Colloidal Drug Delivery System: An Overview DOI

Shikha Pandey,

Puja Nayak,

Akanksha Malaiya

et al.

Published: Jan. 1, 2024

Language: Английский

Innovative PEGylated chitosan nanocarriers for co-delivery of doxorubicin and CpG in breast cancer therapy: Preparation, characterization, and immunotherapeutic potential DOI
Sitah Alharthi, Amal Abdullah Alrashidi, Zyta M. Ziora

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 23, 2025

Language: Английский

Citations

1

Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric Drug Delivery to Treat Drug Resistant Chondrosarcoma In Vivo DOI
Jiahui Zhu, Ran Wei, Guang Hu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(31)

Published: March 8, 2024

Abstract Chondrosarcoma(CS), a prevalent primary malignant bone tumor, frequently exhibits chemotherapy resistance attributed to upregulated anti‐apoptosis pathways such as the Bcl‐2 family. In this manuscript, new strategy is presented augment chemosensitivity and mitigate systemic toxicity by harnessing nano‐enabled drug delivery hydrogel platform. The platform utilizes “PLGA‐PEG‐PLGA”, an amphiphilic triblock copolymer combining hydrophilic polyethylene glycol (PEG) hydrophobic polylactide glycolide (PLGA) blocks, renowned for its properties conducive crafting biodegradable, temperature‐sensitive hydrogel. This tailored encapsulate ratiometrically designed dual‐loaded liposomes containing first‐line chemo option CS, Doxorubicin (Dox), plus calculated amount of small molecule inhibitor anti‐apoptotic pathway, ABT‐737. vitro in vivo evaluations demonstrate successful suppression, resulting restoration Dox sensitivity, evident through impeded tumor growth amplified necrosis rates at site. system showcases remarkable thermal responsiveness, injectability, biodegradability, all finely aligned with clinical demands CS treatment. Collectively, study introduces transformative avenue tackling chemotherapy, offering significant potential.

Language: Английский

Citations

5

Electrochemical Sensor for the Evaluation of Doxorubicin from Novel Pharmaceutical Formulations and Serum DOI Creative Commons
Alexandra Pusta, Mihaela Tertiş,

Irina Bura

et al.

Chemosensors, Journal Year: 2024, Volume and Issue: 12(4), P. 69 - 69

Published: April 19, 2024

This study focuses on addressing the challenges associated with doxorubicin (DOX), an anthracycline chemotherapeutic widely used in cancer treatment. Despite its efficacy, DOX is linked to severe side effects that limit clinical applications. Novel pharmaceutical formulations aim mitigate these issues, providing better safety profiles. The development of requires analytical methods can accurately and quickly quantify DOX. A cost-effective portable electrochemical sensor for detection was developed utilizing in-house printed carbon electrodes decorated gold nanoparticles. detected using differential pulse voltammetry. demonstrated accurate quantification from novel serum, presenting a dynamic range 1 500 μg/mL low 0.3 μg/mL. method, successfully applied characterize DOX-loaded nanosomes, offers valuable alternative early stages formulation development, reducing costs saving time, while maintaining accuracy.

Language: Английский

Citations

4

Enhancing the efficacy of letrozole-loaded PEGylated nanoliposomes against breast cancer cells: In vitro study DOI Creative Commons

Soraya Shahbazi,

Farzaneh Tafvizi, Vahid Naseh

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30503 - e30503

Published: April 30, 2024

Considering its overall impact on human health, letrozole (Let) has been described as having significant efficacy that could be improved by developing drug delivery systems. the side effects of Let, this study aims to encapsulate Let in liposomes and PEGylated liposome nanoparticles (Lipo-Let-PEG) evaluate cytotoxic MCF-7 breast cancer cell line. For purpose, Lipo-Let-PEG formulation was designed characterized SEM, DLS, FTIR methods, release from optimized stability were measured. Furthermore, cytotoxicity apoptotic studies performed using MTT assay flow cytometric analysis. According experimental data, vesicle size EE% 170.05 ± 4.15 nm 87.21 1.36%, respectively. The cumulative at pH 5.4 7.4 also approximately 60% 50%, results showed Lip-Let-PEG produced more than Lip-Let against cells compatible with normal cells. apoptosis cycle arrest cytometry show caused most increase rates compared other treated groups. In conclusion, can used an anticancer agent arresting progression inducing apoptosis, which applied future prevent development.

