Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 17, 2023
Abstract
Liver
fibrosis
is
a
crucial
step
in
the
progression
of
various
chronic
liver
diseases
to
cirrhosis,
which
can
affect
prognosis
diseases.
The
NAD
+
dependent
deacetylase
sirtuins
family
member
SIRT2
regulate
inflammatory
corpuscular
pathway
pathological
processes,
but
its
related
mechanism
not
yet
clear.
This
study
established
models
wild-type
and
knockout
mice,
evaluated
their
effects
on
homeostasis
using
immunoblotting,
immunofluorescence,
histopathological
staining
methods.
results
indicate
that
deletion
gene
enhances
NLRP3
acetylation,
activates
inflammasome
pathway,
accelerates
oxidative
stress.
These
findings
suggest
may
be
potential
target
for
regulating
restoring
health.
Ecotoxicology and Environmental Safety,
Год журнала:
2022,
Номер
248, С. 114327 - 114327
Опубликована: Ноя. 24, 2022
Trimethyltin
(TMT)
is
widely
used
as
a
major
component
of
plastic
stabilizers
in
agriculture
and
industry,
can
accumulate
large
quantities
the
liver.
To
investigate
relationship
between
liver
tissue
damage
induced
by
TMT
exposure
YAP
phosphorylation
mice,
we
gave
mice
drinking
water
containing
0.01
mg/mL
for
14
days
to
establish
an
vivo
experimental
model,
continuously
treated
AML12
cells
with
20
μM
24
h
vitro
model.
Transcriptomics
revealed
that
altered
62,466
apparently
diversely
expressed
genes,
including
1197
upregulated
899
downregulated
enrichment
Hippo
pathway
occurred.
Moreover,
western
blotting
(WB)
quantitative
real-time
PCR
(qRTPCR)
results
showed
triggered
increase
expression
P-YAP,
apoptosis
necroptosis-interrelated
decrease
Bcl-2
mouse
livers
tissues
cells.
The
P-YAP
was
significantly
suppressed
TRULI-treated
TMT-exposed
cells,
while
oxidative
stress
levels
were
also
attenuated.
In
conclusion,
triggers
induce
inducing
necroptosis
tissues.
Our
confirm
toxic
effect
specific
mechanism
TMT.
Environmental Toxicology,
Год журнала:
2023,
Номер
38(4), С. 820 - 832
Опубликована: Янв. 11, 2023
Abstract
Tetrabromobisphenol
A
(TBBPA)
is
a
common
environmental
pollutant
which
has
multi‐organ
toxicity
to
mammals.
Eucalyptol
(EUC)
super
antioxidant
biological
activity.
However,
in
this
experimental
study,
we
probed
into
the
mechanism
of
toxic
TBBPA
exposure
on
Grass
carp
hepatocytes
(L8824
cells)
and
antagonistic
impact
EUC
TBBPA.
We
treated
L8824
cells
with
8
μg/ml
and/or
20
μM
for
24
h
test
research.
The
experiment
results
suggested
that
induced
elevated
levels
reactive
oxygen
species
(ROS),
led
oxidative
stress,
decreased
SOD
CAT
activities,
GSH
T‐AOC
contents,
exacerbated
MDA
accumulation,
activated
ASK1/JNK
signaling
pathway,
further
increased
contents
mitochondrial
dependent
apoptosis
pathway
related
indicators
(Cyt‐C,
Bax,
Caspase
9,
3),
while
Bcl‐2
expression
decreased.
In
addition,
TNF‐α,
IL‐6,
IL‐1β,
IL‐2,
IFN‐γ,
Hepcidin,
β‐defensin,
LEAP2.
stress
level,
signal
ratio
cellular
immune
function
exposed
alone
did
not
change
significantly.
Combined
significantly
reduced
proportion
restored
function.
Therefore,
these
suggest
can
effectively
antagonize
TBBPA‐induced
dysfunction
by
regulating
ROS/ASK1/JNK
pathway.
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 365 - 365
Опубликована: Фев. 4, 2024
Ageing
is
a
natural
process
characterized
by
time-dependent
decline
of
physiological
integrity
that
compromises
functionality
and
inevitably
leads
to
death.
This
also
quite
relevant
in
major
human
pathologies,
being
primary
risk
factor
neurodegenerative
diseases,
metabolic
disorders,
cardiovascular
diseases
musculoskeletal
disorders.
Bearing
this
mind,
it
not
surprising
research
aiming
at
improving
health
during
has
burst
the
last
decades.
Importantly,
hallmarks
ageing
phenotype
have
been
identified,
knowledge
for
future
studies
towards
identification
putative
pharmaceutical
targets,
enabling
development
preventive/therapeutic
strategies
improve
longevity.
In
context,
aromatic
plants
emerged
as
source
potential
bioactive
volatile
molecules,
mainly
monoterpenes,
with
many
referring
their
anti-ageing
potential.
Nevertheless,
an
integrated
review
on
current
lacking,
several
approaches
studying
isolated
or
overall
effect,
without
depicting
possible
mechanisms
action.
Herein,
we
aim
provide
updated
systematization
monoterpenes
recently
proposed
hallmarks,
highlight
main
action
already
well
chemical
entity–activity
relations.
By
gathering
categorizing
available
scattered
information,
identify
important
gaps
could
help
pave
way
field.
