Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(12), С. 4292 - 4292
Опубликована: Янв. 1, 2022
Pyrazoles
are
the
most
important
five-membered
N-heterocycles
as
they
present
in
many
natural
products
and
synthetic
drugs.Among
various
pyrazole
derivatives,
4-bromopyrazoles
have
attracted
great
attention
because
not
only
display
significant
biological
activities
physicochemical
properties
but
also
serve
valuable
synthons
organic
chemistry.In
this
manuscript,
an
efficient
eco-friendly
method
for
synthesis
of
through
threecomponent
reaction
hydrazine,
acetylacetone
2-bromomalonate
was
reported
proposal
mechanism
revealed.According
to
mechanism,
hydrazine
reacts
with
afford
firstly,
which
then
converts
4-bromopyrazole
bromination.This
could
be
well
applicable
bromination
other
heterocyclic
compounds.Given
high
oxidation
state
diethyl
2-bromomalonate,
peroxidation
can
avoided
electrolysis
process,
thus
excess
amount
brominating
agent
required.
Chemical Communications,
Год журнала:
2023,
Номер
59(94), С. 14029 - 14032
Опубликована: Янв. 1, 2023
With
both
ferrocene
and
air
as
the
redox
catalysts,
for
first
time,
low-cost
natural
ilmenite
(FeTiO3)
was
successfully
used
photocatalytic
bond
formations.
Under
assistance
of
a
traceless
H-bond,
HCHO
methylene
reagent,
variety
imidazo[1,5-a]quinoxalinones
were
semi-heterogeneously
photosynthesized
in
high
yields
with
good
functional
group
compatibility.
Green Chemistry,
Год журнала:
2023,
Номер
25(14), С. 5539 - 5542
Опубликована: Янв. 1, 2023
With
formaldehyde
as
an
atom-economical
carbonyl
synthon,
the
EtOH-catalyzed
electrochemical
multicomponent
synthesis
of
various
imidazolidine-fused
sulfamidates
under
organic
oxidant-free,
energy-saving
and
mild
conditions
was
developed.
Chemical Communications,
Год журнала:
2023,
Номер
59(36), С. 5343 - 5364
Опубликована: Янв. 1, 2023
The
activation
and
transformation
of
organic
chemical
bonds
is
a
fundamental
scientific
problem.
In
the
past
several
decades,
C-S
bond
cleavage
for
construction
C-C
C-heteroatom
has
received
tremendous
attention
in
chemistry.
Although
significant
progress
been
made
field
transition
metal
strategies,
variety
novel
transition-metal-free
strategies
have
also
developed
using
halogenated
reagents,
oxidants,
acids,
bases.
Moreover,
photochemical
electrochemical
methods
to
achieve
organosulfur
compounds.
To
date,
however,
no
comprehensive
review
reported.
Therefore,
we
herein
provide
major
advances
compounds,
including
thioethers,
sulfoxides,
sulfones,
thioacetals,
sulfonium
salts,
sulfur
ylides.
Green Synthesis and Catalysis,
Год журнала:
2022,
Номер
4(1), С. 41 - 45
Опубликована: Март 4, 2022
The
simultaneous
binding/dissociation
of
multiple
bonds
in
a
one-pot
manner
by
multicomponent
reactions
provide
an
important
approach
for
developing
novel
and
sustainable
pathway
the
drug
discovery
process.
Herein
we
develop
electrocatalytic
three-component
reaction
to
construct
multifunctional
valuable
isothiourea
compounds,
which
uses
thiols,
isocyanides
amines
as
substrates.
Compared
with
previous
work,
organic
electrosynthesis
technique
can
avoid
requirement
heavy
metal
catalysts
stoichiometric
oxidants.
In
addition,
using
thiol
substrate
participate
broadens
source
sulfur,
also
more
abundant
derivatives.
