Biosensors,
Год журнала:
2025,
Номер
15(4), С. 222 - 222
Опубликована: Март 31, 2025
The
growing
demand
for
real-time,
non-invasive,
and
cost-effective
health
monitoring
has
driven
significant
advancements
in
portable
point-of-care
testing
(POCT)
devices.
Among
these,
optical
biosensors
have
emerged
as
promising
tools
the
detection
of
critical
biomarkers
such
uric
acid
(UA)
blood
glucose.
Different
transduction
methods,
like
fluorescence,
surface
plasmon
resonance
(SPR),
colorimetric
approaches,
are
talked
about,
with
a
focus
on
how
sensitive,
specific,
they
are.
Despite
considerable
advancements,
several
challenges
persist,
including
sensor
stability,
miniaturization,
interference
effects,
need
calibration-free
operation.
This
review
also
explores
issues
related
to
cost-effectiveness,
data
integration,
wireless
connectivity
remote
monitoring.
further
examines
regulatory
considerations
commercialization
aspects
biosensors,
addressing
gap
between
research
developments
clinical
implementation.
Future
perspectives
emphasize
integration
artificial
intelligence
(AI)
healthcare
improved
diagnostics,
alongside
development
wearable
implantable
continuous
Innovative
potential
change
way
people
manage
their
by
quickly
accurately
measuring
glucose
levels.
is
especially
true
decentralized
solutions
grows.
By
critically
evaluating
existing
work
exploring
limitations
opportunities
field,
this
will
help
guide
more
efficient,
accessible,
reliable
POCT
devices
that
can
improve
patient
outcomes
quality
life.
Applied Biosciences,
Год журнала:
2024,
Номер
3(1), С. 14 - 44
Опубликована: Янв. 1, 2024
The
purpose
of
this
literature
review
is
to
provide
a
fundamental
synopsis
current
research
pertaining
artificial
intelligence
(AI)
within
the
domain
clinical
practice.
Artificial
has
revolutionized
field
medicine
and
healthcare
by
providing
innovative
solutions
complex
problems.
One
most
important
benefits
AI
in
practice
its
ability
investigate
extensive
volumes
data
with
efficiency
precision.
This
led
development
various
applications
that
have
improved
patient
outcomes
reduced
workload
professionals.
can
support
doctors
making
more
accurate
diagnoses
developing
personalized
treatment
plans.
Successful
examples
are
outlined
for
series
medical
specialties
like
cardiology,
surgery,
gastroenterology,
pneumology,
nephrology,
urology,
dermatology,
orthopedics,
neurology,
gynecology,
ophthalmology,
pediatrics,
hematology,
critically
ill
patients,
as
well
diagnostic
methods.
Special
reference
made
legal
ethical
considerations
accuracy,
informed
consent,
privacy
issues,
security,
regulatory
framework,
product
liability,
explainability,
transparency.
Finally,
closes
appraising
use
future
perspectives.
However,
it
also
approach
implementation
cautiously
ensure
met.
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Авг. 23, 2024
The
present
umbrella
review
aims
to
collate
and
summarize
the
findings
from
previous
meta-analyses
on
Triglyceride
Glucose
(TyG)
Index,
providing
insights
clinicians,
researchers,
policymakers
regarding
usefulness
of
this
biomarker
in
various
clinical
settings.
A
comprehensive
search
was
conducted
PubMed,
Scopus,
Web
Science
up
April
14,
2024,
without
language
restrictions.
AMSTAR2
checklist
assessed
methodological
quality
included
meta-analyses.
Statistical
analyses
were
performed
using
Comprehensive
Meta-Analysis
(CMA)
software.
total
32
studies
finally
included.
results
revealed
significant
associations
between
TyG
index
health
outcomes.
For
kidney
outcomes,
a
high
significantly
associated
with
an
increased
risk
contrast-induced
nephropathy
(CIN)
(OR
=
2.24,
95%
CI:
1.82–2.77)
chronic
disease
(CKD)
(RR
1.46,
1.32–1.63).
High
type
2
diabetes
mellitus
(T2DM)
3.53,
2.74–4.54),
gestational
(GDM)
2.41,
1.48–3.91),
diabetic
retinopathy
(DR)
2.34,
1.31–4.19).
Regarding
metabolic
diseases,
higher
patients
obstructive
sleep
apnea
(OSA)
(SMD
0.86,
0.57–1.15),
syndrome
(MD
0.83,
0.74–0.93),
non-alcoholic
fatty
liver
(NAFLD)
2.36,
1.88–2.97)
compared
those
these
conditions.
