Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study

Journal of Medical Virology, Год журнала: 2024, Номер 96(3)

Опубликована: Март 1, 2024

Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and hypotension (OH), are often reported in long covid, but published studies small with inconsistent results. We sought to estimate the prevalence of objective OI patients attending covid clinics healthy volunteers associations symptoms comorbidities. Participants a diagnosis were recruited from eight UK clinics, general population. All undertook standardized National Aeronautics Space Administration Lean Test (NLT). Participants' history typical (e.g., dizziness, palpitations) before during NLT recorded. Two hundred seventy-seven 50 frequency-matched tested. Healthy had no or PoTS, 10% asymptomatic OH. One thirty (47%) previous 144 (52%) developed NLT. Forty-one (15%) an abnormal NLT, 20 (7%) met criteria for 21 (8%) Of 45% prior OI. Relaxing diagnostic thresholds PoTS two consecutive readings one reading resulted 11% participants (an additional 4%) meeting not volunteers. More than half experienced more 10 either OH, whom did report symptoms. therefore recommend all offered appropriate management commenced.

Язык: Английский

---

Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 170 - 170

Опубликована: Янв. 31, 2024

Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of variety chronic, inflammatory diseases, including long COVID, as are small, insoluble, 'fibrinaloid' microclots. We here develop the argument, with accompanying evidence, that fibrinaloid microclots, through their ability to block flow blood microcapillaries and thus cause tissue hypoxia, not simply correlated but in fact, by preceding it, may be chief intermediary POTS, which body's exaggerated 'physiological' response hypoxia. Similar reasoning accounts for symptoms bundled under term 'fatigue'. Amyloids known membrane disruptors, when targets nerve membranes, this can explain neurotoxicity hence autonomic nervous system dysfunction contributes POTS. Taken together view, we indicate microclots serve link POTS fatigue COVID manner at once both mechanistic explanatory. This has clear implications treatment such diseases.

Язык: Английский

---

Impact of long COVID on the heart rate variability at rest and during deep breathing maneuver

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Дек. 20, 2023

Abstract While the majority of individuals with coronavirus disease 2019 (COVID-19) recover completely, a significant percentage experience persistent symptom, which has been characterized as Long COVID and may be associated cardiac autonomic dysfunction. We evaluated heart rate variability (HRV) at rest during deep-breathing (M-RSA) in patients COVID. Case–control design involved 21 20 controls; HRV was (POLAR system) supine position M-RSA expressed time domain non-linear analysis. In we found reduction measures COVID’ compared to controls for: Mean_iRR ( p < 0.001), STD_iRR 0.001); STD_HR SD1 SD2 alpha2 0.001). rMSSD RR_tri-index 0.001) except for highest Mean_HR 0.001. conclusion, reduced deep breathing. These findings imply impairment control when symptoms COVID-19 persist following initial recovery.

Язык: Английский

---

Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 15, 2023

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic neuropathic symptoms.

Язык: Английский

---

Mechanisms of long COVID: An updated review

Chinese Medical Journal - Pulmonary and Critical Care Medicine, Год журнала: 2023, Номер 1(4), С. 231 - 240

Опубликована: Дек. 1, 2023

The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3 years, with an enormous impact on global health and economies. In some patients, symptoms signs may remain after recovery from severe acute respiratory syndrome 2 (SARS-CoV-2) infection, which cannot be explained by alternate diagnosis; this condition defined as long COVID. Long COVID exist in patients both mild is prevalent infection different SARS-CoV-2 variants. most common include fatigue, dyspnea, other involving multiple organs. Vaccination results lower rates of To date, the mechanisms unclear. narrative review, we summarized clinical presentations current evidence regarding pathogenesis

Язык: Английский

---

Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies

European Heart Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity mortality. Its pathogenesis intricately linked to deleterious impact of cardiovascular risk factors, emphasizing pivotal imperative for early detection mitigation strategies targeting these factors prevention primary AF. While traditional are well recognized, an increasing number novel have been identified in recent decades. This review explores emerging non-traditional AF, including unhealthy lifestyle current society (sleep, night shift work, diet), biomarkers (gut microbiota, hyperuricaemia, homocysteine), adverse conditions or diseases (depression, epilepsy, clonal haematopoiesis indeterminate potential, infections, asthma), environmental (acoustic pollution other factors). Unlike individuals limited control over many posing challenges conventional strategies. The purpose this outline evidence on associations new-onset AF potential mechanisms related factors. Furthermore, aims explore interventions at both individual societal levels mitigate growing burden suggesting guideline updates prevention.

Язык: Английский

---

Rehabilitative interventions in patients with persistent post COVID-19 symptoms—a review of recent advances and future perspectives

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2023, Номер 274(8), С. 1819 - 1828

Опубликована: Июнь 16, 2023

The SARS-CoV-2 pandemic has not only caused millions of deaths but left also people with persistent symptoms behind. These long-term COVID-19 sequelae cause a considerable burden on individuals´ health, healthcare systems, and economies worldwide given the high rate infections. Therefore, rehabilitative interventions strategies are needed to counteract post sequelae. importance rehabilitation for patients been recently highlighted in Call Action by World Health Organisation. Based previously published research, line clinical experience, is one specific disease rather presents different phenotypes that vary their pathophysiological mechanisms, symptomatic manifestations, potential interventional approaches. This review provides proposal differentiating non-organ-specific may help clinicians evaluate plan therapeutic options. Furthermore, we present current unmet needs suggest pathway approach post-COVID symptoms.

Язык: Английский

---

COVID-19 and immune dysfunction: Consequences and natural remedies for management

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 235 - 264

Опубликована: Янв. 1, 2025

Язык: Английский

---

Long COVID and rheumatology: Clinical, diagnostic, and therapeutic implications

Best Practice & Research Clinical Rheumatology, Год журнала: 2022, Номер 36(4), С. 101794 - 101794

Опубликована: Ноя. 8, 2022

Язык: Английский

---

Cardiovascular Considerations in the Management of People With Suspected Long COVID

Canadian Journal of Cardiology, Год журнала: 2023, Номер 39(6), С. 741 - 753

Опубликована: Апрель 6, 2023

Язык: Английский

---