Language: Английский

Citations

4

Looking back, moving forward: protein corona of lipid nanoparticles DOI
Yue Gao,

Yeqi Huang,

Chuanyu Ren

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(23), P. 5573 - 5588

Published: Jan. 1, 2024

Intelligent delivery of lipid nanoparticles can be achieved through rational design protein corona as a “troublemaker”.

Language: Английский

Citations

4

Preparation and characterization of nisin‐loaded chitosan nanoparticles functionalized with DNase I for the removal of Listeria monocytogenes biofilms DOI
Xin Hu,

Xueying Du,

Mingwei Li

et al.

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(4), P. 2305 - 2315

Published: Feb. 19, 2024

Listeria monocytogenes biofilms represent a continuous source of contamination, leading to serious food safety concerns and economic losses. This study aims develop novel nisin-loaded chitosan nanoparticles (CSNPs) functionalized with DNase I evaluate its antibiofilm activity against L. on contact surfaces. Nisin-loaded CSNPs (CS-N) were first prepared by ionic cross-linking, was covalently grafted the surface (DNase-CS-N). The NPs subsequently characterized Zetasizer Nano, transmission electron microscopy, Fourier transform infrared (FT-IR), X-ray diffraction (XRD). evaluated polyurethane (PU). DNase-CS-N fabricated quality attributes (particle size-427.0 ± 15.1 nm, polydispersity [PDI]-0.114 0.034, zeta potential-+52.5 0.2 mV, encapsulation efficiency-46.5% 3.6%, conjugate rate-70.4% 0.2). FT-IR XRD verified loading nisin binding chitosan. caused 3 log colony-forming unit (CFU)/cm2 reduction biofilm cells, significantly higher than those in (1.4 log), CS-N (1.8 combination (2.2 log) treatment groups. In conclusion, successfully smooth nearly spherical shape, high positive charge, good stability, which is effective eradicate cells surfaces, exhibiting great potential as agents industry. PRACTICAL APPLICATION: are common hazard processing. this study, constructed expected be promising agent

Language: Английский

Citations

3

Lipid-based drug delivery for lungs cancer DOI
Mohd Sayeed Shaikh,

Rupesh R. Kurhade,

Shaikh Shahbaz A. Majeed

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 153 - 189

Published: Jan. 1, 2025

Language: Английский

Citations

0

Cisplatin meets liposomes for a smarter delivery: A review DOI Creative Commons

Marta Stępień,

Joanna Zajda, Bernhard K. Keppler

et al.

Talanta, Journal Year: 2025, Volume and Issue: 295, P. 128331 - 128331

Published: May 14, 2025

Language: Английский

Citations

0

Preparation of RGD-modified liposomes encapsulated with shikonin and its targeted anti-melanoma effects DOI Creative Commons
Hao Zhang, Ying Zhao, Tingting Chen

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 27, 2025

Melanoma is the most aggressive skin tumor, and conventional treatment ineffective. Studies have shown that shikonin, derived from traditional Chinese medicine Lithospermum erythrorhizon , has various anticancer activities. In this work, RGD- modified liposomes encapsulated with shikonin (RGD-Lip-SHK) were prepared by thin- film dispersion, which could highly recognize integrin α V β 3 on surface of melanoma cells. RGD-Lip-SHK appeared as spheroid-like vesicles a particle size approximately 120 nm, its ξ-potential was negative. remained stable in serum within 48 h possessed sustained-release effect. vitro compared non -targeted (Lip-SHK), more efficiently taken up, had higher cytotoxicity, better targeted to inhibit cell growth, migration, invasion, boost apoptosis regulating expression Bcl-2 Bax proteins vivo strongest anti-melanoma effect -mediated endocytosis long circulation time inhibited tumor growth B16F10 tumor-bearing mice other groups. Furthermore, histology major organs body weight showed less toxicity. summary, these results indicated great potential for melanoma, expected become novel effective strategy tumor-targeted therapy.

Language: Английский

Citations

0

Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example DOI
Ghadha Ibrahim Fouad, Maha Z. Rizk

Journal of Molecular Histology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

1