Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 572, P. 122263 - 122263
Published: July 20, 2024
Language: Английский
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100205 - 100205
Published: Aug. 23, 2024
Language: Английский
Citations
6
Macromolecular Chemistry and Physics, Journal Year: 2024, Volume and Issue: 225(17)
Published: May 28, 2024
Abstract This review article explores the recent innovations in field of antimicrobial and antiviral macromolecules. With rising challenge antibiotic resistance, as well overuse antibiotics, there is a growing demand for efficient solutions to combat microbial viral infections. The development new effective agents highlighted. designed give comprehensive view literature focusing on few examples combating infections each section. A brief description naturally occurring organic‐based materials that exhibit and/or activities presented, polysaccharides, peptides, proteins. Synthetic are divided into subsections including polymers, dendrimers, nanomaterials. synthesis applications inorganic such polyphosphazenes polysiloxanes, tin‐, germanium‐ gallium‐based emphasized this review. Organometallic macromolecules also described, their examined. Overall, provides overview advancements design macromolecules, offering valuable insights potential biomedical research drug‐resistant microorganisms viruses.
Language: Английский
Citations
4
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8865 - 8865
Published: Oct. 2, 2024
This study investigates the antibacterial N-heterocyclic carbene (NHC)–silver complexes using SwissADME platform, a web-based tool developed by Swiss Institute of Bioinformatics (SIB). NHCs, particularly their silver complexes, have gained significant interest in medicinal chemistry for potential as and anticancer agents. The effectiveness these is closely linked to structure, including factors like lipophilicity, which enhance ability penetrate bacterial cells sustain release active ions. provides computational estimates pharmacokinetic properties, absorption, distribution, metabolism, excretion (ADME) characteristics, well drug-likeness toxicity assessments. By evaluating parameters molecular weight, topological polar surface area, lipophilicity (LogP), water solubility, offers insights into drug-like compounds. inspired comprehensive review NHC–silver published from 2006 2023, identified superior structures with notable biological activity. primary aim determine whether exhibit distinct compared others, providing deeper understanding that influence efficacy aiding identification promising drug candidates. Finally, experimental stabilities exemplary were confronted absolute LUMO values derived DFT calculations.
Language: Английский
Citations
4
Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4608 - 4608
Published: Sept. 27, 2024
The antimicrobial properties of a series anionic bis(carbene) silver complexes Na
Language: Английский
Citations
3
Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123514 - 123514
Published: Jan. 1, 2025
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(3), P. 1782 - 1791
Published: Jan. 1, 2025
The halide ligand of silver N-heterocyclic carbene complexes governs their antibacterial activity and mechanism action.
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
N-Heterocyclic carbene (NHC) complexes are known to have antibacterial properties in solutions. However, these never been immobilized on solid supports prepare surfaces. Here, we tackled this lack and succeeded immobilizing NHC gold surfaces by electropolymerization. For this, synthesized a series of various different low-valent transition metals (M = Ag(I), Au(I), Rh(I), Ru(II), Cu(I)) bearing pyrrole function at the five-membered carbenic cycle. We measured against two Gram-negative (Escherichia coli Pseudomonas aeruginosa) Gram-positive bacteria (Staphylococcus aureus Listeria innocua) determining their minimum inhibitory concentration (MIC) values. All presented interesting that metal-dependent. The silver-NHC complex showed higher activity (MIC 16 μg·mL-1) than 32 was poorly efficient L. innocua. other metal-NHC were more bacteria, with MIC values range 4-16 μg·mL-1. These then electropolymerized substrates using function. Efficient incorporation species into polypyrrole (PPy) films confirmed X-ray photoelectron spectroscopy (XPS) measurements metal contents ranging from 0.8% (Cu) 12.3% (Ag). Scanning electron microscopy (SEM) profilometry ascertain homogeneity, structure, thickness depend metal. activities determined halo inhibition method. A very good match between those monomers Rh(I) found. complexes, metallic content too low obtain properties. cytotoxicity finally evaluated normal human dermal fibroblasts (NHDF). Our study reveals strong impact doping anions cell viability.
Language: Английский
Citations
0
Monatshefte für Chemie - Chemical Monthly, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Chirality matters! The search for eutomers in metalloantibiotics is necessary to increase efficacy the fight against antimicrobial resistance.
Language: Английский
Citations
0
Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(3)
Published: April 21, 2025
Language: Английский
Citations
0