Metal complexes of saccharin and thiosaccharin as potential anticancer and antimicrobial agents

European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 12, С. 100205 - 100205

Опубликована: Авг. 23, 2024

Язык: Английский

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Recent Developments in Antimicrobial and Antiviral Agents Based on Natural/Synthetic Polymers and Dendrimers: Design and Therapeutic Applications

Macromolecular Chemistry and Physics, Год журнала: 2024, Номер 225(17)

Опубликована: Май 28, 2024

Abstract This review article explores the recent innovations in field of antimicrobial and antiviral macromolecules. With rising challenge antibiotic resistance, as well overuse antibiotics, there is a growing demand for efficient solutions to combat microbial viral infections. The development new effective agents highlighted. designed give comprehensive view literature focusing on few examples combating infections each section. A brief description naturally occurring organic‐based materials that exhibit and/or activities presented, polysaccharides, peptides, proteins. Synthetic are divided into subsections including polymers, dendrimers, nanomaterials. synthesis applications inorganic such polyphosphazenes polysiloxanes, tin‐, germanium‐ gallium‐based emphasized this review. Organometallic macromolecules also described, their examined. Overall, provides overview advancements design macromolecules, offering valuable insights potential biomedical research drug‐resistant microorganisms viruses.

Язык: Английский

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In Silico SwissADME Analysis of Antibacterial NHC–Silver Acetates and Halides Complexes

Applied Sciences, Год журнала: 2024, Номер 14(19), С. 8865 - 8865

Опубликована: Окт. 2, 2024

This study investigates the antibacterial N-heterocyclic carbene (NHC)–silver complexes using SwissADME platform, a web-based tool developed by Swiss Institute of Bioinformatics (SIB). NHCs, particularly their silver complexes, have gained significant interest in medicinal chemistry for potential as and anticancer agents. The effectiveness these is closely linked to structure, including factors like lipophilicity, which enhance ability penetrate bacterial cells sustain release active ions. provides computational estimates pharmacokinetic properties, absorption, distribution, metabolism, excretion (ADME) characteristics, well drug-likeness toxicity assessments. By evaluating parameters molecular weight, topological polar surface area, lipophilicity (LogP), water solubility, offers insights into drug-like compounds. inspired comprehensive review NHC–silver published from 2006 2023, identified superior structures with notable biological activity. primary aim determine whether exhibit distinct compared others, providing deeper understanding that influence efficacy aiding identification promising drug candidates. Finally, experimental stabilities exemplary were confronted absolute LUMO values derived DFT calculations.

Язык: Английский

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Antimicrobial Activity of Anionic Bis(N-Heterocyclic Carbene) Silver Complexes

Molecules, Год журнала: 2024, Номер 29(19), С. 4608 - 4608

Опубликована: Сен. 27, 2024

The antimicrobial properties of a series anionic bis(carbene) silver complexes Na

Язык: Английский

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Synthesis and Characterization of Gold(I) N-Heterocyclic Carbenes Complexes Bearing Methacrylate Moiety

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123514 - 123514

Опубликована: Янв. 1, 2025

Язык: Английский

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Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand

RSC Advances, Год журнала: 2025, Номер 15(3), С. 1782 - 1791

Опубликована: Янв. 1, 2025

The halide ligand of silver N-heterocyclic carbene complexes governs their antibacterial activity and mechanism action.

Язык: Английский

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Antibacterial Surfaces Prepared through Electropolymerization of N-Heterocyclic Carbene Complexes: A Pivotal Role of the Metal

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

N-Heterocyclic carbene (NHC) complexes are known to have antibacterial properties in solutions. However, these never been immobilized on solid supports prepare surfaces. Here, we tackled this lack and succeeded immobilizing NHC gold surfaces by electropolymerization. For this, synthesized a series of various different low-valent transition metals (M = Ag(I), Au(I), Rh(I), Ru(II), Cu(I)) bearing pyrrole function at the five-membered carbenic cycle. We measured against two Gram-negative (Escherichia coli Pseudomonas aeruginosa) Gram-positive bacteria (Staphylococcus aureus Listeria innocua) determining their minimum inhibitory concentration (MIC) values. All presented interesting that metal-dependent. The silver-NHC complex showed higher activity (MIC 16 μg·mL-1) than 32 was poorly efficient L. innocua. other metal-NHC were more bacteria, with MIC values range 4-16 μg·mL-1. These then electropolymerized substrates using function. Efficient incorporation species into polypyrrole (PPy) films confirmed X-ray photoelectron spectroscopy (XPS) measurements metal contents ranging from 0.8% (Cu) 12.3% (Ag). Scanning electron microscopy (SEM) profilometry ascertain homogeneity, structure, thickness depend metal. activities determined halo inhibition method. A very good match between those monomers Rh(I) found. complexes, metallic content too low obtain properties. cytotoxicity finally evaluated normal human dermal fibroblasts (NHDF). Our study reveals strong impact doping anions cell viability.

Язык: Английский

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Synthesis, characterization, and antibacterial properties of novel N-heterocyclic carbene (NHC) precursors and their silver complexes

Monatshefte für Chemie - Chemical Monthly, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Chirality in metal-based antimicrobial agents: a growing frontier in biomedical research

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Chirality matters! The search for eutomers in metalloantibiotics is necessary to increase efficacy the fight against antimicrobial resistance.

Язык: Английский

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Substituted (benzoimidazol-2-yl)Methanamines in Silver(I) Complexation in the Presence of Boron Cluster Anions

Journal of Cluster Science, Год журнала: 2025, Номер 36(3)

Опубликована: Апрель 21, 2025

Язык: Английский

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