In
cerebrovascular
dementia
1.14,
1.12–1.16),
cognitive
impairment
2.31,
1.38–3.86),
ischemic
stroke
1.37,
1.22–1.54).
cardiovascular
showed
heart
failure
(HF)
(HR
1.21,
1.12–1.30),
atrial
fibrillation
(AF)
1.22,
0.57–1.87),
hypertension
(HTN)
1.52,
1.25–1.85).
is
promising
for
screening
predicting
medical
conditions,
particularly
related
insulin
resistance
disorders.
However,
heterogeneity
suggest
need
further
high-quality
research
confirm
refine
utility
index.
Abstract
Main
conclusion
Plant
Biomarkers
are
objective
indicators
of
a
plant’s
cellular
state
in
response
to
abiotic
and
biotic
stress
factors.
They
can
be
explored
crop
breeding
engineering
produce
stress-tolerant
species.
Global
food
production
safely
sustainably
remains
top
priority
feed
the
ever-growing
human
population,
expected
reach
10
billion
by
2050.
However,
factors
negatively
impact
systems,
causing
between
70
100%
reduction
yield.
Understanding
plant
responses
is
critical
for
developing
novel
crops
that
adapt
better
various
adverse
environmental
conditions.
Using
biomarkers
as
measurable
external
stimuli
could
serve
early
warning
signals
detect
stresses
before
severe
damage
occurs.
have
received
considerable
attention
last
decade
pre-stress
economically
important
crops.
This
review
discusses
some
associated
with
conditions
highlights
their
importance
stress-resilient
In
addition,
we
highlighted
influencing
expression
plants
under
stress.
The
information
presented
this
would
educate
researchers,
breeders,
agronomists
on
significance
biology
research,
which
essential
improving
growth
yield
toward
sustainable
production.
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 258 - 258
Опубликована: Янв. 15, 2024
Sickle
cell
disease
(SCD),
a
distinctive
and
often
overlooked
illness
in
the
21st
century,
is
congenital
blood
disorder
characterized
by
considerable
phenotypic
diversity.
It
comprises
group
of
disorders,
with
sickle
anemia
(SCA)
being
most
prevalent
serious
genotype.
Although
there
have
been
some
systematic
reviews
global
data,
worldwide
statistics
regarding
SCD
prevalence,
morbidity,
mortality
remain
scarce.
In
developed
countries
lower
number
patients,
cutting-edge
technologies
led
to
development
new
treatments.
However,
developing
settings
where
(SCD)
more
prevalent,
medical
management,
rather
than
cure,
still
relies
on
use
hydroxyurea,
transfusions,
analgesics.
This
that
affects
red
cells,
consequently
affecting
organs
diverse
manners.
We
discuss
its
etiology
advent
technologies,
but
aim
this
study
understand
various
types
nutrition-related
studies
involving
individuals
suffering
from
SCD,
particularly
Africa.
The
interplay
environment,
food,
gut
microbiota,
along
their
respective
genomes
collectively
known
as
microbiome,
host
metabolism
responsible
for
mediating
metabolic
phenotypes
modulating
microbiota.
addition,
it
serves
purpose
providing
essential
nutrients.
Moreover,
engages
direct
interactions
homeostasis
immune
system,
well
indirect
via
metabolites.
Nutrition
interventions
nutritional
care
are
mechanisms
addressing
increased
nutrient
expenditures
important
aspects
supportive
management
patients
SCD.
Underprivileged
areas
Sub-Saharan
Africa
should
be
accompanied
efforts
define
promote
Their
importance
key
maintaining
well-being
quality
life,
especially
because
products
limited,
while
native
medicinal
plant
resources
acknowledged.
Biomolecules,
Год журнала:
2024,
Номер
14(3), С. 277 - 277
Опубликована: Фев. 26, 2024
In
recent
years,
EVs
have
emerged
as
promising
vehicles
for
coding
and
non-coding
RNAs
(ncRNAs),
which
demonstrated
remarkable
potential
biomarkers
various
diseases,
including
chronic
liver
diseases
(CLDs).
are
small,
membrane-bound
particles
released
by
cells,
carrying
an
arsenal
of
ncRNAs,
microRNAs
(miRNAs),
long
(lncRNAs),
other
ncRNA
species,
such
piRNAs,
circRNAs,
tsRNAs.
These
ncRNAs
act
key
regulators
gene
expression,
splicing,
translation,
providing
a
comprehensive
molecular
snapshot
the
cells
origin.
The
non-invasive
nature
EV
sampling,
typically
via
blood
or
serum
collection,
makes
them
highly
attractive
candidates
clinical
biomarker
applications.
Moreover,
EV-encapsulated
offer
unique
advantages
over
traditional
cell-free
due
to
their
enhanced
stability
within
EVs,
hence
allowing
detection
in
circulation
extended
periods
enabling
more
sensitive
reliable
measurements.
Numerous
studies
investigated
EV-enclosed
CLD.
