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor. Microplastics (MPs) are pathogenic small plastic particles abundant in the aqueous environment. The problem of residual hazards products worthy study, especially joint exposure variety plastic‐related to toxic effect. We used 200 mg/kg DEHP 10 mg/L MPs establish model vivo 2 mM μg/L AML12 cell vitro. In study results showed that compared with control group (NC) group, significantly increased contents malondialdehyde hydrogen peroxide, decreased glutathione activity superoxide dismutase, total antioxidant capacity, catalase peroxidase. level oxidative stress was further aggravated after combined exposure. reactive oxygen species exposed vitro higher than NC single also confirmed could increase mRNA protein levels apoptosis markers necroptosis there additive After N‐acetylcysteine treatment vitro, above‐mentioned damage significantly. This provided reference for advocating reduction mixed use products, basis preventing harm residues.

Язык: Английский

Процитировано

19

Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway DOI
Xiaodan Wang,

Meichen Gao,

Xianping Lu

и другие.

Journal of Environmental Management, Год журнала: 2024, Номер 371, С. 123235 - 123235

Опубликована: Ноя. 6, 2024

Язык: Английский

Процитировано

7

Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation DOI Creative Commons
Yuqi Wang, Xiaojing Liu, Hongyuan Jing

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2022, Номер 248, С. 114327 - 114327

Опубликована: Ноя. 24, 2022

Trimethyltin (TMT) is widely used as a major component of plastic stabilizers in agriculture and industry, can accumulate large quantities the liver. To investigate relationship between liver tissue damage induced by TMT exposure YAP phosphorylation mice, we gave mice drinking water containing 0.01 mg/mL for 14 days to establish an vivo experimental model, continuously treated AML12 cells with 20 μM 24 h vitro model. Transcriptomics revealed that altered 62,466 apparently diversely expressed genes, including 1197 upregulated 899 downregulated enrichment Hippo pathway occurred. Moreover, western blotting (WB) quantitative real-time PCR (qRTPCR) results showed triggered increase expression P-YAP, apoptosis necroptosis-interrelated decrease Bcl-2 mouse livers tissues cells. The P-YAP was significantly suppressed TRULI-treated TMT-exposed cells, while oxidative stress levels were also attenuated. In conclusion, triggers induce inducing necroptosis tissues. Our confirm toxic effect specific mechanism TMT.

Язык: Английский

Процитировано

27

Eucalyptol relieves the toxicity of diisobutyl phthalate in Ctenopharyngodon idellus kidney cells through Keap1/Nrf2/HO-1 pathway: Apoptosis-autophagy crosstalk and immunoregulation DOI

Huanyi Liu,

Wenying Sun, Huijun Zhu

и другие.

Fish & Shellfish Immunology, Год журнала: 2022, Номер 130, С. 490 - 500

Опубликована: Сен. 24, 2022

Язык: Английский

Процитировано

23

Protective effect of quercetin on avermectin induced splenic toxicity in carp: Resistance to inflammatory response and oxidative damage DOI

Enzhuang Pan,

Huizhen Chen,

Xinyu Wu

и другие.

Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 193, С. 105445 - 105445

Опубликована: Май 15, 2023

Язык: Английский

Процитировано

16

Induction of autophagy via the ROS-dependent AMPK/mTOR pathway protects deoxynivalenol exposure grass carp hepatocytes damage DOI
Xin Chen, Jun Ma, Hao Chen

и другие.

Fish & Shellfish Immunology, Год журнала: 2023, Номер 135, С. 108687 - 108687

Опубликована: Март 13, 2023

Язык: Английский

Процитировано

14

Selenium alleviates cadmium-induced oxidative stress, endoplasmic reticulum stress and programmed necrosis in chicken testes DOI
Min Wang, Yueyue Wang,

Size Wang

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 863, С. 160601 - 160601

Опубликована: Дек. 15, 2022

Язык: Английский

Процитировано

23