The Microbe, Год журнала: 2024, Номер 5, С. 100204 - 100204
Опубликована: Ноя. 17, 2024
Язык: Английский
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Май 31, 2024
Postmenopausal osteoporosis is a prevalent disease that affects the bone health of middle-aged and elderly women. The link between gut microbiota health, known as gut-bone axis, has garnered widespread attention.
Язык: Английский
Процитировано
5
Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(4)
Опубликована: Июнь 7, 2024
Abstract Dairy is recognized as a good source of calcium, which important for preventing osteoporosis. However, the relationship between milk and bone health more complex than just calcium supplementation. It unwise to focus solely on observing effects single nutrient. Lactose, proteins, vitamins in milk, well fatty acids, oligosaccharides, exosomes, all work together with enhance its bioavailability utilization efficiency through various mechanisms. We evaluate roles dairy nutrients active ingredients maintaining homeostasis from perspective matrix effects. Special attention given threshold effects, synergistic associations gut–bone axis. also summarize probiotic/prebiotic low‐fat/high‐fat lactose‐free fortified reduced risk osteoporosis discuss potential benefits controversies these products. Moreover, we examine role products increasing peak mass during adolescence reducing loss old age. provides theoretical reference use accurate prevention management related chronic diseases offers personalized dietary recommendations different populations.
Язык: Английский
Процитировано
5
World Journal of Orthopedics, Год журнала: 2025, Номер 16(3)
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
0
Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115388 - 115388
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Medicine, Год журнала: 2025, Номер 104(10), С. e41703 - e41703
Опубликована: Март 7, 2025
Emerging evidence indicates an association between the gut microbiota and incidence of osteonecrosis (ON), yet literature has not adequately addressed whether this relationship is causal. This study uses data from MiBioGen Consortium UK Biobank for Mendelian randomization (MR) analysis to identify pathogenic microbial taxa associated with ON. Sensitivity analyses confirmed causal relationships, while reverse MR ruled out causation. SNP annotation located genetic variants linked instrumental variables in The inverse variance weighted method revealed 5 a ON, including order Erysipelotrichales (OR = 2.24, 95% CI 1.16-4.32, P .02), genus Christensenellaceae R 0.41, 0.19-0.87, family Erysipelotrichaceae Family XIII 0.45, 0.21-0.95, .04), class Erysipelotrichia .02). mitigated concerns regarding heterogeneity, directional pleiotropy, outliers (P > .05). However, showed no effect ON on these taxa. (single-nucleotide polymorphism) pinpointed 20 host genes pathogenesis. These findings lay groundwork microbiota-targeted therapies deepen our understanding gut-bone axis osteonecrosis.
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Апрель 1, 2025
This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.
Язык: Английский
Процитировано
0
Gut Microbes, Год журнала: 2025, Номер 17(1)
Опубликована: Апрель 24, 2025
Osteoporosis is a systemic skeletal disease that leads to lower bone mineral density and intensifies the risk of unexpected fractures. Recently, our group reported numerical defect in frequencies Bregs along with their compromised tendency produce IL-10 cytokine further aggravates inflammatory loss post-menopausal osteoporosis (PMO). Dysbiosis induced mucosal injury leaky gut are predominant contributors involved progression diseases including PMO. Furthermore, several evidence suggest microbial composition plays crucial role development differentiation Bregs. Nevertheless, potential dysbiotic microbiota (GM) under estrogen deficient PMO conditions has never been deciphered. Here, we evaluated GM onset its modulating anti-osteoporotic We found enhancement endotoxin producing bacteria concomitant reduction short chain fatty acids bacteria, both pre-clinical clinical osteoporotic condition augment loss. This suggests dysbiosis potentially exacerbates deterioration conditions. Remarkably, supplementation probiotic Bacillus coagulans significantly improved density, strength, microarchitecture by anti-osteoclastogenic, immunosuppressive immunomodulatory The present study delves deeper into immune homeostasis ("Breg-Treg-Th17" cell axis) profile pathophysiology Altogether, findings open novel therapeutic avenues, suggesting restoration as one viable options mitigating via "Gut-Immune-Bone" axis.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Июль 15, 2024
Objective Osteoporosis, characterized by reduced bone density and heightened fracture risk, is influenced genetic environmental factors. This study investigates the interplay between gut microbiota, plasma metabolomics, osteoporosis, identifying potential causal relationships mediated metabolites. Methods Utilizing aggregated genome-wide association studies (GWAS) data, a comprehensive two-sample Mendelian Randomization (MR) analysis was performed involving 196 microbiota taxa, 1,400 metabolites, osteoporosis indicators. Causal were explored. Results The MR analyses revealed ten taxa associated with five positively linked to increased risk negatively associated. Additionally, 96 metabolites exhibited 49 showing positive associations 47 displaying negative associations. Mediation identified six pathways connecting through mediating seven distinct two of which demonstrated suppression effects. Conclusion provides suggestive evidence correlations links osteoporosis. findings underscore complex, multifactorial nature suggest metabolite profiles as biomarkers or therapeutic targets in management
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
The discovery of the bone-gut axis linking bone metabolism to gut microbiota (GM) dysbiosis has revolutionized our understanding managing degenerative skeletal diseases. Targeting GM regulation emerged as a promising approach osteoporosis treatment. Herein, we develop propolis nanoemulsions (PNEs) with enhanced gastrointestinal stability and oral bioavailability for GM-based therapy. Orally administered PNEs exhibit superior antiosteoporosis efficacy in an ovariectomized (OVX) mouse model by modulating structure metabolites restoring intestinal barrier function. Multiomics analysis reveals that reduction
Язык: Английский
Процитировано
2
The Microbe, Год журнала: 2024, Номер 5, С. 100204 - 100204
Опубликована: Ноя. 17, 2024
Язык: Английский
Процитировано
0