International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2213 - 2213
Опубликована: Янв. 22, 2023
Hypertension
is
a
major
health
concern
globally.
Elevated
blood
pressure,
initiated
and
maintained
by
the
brain,
defined
as
neurogenic
hypertension
(NH),
which
accounts
for
nearly
half
of
all
cases.
A
significant
increase
in
angiotensin
II-mediated
sympathetic
nervous
system
activity
within
brain
known
to
be
key
driving
force
behind
NH.
Blood
pressure
control
NH
has
been
demonstrated
through
intracerebrovascular
injection
agents
that
reduce
influence
on
cardiac
functions.
However,
traditional
antihypertensive
lack
effective
permeation,
making
management
extremely
challenging.
Therefore,
developing
strategies
allow
brain-targeted
delivery
antihypertensives
at
therapeutic
level
crucial.
Targeting
nanotherapeutics
have
become
popular
delivering
therapeutics
hard-to-reach
regions
body,
including
brain.
Despite
frequent
use
other
pathological
conditions
such
cancer,
their
received
very
little
attention.
This
review
discusses
underlying
pathophysiology
current
NH,
well
potential
role
targeted
improving
treatment
strategies.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 23, 2023
Cancer
causes
significant
mortality
and
morbidity
worldwide,
but
existing
pharmacological
treatments
are
greatly
limited
by
the
inherent
heterogeneity
of
cancer
as
a
disease,
well
unsatisfactory
efficacy
specificity
therapeutic
drugs.
Biopharmaceutical
barriers
such
low
permeability
poor
water
solubility,
along
with
absence
active
targeting
capabilities,
often
result
in
suboptimal
clinical
results.
The
difficulty
successfully
reaching
destroying
tumor
cells
is
also
compounded
undesirable
impacts
on
healthy
tissue,
including
off-target
effects
high
toxicity,
which
further
impair
ability
to
effectively
manage
disease
optimize
patient
outcomes.
However,
last
few
decades,
development
nanotherapeutics
has
allowed
for
use
rational
design
order
maximize
success.
Advances
fabrication
nano-sized
delivery
systems,
coupled
variety
surface
engineering
strategies
promote
customization,
have
resulted
promising
approaches
targeted,
site-specific
drug
fewer
unwanted
better
efficacy.
These
nano
systems
been
able
overcome
some
challenges
conventional
related
pharmacokinetics,
biodistribution,
target
specificity.
In
particular,
lipid-based
nanosystems
extensively
explored
due
their
biocompatibility,
versatility,
adaptability.
Lipid-based
treatment
varied
diverse,
liposomal
therapeutics,
lipidic
nanoemulsions,
solid
lipid
nanoparticles,
nanostructured
carriers,
lipid-polymer
nanohybrids,
supramolecular
nanolipidic
structures.
This
review
aims
provide
an
overview
diverse
formulations
lipid-engineered
current
field,
researchers
attempt
translate
these
from
bench
clinic.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Апрель 17, 2024
Abstract
Autophagy,
a
catabolic
process
integral
to
cellular
homeostasis,
is
constitutively
active
under
physiological
and
stress
conditions.
The
role
of
autophagy
as
defense
response
becomes
particularly
evident
upon
exposure
nanomaterials
(NMs),
especially
environmental
nanoparticles
(NPs)
nanoplastics
(nPs).
This
has
positioned
modulation
at
the
forefront
nanotechnology-based
therapeutic
interventions.
While
NMs
can
exploit
enhance
outcomes,
they
also
trigger
it
pro-survival
against
NP-induced
toxicity.
Conversely,
heightened
may
lead
regulated
cell
death
(RCD),
in
particular
autophagic
death,
NP
exposure.
Thus,
relationship
between
exhibits
dual
nature
with
Recognizing
decoding
these
intricate
patterns
are
essential
for
pioneering
next-generation
autophagy-regulating
NMs.
review
delves
into
present-day
potential
autophagy-modulating
NMs,
shedding
light
on
their
status
clinical
trials,
intervention
applications
discusses
potency
application
early
indicator
NM
Graphical
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(7)
Опубликована: Окт. 31, 2023
Abstract
Nanosponges
are
unique
sponge‐like
carrier
systems
with
numerous
cavities
and
a
mesh‐like
network
throughout
their
surface.
They
categorized
into
three
types
based
on
the
material
of
construction,
i.e.,
polymer‐,
inorganic‐,
bio‐derived
material‐based
nanosponges.
