Journal of Material Science and Technology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Ultrasonics Sonochemistry, Год журнала: 2024, Номер 103, С. 106800 - 106800
Опубликована: Фев. 1, 2024
Fritillaria ussuriensis Maxim. (F.M.) has been widely used in both food and medication for more than 2000 years. In order to achieve its comprehensive utilization investigate the structural characterization biology activity, response surface methodology (RSM) was optimize ultrasound-assisted extraction conditions of F.M. polysaccharides. The optimal were ultrasonic power 174.2 W, ratio liquid material 40.7 mL/g time 82.0 min. addition, a neutral polysaccharide F-1 obtained, structure characterization, antioxidant immunological activity evaluated. properties characterized by UV, IR, GC–MS, NMR AFM. Monosaccharide composition (MW 18.11 kDa) rhamnose, arabinose, glucosamine hydrochloride, galactose, glucose which under 0.9: 3.8: 0.2: 2.9: 92.2. fractions mainly linked → 6)-α-D-Glcp-(1 with branch chain α-D-Glcp-(1 4)-α-D-Glcp-(1 4,6)-α-D-Glcp-(1 residues. Moreover, significant scavenging can clear hydroxyl radicals, superoxide anion, DPPH ABTS. showed that had an effect on macrophage phagocytic activity. And it increase release inflammatory factors including TNF-α, IL-1β IL-6. is novel great potential immunizer food, pharmaceutical cosmetic industries. study provide methodological basis research theoretical industrialized p4roduction practical application.
Язык: Английский
Процитировано
16
Free Radical Biology and Medicine, Год журнала: 2023, Номер 205, С. 25 - 46
Опубликована: Июнь 2, 2023
Язык: Английский
Процитировано
22
Life Sciences, Год журнала: 2023, Номер 331, С. 122060 - 122060
Опубликована: Авг. 29, 2023
Язык: Английский
Процитировано
22
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Янв. 3, 2024
Abstract Shiitake mushrooms are a fungal food that has been recorded in Chinese medicine to nourish the blood and qi. Lentinan (lLNT) is an active substance extracted from shiitake with powerful antioxidant, anti-inflammatory, anti-tumor functions. Inflammatory diseases cancers leading causes of death worldwide, posing serious threat human life health enormous challenges global systems. There still lack effective treatments for inflammatory cancer. LNT approved as adjunct chemotherapy China Japan. Studies have shown plays important role treatment well oncological diseases. Moreover, clinical experiments confirmed combined drugs significant effect improving prognosis patients, enhancing their immune function reducing side effects lung cancer, colorectal cancer gastric However, relevant mechanism action signaling pathway Therefore, this article reviews research tumor recent years.
Язык: Английский
Процитировано
12
Journal of Ethnopharmacology, Год журнала: 2024, Номер 324, С. 117794 - 117794
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
12
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129672 - 129672
Опубликована: Янв. 24, 2024
Язык: Английский
Процитировано
9
Inflammation Research, Год журнала: 2024, Номер 73(7), С. 1173 - 1184
Опубликована: Май 13, 2024
Abstract Objective and design To elucidate Sirt1’s role in gouty arthritis inflammation its potential mechanisms. Material Constructed murine models of conducted THP-1 cell experiments. Treatment 1 mg MSU crystals injected into mice ankle joints for a 72-h intervention. After 3-h pre-treatment with Sirt1-specific inhibitor (EX527) agonist (SRT2104), was induced 21 h using lipopolysaccharide (LPS) plus crystals. Methods We assessed severity through joint index, swelling, hematoxylin eosin (H&E) staining, measured CD68 mononuclear macrophages Sirt1 expression synovial tissue via immunohistochemistry. ELISA, NO assay, RT-qPCR, Flow cytometry, Western blot were utilized to examine macrophage inflammatory factors, polarization, reactive oxygen species(ROS), MAPK/NF-κB/AP-1 Nrf2/HO-1 pathways proteins. Results Significant edema, infiltration observed. elevated synovium. activation decreased M1 ROS generation. reduced p38/JNK phosphorylation, thereby inhibiting downstream NF-κB p65/AP-1 enhancing Nrf2/HO-1, thus suppressing inflammation. Conclusions alleviates polarization by the pathway activating pathway. Thus, may provide new therapeutic target arthritis.
Язык: Английский
Процитировано
8
Marine Drugs, Год журнала: 2025, Номер 23(1), С. 31 - 31
Опубликована: Янв. 9, 2025
Chitosan oligosaccharide (COS) is receiving increasing attention as a feed additive in animal production. COS has variety of biological functions, including anti-inflammatory and antioxidant activities. Mastitis major disease dairy cows that significant impact on welfare Hence, this research aimed to investigate the mechanism lipopolysaccharide (LPS)-stimulated inflammatory response oxidative stress bovine mammary epithelial cells (BMECs). In study, results demonstrated protected BMECs from induced by LPS restraining excessive production toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β). treatment also suppressed reactive oxygen species (ROS) restored enzyme activity under LPS-induced conditions. Furthermore, promote nuclear factor erythroid 2-related 2 (Nrf2) expression inhibit TLR4 levels p65 IκBα phosphorylation exposed LPS. summary, demonstrate protective depend TLR4/nuclear factor-κB (NF-κB) Nrf2 signaling pathways, indicating could serve natural agents for alleviating mastitis.
Язык: Английский
Процитировано
1
Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 13, 2025
Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, resistance to therapy. Pancreatic (PC) a highly aggressive malignancy of the gastrointestinal tract that has dismal 5-year survival rate less than 10%. Given essential function pancreas digestion, progression severely disrupts its function. Standard treatments PC such as surgical resection, chemotherapy, radiotherapy. However, these therapies often face significant challenges, including biochemical recurrence drug resistance. limitations, new therapeutic approaches are being developed target metabolism. Dysregulation cholesterol biosynthesis alterations fatty acids (FAs), palmitate, stearate, omega-3, omega-6, have been observed pancreatic cancer. These lipids serve energy sources, signaling molecules, components cell membranes. Their accumulation fosters an immunosuppressive microenvironment supports proliferation metastasis. Moreover, dysregulation within immune cells, particularly T impairs surveillance weakens body's defenses against Abnormal also contributes PC. Despite targeting may offer promising strategy. By enhancing peroxidation, induction ferroptosis—a form regulated death—could impair cells hinder disease progression.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130716 - 130716
Опубликована: Март 7, 2024
Язык: Английский
Процитировано
7