Huperzine alkaloids: forty years of total syntheses DOI
Bichu Cheng, Lili Song, Fen‐Er Chen

et al.

Natural Product Reports, Journal Year: 2023, Volume and Issue: 41(1), P. 59 - 84

Published: Oct. 11, 2023

Covering: up to 2023Huperzine alkaloids are a group of natural products belonging the

Language: Английский

Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis DOI Creative Commons

Elena Tomarelli,

Bruno Cerra, Francesco G. Mutti

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(23), P. 4024 - 4048

Published: May 17, 2023

Abstract Since their structural elucidation in 1935, the introduction and substitution of functional groups modification steroidal scaffolds have been a fertile ground research for synthetic medicinal chemists. The discovery steroids with hormonal pharmacological activity has stimulated tremendous efforts to development highly selective efficient procedures. Despite progress made, steroid chemistry remains challenging preparation compounds pharmaceutical interests clinical practice, often requires long elaborated synthesis. In recent years, new impetus field came advent enabling chemical technologies, such as continuous flow chemistry, which are exploited overcome problems that arise from batch Although it is still niche sector, use technology synthesis functionalization holds premise empower methodology provide innovative tactics also many hitherto uncharted chemistries. this review, scientific contributions reported discussed terms set‐up advantages offered concerning process efficiency, optimization, waste minimization, safety improvement, easy scale‐up costs. We highlight main challenges, key improvements future trajectory application its implementation different disciplines photochemistry biocatalysis ultimate goal streamlining

Language: Английский

Citations

9
Waste-minimized continuous flow copper-catalyzed azide-alkyne cycloaddition with low metal contamination DOI Creative Commons

Giulia Brufani,

Federica Valentini,

Gabriele Rossini

et al.

Green Synthesis and Catalysis, Journal Year: 2023, Volume and Issue: 4(2), P. 154 - 159

Published: Jan. 16, 2023

Metal contamination is a waste-generating and serious issue in the synthesis of chemicals, particular case products with biological activity. The appropriate selection operating conditions plays crucial role abatement metal leaching solution associated wastes. Herein we report waste-minimized continuous flow process for 1,4-disubstituted β-keto 1,2,3-triazoles exploiting use copper tube reactor (CTFR). proper azeotropic mixture allowed an almost quantitative recovery reaction medium greatly influencing E-factor protocol. A thorough understanding main parameters affecting waste generation was given by calculation distribution different work-up tested under batch conditions. Furthermore, measurement green metrics (AE: Atom Economy, SF: Stoichiometric Factor, RME: Reaction Mass Efficiency, MRP: Recover Parameter) clearly demonstrated benefits scale-up that to perform low environmental footprint CuAAC reaction.

Language: Английский

Citations

8
Continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles via consecutive β-azidation of α,β-unsaturated carbonyl compounds and CuAAC reactions DOI Creative Commons

Giulia Brufani,

Federica Valentini,

Gabriele Rossini

et al.

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(6), P. 2438 - 2445

Published: Jan. 1, 2023

We herein report a multi-step flow protocol for the synthesis of 1,4-disubstituted 1,2,3-triazoles starting from α,β-unsaturated carbonyls.

Language: Английский

Citations

8
Continuous and autonomous-flow separation of laccase enzyme utilizing functionalized aqueous two-phase system with computer vision control DOI
Vikas Sharma, Jeong‐Un Joo,

Amirreza Mottafegh

et al.

Bioresource Technology, Journal Year: 2024, Volume and Issue: 403, P. 130888 - 130888

Published: May 22, 2024

Language: Английский

Citations

2
Optimized design of macro‐microreactor for scale‐up of liquid–liquid chemical processes DOI
Shuangfei Zhao, Xin Hu,

Huiyue Wang

et al.

AIChE Journal, Journal Year: 2024, Volume and Issue: 70(10)

Published: June 21, 2024

Abstract The scale‐up of microreactor‐based flow chemical process represents a grand challenge in engineering. small characteristic size (<1000 μm) typical microreactor leads to not only microscale effect (process intensification) but also low throughput. Here, we report macro‐microreactor achieve liquid–liquid operation with intensification. By incorporating the designed internals based on computational fluid dynamics, is expanded into 3000–4000 μm. optimized design helical‐shaped internal exhibits both similar or even stronger and high throughput contrast microreactor. For process, seven times higher mass transfer coefficient about half reduction pressure drop are realized. These macro‐microreactors would find further applications industrial manufacturing.

Language: Английский

Citations

2
Mechanism study and formula development by numerical simulation and visualization experiment in a microfluidic system for enhanced oil recovery DOI
Haoyu Zhang,

H. D. Ye,

Hanfei Liu

et al.

Chemical Engineering Science, Journal Year: 2024, Volume and Issue: 299, P. 120430 - 120430

Published: June 30, 2024

Language: Английский

Citations

2
The chronological evolution of environment benign processes in the synthesis of natural products and APIs DOI
Geetmani Singh Nongthombam,

Abhipsha Saikia,

Jagat C. Borah

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 41, P. 101725 - 101725

Published: Aug. 14, 2024

Language: Английский

Citations

2
Synthetic Routes to Access Dicarbonylated Aryls and Heteroaryls DOI
Swadhin Swaraj Acharya, Bibhuti Bhusan Parida

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The regioselective 1,2-dicarbonylation of aryls and heteroaryls offers access to functionalized dicarbonylated heteroaryls, which opens pharmaceuticals bioactive molecules with diverse synthetic utility.

Language: Английский

Citations

2
Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions: Rapid, scalable and sustainable approach to 2-arylpropionic acids DOI
Li Qiao,

Minjie Liu,

Meifen Jiang

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(2), P. 108576 - 108576

Published: May 20, 2023

Language: Английский

Citations

6
Divergent Chemo‐ and Biocatalytic Route to 16β‐Methylcorticoids: Asymmetric Synthesis of Betamethasone Dipropionate, Clobetasol Propionate, and Beclomethasone Dipropionate DOI Open Access

Jianhai Wei,

Yajiao Zhang,

Minjie Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(4)

Published: Nov. 23, 2023

16β-Methylcorticoids are among the most important glucocorticoid steroids for treatment of various dermatological disorders, respiratory infections, and other allergic reactions elicited during inflammatory responses human body. Betamethasone dipropionate, clobetasol propionate, beclomethasone dipropionate particularly noteworthy their synthetic intractability. Despite five decades research, these 16β-methylcorticoids have remained challenging targets owing to insurmountable issues reactivity, selectivity, cost efficiency associated with all previously explored strategies. We herein report our practicability-oriented strategy toward unified stereoselective synthesis in 12.6-14.0 % overall yield from commercially available 9α-hydroxyandrost-4-ene-3,17-dione (9α-OH-AD). In this approach, chiral C16β-Me C17α-OH groups corticosteroid D ring were installed via a substrate-controlled diastereo- enantioselective Mn-catalyzed oxidation-reduction hydration Δ

Language: Английский

Citations

6