MiRNAs,
particular,
gained
significant
attention
ability
rapidly
respond
changes
cellular
stress
inflammation,
hallmarks
CLD
pathogenesis.
Elevated
levels
specific
miRNAs
been
consistently
associated
with
subtypes,
metabolic
dysfunction-associated
steatotic
disease
(MASLD),
steatohepatitis
(MASH),
hepatitis
B
C.
LncRNAs
also
transcripts
involved
wide
range
processes,
regeneration,
fibrosis,
cancer
progression.
Studies
shown
that
lncRNA
expression
profiles
can
distinguish
between
different
valuable
insights
into
progression
therapeutic
response.
Promising
included
miR-122
(elevated
MASLD
fibrosis),
miR-21
(increased
is
linked
inflammation
fibrosis
patients),
miR-192
advanced
stages
CLD,
cirrhosis
HCC),
LncRNA
HOTAIR
MASH
development),
H19
(dysregulation
HCC
progression).
present
review,
we
focus
on
tools
diagnosis
monitoring
etiologies.
Exploration of Neuroprotective Therapy,
Год журнала:
2024,
Номер
unknown, С. 119 - 147
Опубликована: Апрель 16, 2024
Degeneration
and
dysfunction
of
neurons
in
the
brain
are
hallmarks
neurodegenerative
diseases.
Over
past
decades,
significant
efforts
have
been
devoted
to
development
validation
biomarkers
for
The
range
diversity
central
nervous
system
(CNS)
diseases
has
continued
expand,
encompassing
biofluid-based
sources
such
as
blood
or
cerebrospinal
fluid
(CSF),
nucleic
acids,
tissues,
imaging.
While
imaging
tissue
biopsy-based
markers
continually
being
identified
their
applications
expanding,
they
do
limitations
compared
with
RNA
protein
biomarkers.
This
review
comprehensively
summarizes
various
biomarkers,
including
microRNA
(miRNA),
long
noncoding
(lncRNA),
circulating
miRNA
(cimiRNA),
proteins,
context
CNS
disorders.
In
addition,
emphasizes
existing
challenges
associated
use
both
clinical
practice
research
on
conclusion,
this
provides
an
insightful
overview
diseases,
underscoring
crucial
role
biomarker
combating
these
debilitating
conditions.
article
also
highlights
future
related
implementation
novel
trials,
thereby
contributing
ongoing
advance
understanding
management
Cancers,
Год журнала:
2024,
Номер
16(5), С. 862 - 862
Опубликована: Фев. 21, 2024
The
concept
and
policies
of
multicancer
early
detection
(MCED)
have
gained
significant
attention
from
governments
worldwide
in
recent
years.
In
the
era
burgeoning
artificial
intelligence
(AI)
technology,
integration
MCED
with
AI
has
become
a
prevailing
trend,
giving
rise
to
plethora
products.
However,
due
heterogeneity
both
targets
technologies,
overall
diversity
products
remains
considerable.
types
encompass
protein
biomarkers,
cell-free
DNA,
or
combinations
these
biomarkers.
development
models,
different
model
training
approaches
are
employed,
including
datasets
case-control
studies
real-world
cancer
screening
datasets.
Various
validation
techniques,
such
as
cross-validation,
location-wise
validation,
time-wise
used.
All
factors
show
impacts
on
predictive
efficacy
AIs.
After
completion
development,
deploying
AIs
clinical
practice
presents
numerous
challenges,
presenting
reports,
identifying
potential
locations
tumors,
addressing
cancer-related
information,
follow-up
treatment.
This
study
reviews
several
mature
currently
available
market,
detecting
their
composing
serum
biomarker
detection,
training/validation,
application.
review
illuminates
challenges
encountered
by
existing
across
stages,
offering
insights
into
continued
obstacles
within
field
AI.
Expert Reviews in Molecular Medicine,
Год журнала:
2024,
Номер
26
Опубликована: Янв. 1, 2024
Osteoarthritis
(OA)
commonly
affects
the
knee
and
hip
joints
accounts
for
19.3%
of
disability-adjusted
life
years
lived
with
disability
worldwide
(Refs
1,
2).
Early
management
is
important
in
order
to
avoid
uphold
quality
(Ref.
3).
However,
a
lack
awareness
subclinical
early
symptomatic
stages
OA
often
hampers
4).
Moreover,
late
diagnosis
among
those
severe
disease,
at
stage
when
becomes
more
complicated
common
5,
6,
7,
8).
Established
risk
factors
development
progression
include
increasing
age,
female,
history
trauma
obesity
9).
Recent
studies
have
also
drawn
link
between
metabolic
syndrome,
which
characterized
by
insulin
resistance,
dyslipidaemia
hypertension
10,
11).
