iScience,
Год журнала:
2024,
Номер
27(12), С. 111477 - 111477
Опубликована: Ноя. 26, 2024
5-Aminolevulinic
acid
(5-ALA)
is
an
essential
compound
in
the
biosynthesis
of
heme,
playing
a
critical
role
various
physiological
processes
within
human
body.
This
review
provides
thorough
analysis
latest
research
on
molecular
mechanisms
and
potential
therapeutic
benefits
5-ALA
managing
metabolic
disorders.
The
ability
to
influence
immune
response
inflammation,
oxidative/nitrosative
stress,
antioxidant
system,
mitochondrial
functions,
as
well
carbohydrate
lipid
metabolism,
mediated
by
associated
with
suppression
transcription
factor
NF-κB
signaling
pathway,
activation
Nrf2/heme
oxygenase-1
(HO-1)
system
leading
formation
heme-derived
reaction
products
(carbon
monoxide,
ferrous
iron,
biliverdin,
bilirubin),
which
may
contribute
HO-1-dependent
cytoprotection
through
immunomodulatory
effects.
Additionally,
it
regulates
expression
peroxisome
proliferator-activated
receptor
gamma
coactivator
1-alpha,
cytochrome
Animals,
Год журнала:
2025,
Номер
15(3), С. 303 - 303
Опубликована: Янв. 22, 2025
Upcycling
brewers’
spent
grain
(BSG)
into
poultry
feed
needs
to
be
optimized.
Since
broiler
chickens
inefficiently
digest
fiber,
we
created
a
water-soluble
BSG
extract
(BSGE)
explore
this
fraction’s
potential
nutritional
benefits.
We
utilized
intra-amniotic
administration
(in
ovo)
target
the
gastrointestinal
tract
of
embryos.
BSGE
increased
villus
surface
area
and
goblet
cell
quantity
size,
implying
improved
duodenal
development.
The
also
changed
cecal
Escherichia
coli
(E.
coli)
Clostridium
abundances.
Synchrotron
X-ray
fluorescence
microscopy,
along
with
zinc
iron
transporter
relative
expression,
did
not
reveal
significant
changes
by
BSGE.
These
findings
highlight
for
functional
component,
underscoring
value
upcycling
byproduct.
This
pilot
study
supports
future
work
exploring
impact
within
its
effects
over
long-term
consumption.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25058 - e25058
Опубликована: Янв. 21, 2024
The
purpose
of
this
inquiry
is
to
provide
a
conprehensive
summary
and
analysis
the
literature
concerning
pharmacological
properties
components
that
can
be
extracted
from
Desmodium
styracifolium,
preparation
in
Chinese
medicine.
This
study
also
aims
explore
their
potential
application
elaborating
medicinal
products
for
effective
prevention
treatment
such
conditions
as
urolithiasis,
cholelithiasis,
type
2
diabetes
mellitus,
metabolic
syndrome,
pro-oxidant
inflammatory
processes,
etc.Several
experimental
studies
confirmed
D.
styracifolium
influence
mineral
metabolism,
decrease
concentration
constituents
involved
formation
urinary
calculi,
reduce
encrustation
tract,
well
alleviate
damage
caused
by
crystal
structures.
beneficial
impact
achieved
through
combination
antioxidant
anti-inflammatory
actions,
along
with
urine
alkalinization.
cholelitholytic,
choleretic,
hepatoprotective
effects
plants
have
been
confirmed,
primarily
ascribed
activation
hepatic
Xα
receptor
bile
acid
receptor,
farnesoid
X
flavonoid
shaftoside.Special
attention
focused
on
therapeutic
applications
flavonoids
derived
diseases
associated
development
chronic
inflammation
systemic
response,
emphasizing
ability
exert
acting
directly
modulation
transcription
factors.It
concluded
new
strategies
acute
processes
may
rely
promising
dosage
forms
subsequent
preclinical
clinical
trials.
PAIN JOINTS SPINE,
Год журнала:
2025,
Номер
14(4), С. 193 - 198
Опубликована: Янв. 2, 2025
Background.
Osteoarthritis
(OA)
is
one
of
the
most
common
joint
diseases
worldwide.
The
search
for
effective
treatment
regimens
to
reduce
symptoms
and
improve
function
essential.
purpose
was
compare
effectiveness
different
bioactive
marine
fish
concentrate
(BMFC)
in
knee
OA
with
oral
glucosamine
sulfate
(GS)
chondroitin
(CS).
Materials
methods.
study
involved
60
patients
stage
II
OA.
were
divided
into
three
groups:
first
group
received
1
ml
BMFC
daily
(20
injections),
second
2
every
other
day
(10
third
GS
CS
tablet
form.
Clinical
efficacy
assessed
using
WOMAC
scale
on
days
3,
7,
14,
21.
Results.
In
that
daily,
pain
decreased
by
41.4
%
7
58.7
Joint
stiffness
51.9
%,
range
motion
increased
51.3
%.
receiving
day,
reduction
37.1
55.7
49.2
improved
46.0
end
treatment.
Both
groups
demonstrated
similar
efficacy.
Patients
showed
less
pronounced
improvements.
Conclusions.
Injectable
higher
treating
compared
CS.