Unlike
conventional
nanoparticles,
nanosponges
bear
countless
interconnected
voids
that
enables
maximum
drug,
imaging
probe,
or
photosensitizer
loading
via
absorption,
encapsulation,
conjugation,
complexion.
The
can
be
further
sealed
using
suitable
lipids
polymers
to
avoid
leakage
drugs
at
non‐target
site,
protect
therapeutics
from
biological
conditions,
control
release
for
prolonged
period.
Recently,
have
grasped
attention
researchers
in
area
cancer
by
overcoming
drawbacks
associated
delivery
immunotherapeutic,
targeted
therapeutic,
chemotherapeutic
agents.
Interestingly,
several
reports
also
witnessed
potential
theranostics.
Owing
this
supremacy,
could
an
apt
platform
therapy
diagnosis.
current
review
discusses
general
aspects,
types,
preparation
methods
In
addition,
ambit
treating
different
is
meticulously
discussed,
along
detailed
descriptions
corresponding
patents.
Furthermore,
role
phototherapy
theranostics
selectively
canvassed.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 751 - 751
Опубликована: Фев. 23, 2023
Cancer
is
one
of
the
major
public
health
problems
worldwide.
Despite
advances
in
cancer
therapy,
it
remains
a
challenge
due
to
low
specificity
treatment
and
development
multidrug
resistance
mechanisms.
To
overcome
these
drawbacks,
several
drug
delivery
nanosystems
have
been
investigated,
among
them,
magnetic
nanoparticles
(MNP),
especially
superparamagnetic
iron
oxide
(SPION),
which
applied
for
treating
cancer.
MNPs
ability
be
guided
tumor
microenvironment
through
an
external
field.
Furthermore,
presence
alternating
field
(AMF)
this
nanocarrier
can
transform
electromagnetic
energy
heat
(above
42
°C)
Néel
Brown
relaxation,
makes
applicable
hyperthermia
treatment.
However,
chemical
physical
stability
their
coating
necessary.
Thus,
lipid-based
nanoparticles,
liposomes,
used
encapsulate
improve
enable
use
as
This
review
addresses
main
features
that
make
most
recent
research
nanomedicine
using
hybrid
purpose.
Cancers,
Год журнала:
2023,
Номер
15(9), С. 2661 - 2661
Опубликована: Май 8, 2023
Breast
cancer
is
a
heterogeneous
disease
which
accounts
globally
for
approximately
1
million
new
cases
annually,
wherein
more
than
200,000
of
these
turn
out
to
be
triple-negative
breast
(TNBC).
TNBC
an
aggressive
and
rare
subtype
that
10–15%
all
cases.
Chemotherapy
remains
the
only
therapy
regimen
against
TNBC.
However,
emergence
innate
or
acquired
chemoresistance
has
hindered
chemotherapy
used
treat
The
data
obtained
from
molecular
technologies
have
recognized
with
various
gene
profiling
mutation
settings
helped
establish
develop
targeted
therapies.
New
therapeutic
strategies
based
on
delivery
therapeutics
relied
application
biomarkers
derived
patients.
Several
been
found
are
targets
precision
in
TNBC,
such
as
EGFR,
VGFR,
TP53,
interleukins,
insulin-like
growth
factor
binding
proteins,
c-MET,
androgen
receptor,
BRCA1,
glucocorticoid,
PTEN,
ALDH1,
etc.
This
review
discusses
candidate
identified
treatment
along
evidence
supporting
their
use.
It
was
established
nanoparticles
had
considered
multifunctional
system
delivering
target
sites
increased
precision.
Here,
we
also
discuss
role
nanotechnology
translation
management.
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 55 - 86
Опубликована: Март 7, 2025
Gene
drug
delivery
is
a
pivotal
approach
in
modern
cancer
treatment,
offering
targeted
therapies
that
overcome
the
limitations
of
conventional
methods.
This
chapter
delves
into
significance
gene
therapy
oncology,
highlighting
key
mechanisms
like
silencing,
suicide
genes,
and
tumor
suppressor
replacement
to
inhibit
progression.
Advanced
systems
are
essential
for
effective
therapy.
The
explores
nanocarriers
both
viral
nonviral
methods
as
critical
tools
improving
precision.
editing
technologies
CRISPR-Cas9
also
investigated
their
potential
transform
treatment.
integration
with
other
modalities,
such
immunotherapy
personalized
medicine,
proposed
way
improve
patient
outcomes.
Future
directions
developing
trends
therapy,
including
innovations
persistent
obstacles
clinical
translation,
explored.
offers
concise
overview
current
future
prospects
