Natural Product Reports, Год журнала: 2023, Номер 41(1), С. 59 - 84
Опубликована: Окт. 11, 2023
Covering: up to 2023Huperzine alkaloids are a group of natural products belonging the
Язык: Английский
Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(23), С. 4024 - 4048
Опубликована: Май 17, 2023
Abstract Since their structural elucidation in 1935, the introduction and substitution of functional groups modification steroidal scaffolds have been a fertile ground research for synthetic medicinal chemists. The discovery steroids with hormonal pharmacological activity has stimulated tremendous efforts to development highly selective efficient procedures. Despite progress made, steroid chemistry remains challenging preparation compounds pharmaceutical interests clinical practice, often requires long elaborated synthesis. In recent years, new impetus field came advent enabling chemical technologies, such as continuous flow chemistry, which are exploited overcome problems that arise from batch Although it is still niche sector, use technology synthesis functionalization holds premise empower methodology provide innovative tactics also many hitherto uncharted chemistries. this review, scientific contributions reported discussed terms set‐up advantages offered concerning process efficiency, optimization, waste minimization, safety improvement, easy scale‐up costs. We highlight main challenges, key improvements future trajectory application its implementation different disciplines photochemistry biocatalysis ultimate goal streamlining
Язык: Английский
Процитировано
9
Green Synthesis and Catalysis, Год журнала: 2023, Номер 4(2), С. 154 - 159
Опубликована: Янв. 16, 2023
Metal contamination is a waste-generating and serious issue in the synthesis of chemicals, particular case products with biological activity. The appropriate selection operating conditions plays crucial role abatement metal leaching solution associated wastes. Herein we report waste-minimized continuous flow process for 1,4-disubstituted β-keto 1,2,3-triazoles exploiting use copper tube reactor (CTFR). proper azeotropic mixture allowed an almost quantitative recovery reaction medium greatly influencing E-factor protocol. A thorough understanding main parameters affecting waste generation was given by calculation distribution different work-up tested under batch conditions. Furthermore, measurement green metrics (AE: Atom Economy, SF: Stoichiometric Factor, RME: Reaction Mass Efficiency, MRP: Recover Parameter) clearly demonstrated benefits scale-up that to perform low environmental footprint CuAAC reaction.
Язык: Английский
Процитировано
8
Green Chemistry, Год журнала: 2023, Номер 25(6), С. 2438 - 2445
Опубликована: Янв. 1, 2023
We herein report a multi-step flow protocol for the synthesis of 1,4-disubstituted 1,2,3-triazoles starting from α,β-unsaturated carbonyls.
Язык: Английский
Процитировано
8
Bioresource Technology, Год журнала: 2024, Номер 403, С. 130888 - 130888
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
2
AIChE Journal, Год журнала: 2024, Номер 70(10)
Опубликована: Июнь 21, 2024
Abstract The scale‐up of microreactor‐based flow chemical process represents a grand challenge in engineering. small characteristic size (<1000 μm) typical microreactor leads to not only microscale effect (process intensification) but also low throughput. Here, we report macro‐microreactor achieve liquid–liquid operation with intensification. By incorporating the designed internals based on computational fluid dynamics, is expanded into 3000–4000 μm. optimized design helical‐shaped internal exhibits both similar or even stronger and high throughput contrast microreactor. For process, seven times higher mass transfer coefficient about half reduction pressure drop are realized. These macro‐microreactors would find further applications industrial manufacturing.
Язык: Английский
Процитировано
2
Chemical Engineering Science, Год журнала: 2024, Номер 299, С. 120430 - 120430
Опубликована: Июнь 30, 2024
Язык: Английский
Процитировано
2
Sustainable Chemistry and Pharmacy, Год журнала: 2024, Номер 41, С. 101725 - 101725
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
2
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The regioselective 1,2-dicarbonylation of aryls and heteroaryls offers access to functionalized dicarbonylated heteroaryls, which opens pharmaceuticals bioactive molecules with diverse synthetic utility.
Язык: Английский
Процитировано
2
Chinese Chemical Letters, Год журнала: 2023, Номер 35(2), С. 108576 - 108576
Опубликована: Май 20, 2023
Язык: Английский
Процитировано
6
Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(4)
Опубликована: Ноя. 23, 2023
16β-Methylcorticoids are among the most important glucocorticoid steroids for treatment of various dermatological disorders, respiratory infections, and other allergic reactions elicited during inflammatory responses human body. Betamethasone dipropionate, clobetasol propionate, beclomethasone dipropionate particularly noteworthy their synthetic intractability. Despite five decades research, these 16β-methylcorticoids have remained challenging targets owing to insurmountable issues reactivity, selectivity, cost efficiency associated with all previously explored strategies. We herein report our practicability-oriented strategy toward unified stereoselective synthesis in 12.6-14.0 % overall yield from commercially available 9α-hydroxyandrost-4-ene-3,17-dione (9α-OH-AD). In this approach, chiral C16β-Me C17α-OH groups corticosteroid D ring were installed via a substrate-controlled diastereo- enantioselective Mn-catalyzed oxidation-reduction hydration Δ
Язык: Английский
Процитировано
6