BMFC
administration
(daily
day)
proved
reducing
pain,
alleviating
stiffness,
improving
functional
capacity.
every-other-day
regimen
achieved
comparable
fewer
injections,
enhancing
convenience
adherence
therapy.
Antioxidants,
Год журнала:
2023,
Номер
12(7), С. 1383 - 1383
Опубликована: Июль 4, 2023
Interest
in
the
extraction
of
phytochemical
bioactive
compounds,
especially
polyphenols
from
biomass,
has
recently
increased
due
to
their
valuable
biological
potential
as
natural
sources
antioxidants,
which
could
be
used
a
wide
range
applications,
foods
and
pharmaceuticals
green
polymers
bio-based
materials.
The
present
research
study
aimed
provide
comprehensive
chemical
characterization
composition
forest
biomass
(bark
needles)
softwood
species
(Picea
abies
L.,
H.
Karst.,
Abies
alba
Mill.)
investigate
vitro
antioxidant
antimicrobial
activities
assess
treating
healing
infected
chronic
wounds.
DPPH
radical-scavenging
method
P–LD
were
for
mechanistic
explanation
biomolecular
effects
investigated
compounds.
(+)-Catechin,
epicatechin,
rutin,
myricetin,
4
hydroxybenzoic
p-cumaric
acids,
kaempherol,
apigenin
main
quantified
coniferous
(in
quantities
around
100
µg/g).
Also,
numerous
phenolic
flavonoids,
stilbenes,
terpenes,
lignans,
secoiridoids,
indanes
with
antioxidant,
antimicrobial,
anti-inflammatory,
antihemolytic,
anti-carcinogenic
identified.
needle
extract
was
more
toxic
microbial
strains
than
eukaryotic
cells
that
its
active
wound
principles.
In
this
context,
developing
industrial
upscaling
strategies
is
imperative
long-term
success
biorefineries
incorporating
them
part
circular
bio-economy.
Reumatologia/Rheumatology,
Год журнала:
2023,
Номер
61(5), С. 395 - 407
Опубликована: Окт. 31, 2023
Post-traumatic
osteoarthritis
(PTOA),
a
disorder
of
the
synovium,
subchondral
bone,
and
cartilage
that
affects
entire
joint,
constitutes
approximately
12%
all
cases
symptomatic
osteoarthritis.
This
review
summarizes
pathogenetic
mechanisms
underlie
positive
influence
chondroitin
sulphates
(CSs)
on
PTOA
as
means
preventive
therapeutic
treatment.
Mechanisms
development
involve
chondrocytes
undergoing
various
forms
cell
death
(apoptosis,
pyroptosis,
necroptosis,
ferroptosis
and/or
necrosis).
Chondroitin
are
class
glycosaminoglycans
improve
structure
function
which
is
associated
with
their
ability
to
decrease
activation
NF-κB
p38
MAPK,
up-regulate
Nrf2.
Standardized
small
fish
extract
(SSFE)
an
example
drugs
can
attenuate
NF-κB-mediated
systemic
inflammation,
potentially
helping
reduce
joint
inflammation
degradation,
function,
alleviate
pain
disability
in
patients
these
conditions.
Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії,
Год журнала:
2023,
Номер
23(3), С. 137 - 142
Опубликована: Ноя. 3, 2023
In
an
experiment
on
42
white
rats,
the
mechanisms
of
oxidative-nitrosative
stress
in
liver
tissues
under
conditions
surgical
trauma
reproduced
background
post-traumatic
disorder
were
studied.
It
has
been
shown
that
reproduction
experimental
model
posttraumatic
(single
prolonged
stress)
causes
development
rat
tissues:
it
increases
rate
superoxide
anion
radical
generation
by
microsomes,
mitochondria
and
leukocyte
NADPH
oxidase,
NO-synthase
activity
activating
inducible
isoform,
reduces
conjugation
constitutive
NO-synthases,
which
is
accompanied
increase
concentration
peroxynitrites
alkaline
alkaline-earth
metals.
On
7th
day
after
laparotomy
against
disorder,
indicators
tissues,
such
as
production
microsomes
oxidase
total
metals,
significantly
exceed
their
values
a
single
sham
operation
simulated
stress.
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(2)
Опубликована: Фев. 19, 2025
Pediatric
asthma
is
a
common
respiratory
condition
in
children,
characterized
by
complex
interplay
of
environmental
and
genetic
factors.
Evidence
shows
that
the
airways
stimulated
asthmatic
patients
have
increased
oxidative
stress,
but
exact
mechanisms
through
which
this
stress
contributes
to
progression
are
not
fully
understood.
Oxidative
originates
from
inflammatory
cells
airways,
producing
significant
amounts
reactive
oxygen
species
(ROS)
nitrogen
(RNS).
External
factors
such
as
cigarette
smoke,
particulate
matter,
atmospheric
pollutants
also
contribute
ROS
RNS
levels.
The
accumulation
these
disrupts
cellular
redox
balance,
leading
heightened
activates
signaling
pathways
modulates
release
factors,
worsening
inflammation.
Therefore,
understanding
sources
impacts
pediatric
crucial
developing
antioxidant-based
treatments.
This
review
examines
children
with
asthma,
role
development,
potential
antioxidants
therapeutic
strategy
for
asthma.