Academic Radiology, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(12), С. 100964 - 100964
Опубликована: Март 12, 2024
Urinary system tumors include malignancies of the bladder, kidney, and prostate, present considerable challenges in diagnosis treatment. The conventional therapeutic approaches against urinary are limited by lack targeted drug delivery significant adverse effects, thereby necessitating novel solutions. Intelligent nanomedicine has emerged as a promising alternative for cancer recent years, uses nanoscale materials to overcome inherent biological barriers tumors, enhance diagnostic accuracy. In this review, we have explored advances applications intelligent diagnosis, imaging, treatment tumors. principles design pertaining encapsulation, targeting controlled release been discussed, with emphasis on strategies overcoming renal clearance tumor heterogeneity. Furthermore, nanomedicine, its advantages over traditional chemotherapy, currently facing clinical translation such safety, regulation scalability, also reviewed. Finally, assessed potential management emphasizing emerging trends personalized combination therapies. This comprehensive review underscores substantial contributions field oncology offers outlook more effective precise
Язык: Английский
Процитировано
5
BMC Cancer, Год журнала: 2022, Номер 22(1)
Опубликована: Сен. 26, 2022
Bladder cancer (BLCA) is one of the most common genitourinary malignancies in world, but its pathogenic genes have not been fully identified and treatment outcomes are still unsatisfactory. Although members 2', 5'-oligoadenylate synthetase (OAS) gene family known involved some tumorous biological processes, roles OAS BLCA undetermined.By combining vast bioinformatic datasets analyses experimental verification on clinical specimen, we expressions functions with comparison to normal bladder tissues.The expression levels were higher than tissues. The had correlations genomic mutation methylation, infiltration CD4 + T cells, CD8 neutrophils, dendritic cells microenvironment BLCA. In addition, high OAS1, OAS2, OAS3, OASL predicted better overall survival patients.The highly expressed can reflect immune tumor predict BLCA, thus may be considered as a signature study provides new insights into diagnosis, treatment, prognosis
Язык: Английский
Процитировано
18
Talanta, Год журнала: 2023, Номер 268, С. 125296 - 125296
Опубликована: Окт. 7, 2023
Язык: Английский
Процитировано
10
Cancer Genetics, Год журнала: 2024, Номер 288-289, С. 43 - 53
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
4
International Journal of Radiation Biology, Год журнала: 2024, Номер 100(5), С. 791 - 801
Опубликована: Март 5, 2024
Purpose Radiotherapy with bladder preservation is highly acceptable among patients bearing cancer (BCa), but the occurrence of secondary tolerance (ARR) during treatment one important reasons for failure clinical radiotherapy. COX-2 has been frequently reported to be expressed and associated radio-resistance in various cancers. In this study, feasibility Taraxasterol (Tara) as a radiosensitizer was investigated, target effect Tara on its underlying mechanism were explored.
Язык: Английский
Процитировано
3
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Май 12, 2024
Abstract Background A greater emphasis has been placed on the part of cell cycle progression (CCP) in cancer recent years. Nevertheless, precise connection between CCP-related genes and bladder (BCa) remained elusive. This study endeavors to establish validate a reliable risk model incorporating factors, aiming predict both prognosis immune landscape BCa. Methods Clinical information RNA sequencing data were collected from GEO TCGA databases. Univariate multivariate Cox regression analyses conducted construct associated with CCP. The performance was assessed using ROC Kaplan–Meier survival analyses. Functional enrichment analysis employed investigate potential cellular functions signaling pathways. characterized CIBERSORT algorithms. Integration various clinical variables led development nomogram. Results To build model, three (RAD54B, KPNA2, TPM1) carefully chosen. confirm that our good performance. About immunological infiltration, high-risk group showed decreased levels regulatory T cells dendritic coupled increased activated CD4 + memory cells, M2 macrophages, neutrophils. Furthermore, nomogram impressive predictive power for OS at 1, 3, 5 Conclusion provides new insights into association BCa, as well its impact landscape.
Язык: Английский
Процитировано
3
Experimental and Molecular Pathology, Год журнала: 2024, Номер 137, С. 104904 - 104904
Опубликована: Май 25, 2024
Pelvic malignancies consistently pose significant global health challenges, adversely affecting the well-being of male population. It is anticipated that clinicians will continue to confront these cancers in their practice. Nanomedicine offers promising strategies revolutionize treatment pelvic by providing precise delivery methods aim improve efficacy therapeutic outcomes while minimizing side effects. Nanoparticles are designed encapsulate agents and selectively target cancer cells. They can also be loaded with theragnostic agents, enabling multifunctional capabilities.
Язык: Английский
Процитировано
3
Molecular Carcinogenesis, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
ABSTRACT Bladder cancer (BCa) is an aggressive malignancy of urinary system. Aerobic glycolysis refers to the phenomenon wherein cells increase glucose consumption and produce lactic acid. Our study focused on role mechanism circST6GALNAC6 in BCa glycolysis. The 24 h intake was detected using flow cytometry. Lactic acid ATP were utilizing commercially provided kits. Extracellular acidification rate measured Seahorse XF‐96p Flux Analyzer. Cell proliferation determined colony formation assay. RNA immunoprecipitation co‐immunoprecipitation experiments adopted validate molecular interactions. BALB/C nude mice utilized establish xenograft tumor model. CircST6GALNAC6 decreased cells, overexpression inhibited cells. Additionally, promoted degradation glycolytic regulatory protein HK1 its expression, PRKN facilitated ubiquitination‐related HK1. enhanced mRNA stability expression by recruiting FUS. Furthermore, inhibitory impact reversed knockdown. Finally, suppressed growth through increasing mice. FUS/PRKN/HK1 axis. Targeting holds promise as a novel approach for treating BCa.
Язык: Английский
Процитировано
0
Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123597 - 123597
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Medicine, Год журнала: 2025, Номер 104(12), С. e41907 - e41907
Опубликована: Март 21, 2025
There was currently no bibliometric analysis available regarding to bladder cancer (BCa) imaging. The aim of this study conduct a comprehensive relevant literature on the imaging BCa and elucidate global research hotspots further trends in field. All published between 1981 2023 were retrieved from Web Science Core Collection. VOSviewer, Bibliometrix, Citespace utilized for publications, countries, authors, institutions, journals, references, keywords. A total 4462 articles retrieved. field has been increasing consistently since 1981. United States America most productive country institutions it. Shariat SF author with 36 highest co-citations Herr HW (472). Journal Urology journal Frontiers Oncology, Abdominal Radiology Cancers exhibited heightened activity recent years. by Siegel RL, CA-A Cancer Clinicians 2019, had number co-citations. Further keyword timeline view revealed that "radiomics," "deep learning," "multiparametric MRI," "VI-RADS," "muscle-invasive cancer," "immunotherapy," "long term outcome" hotspots. In totally, period year, USA occupies critical position It is anticipated MRI-based imaging-reporting data system deep learning will be future.
Язык: Английский
Процитировано
0