Engineered hydrogel platform for diabetic wound healing

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160379 - 160379

Опубликована: Фев. 1, 2025

Язык: Английский

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Bioactive Compounds Produced by Macromycetes for Application in the Pharmaceutical Sector: Patents and Products

Fermentation, Год журнала: 2024, Номер 10(6), С. 275 - 275

Опубликована: Май 23, 2024

It is widely known that mushrooms present several properties with applications in the medicinal and pharmaceutical sectors, including antimicrobial, immunomodulatory, antioxidant, hypotensive, neuroprotective, anti-inflammatory activities. This article aims to review examples of bioactive metabolites responsible for those activities, such as polysaccharides, phenols polyphenols, terpenes, peptides, alkaloids, steroids, which are produced by relevant mushroom species. also discusses their production through solid-state fermentation submerged fermentation, well processes obtention extracts considerations on stability aiming industrial applications. In addition, examines patent landscape surrounding mushroom-derived bioactives, shedding light intellectual property history innovations driving this field forward. Examples recently deposited patents highlighted, main depositors. China United States major depositor countries (52% 35% patents, respectively), principal compounds polysaccharides alkaloids. The provides insights into current market landscape, showcasing products available consumers. From dietary supplements skincare formulations, offerings reflect growing interest harnessing health benefits bioactives.

Язык: Английский

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Advances in the development of medical dressings for the treatment of diabetic foot wounds

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155575 - 155575

Опубликована: Сен. 7, 2024

Язык: Английский

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Photo-Crosslinking Hydrogel Based on Porcine Small Intestinal Submucosa Decellularized Matrix/Fish Collagen/GelMA for Culturing Small Intestinal Organoids and Repairing Intestinal Defects

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 663 - 663

Опубликована: Янв. 14, 2025

Organoid technology, as an innovative approach in biomedicine, exhibits promising prospects disease modeling, pharmaceutical screening, regenerative medicine, and oncology research. However, the use of tumor-derived Matrigel primary method for culturing organoids has significantly impeded clinical translation organoid technology due to concerns about potential risks, batch-to-batch instability, high costs. To address these challenges, this study innovatively introduced a photo-crosslinkable hydrogel made from porcine small intestinal submucosa decellularized matrix (SIS), fish collagen (FC), methacrylate gelatin (GelMA). The cost-effective demonstrated excellent biocompatibility, tunable mechanical properties, rapid gelation low immunogenicity. Importantly, proliferation differentiation capacities cultured were comparable those Matrigel, with no significant disparity observed. Furthermore, after one week transplantation nude mice, hydrogel-organoid complex exhibited sustained structural functional stability while preserving characteristics organoids. Our also effective FC/SIS/GelMA accelerating repair process defects, reducing area scar formation, promoting regeneration both villi smooth muscle tissue. In summary, presents novel protocol organoids, offering implications future applications serving experimental foundation development tissue-engineered intestines based on

Язык: Английский

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Tannic Acid Post-Treatment of Hydrogels Based on Bletilla Striata Polysaccharide and Hyaluronic Acid for Promotion of Diabetic Wound Healing Via Antibacterial and Pro-Angiogenesis

Опубликована: Янв. 1, 2025

Язык: Английский

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Polydopamine-modified hydroxyapatite and manganese tetroxide nanozyme incorporated gelatin methacryloyl hydrogel: A multifunctional platform for anti-bacteria, immunomodulation, angiogenesis, and enhanced regeneration in infected wounds

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141834 - 141834

Опубликована: Март 1, 2025

Язык: Английский

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Tracheal regeneration and mesenchymal stem cell augmenting potential of natural polyphenol-loaded gelatinmethacryloyl bioadhesive

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132506 - 132506

Опубликована: Май 20, 2024

Язык: Английский

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