physica status solidi (a),
Год журнала:
2024,
Номер
221(5)
Опубликована: Янв. 26, 2024
The
complex
of
sodium
carboxymethyl
cellulose
(CMC)
and
chitosan
(CH)
in
aqueous
solution
can
be
used
for
biomedical
applications
is
very
beneficial
tissue
engineering,
drug
delivery,
disease
treatment.
This
article
presents
elaboration
properties
the
two
polysaccharides
with
opposite
charges
CMC/CH
solutions.
electrical
conductivity
under
influence
increasing
concentrations
mixtures
from
(0.5
to
10)
g
l
−1
temperatures
288.15
318.15
K
investigated.
reduced
conductivities,
,
energy
activation
Gibbs
free
activations
parameters
enthalpy
()
entropy
are
estimated.
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
To
improve
the
therapy
of
chemotherapy
for
cancer
treatment,
hydrogels
sodium
carboxymethyl
cellulose
(CMC)/copper-doped
Prussian
blue
(CDPB)
are
synthesized
controlled
delivery
cytarabine
(Cyt).
CMC
is
connected
to
3-aminophenylboronic
acid
(PBA)
and
dopamine
(DA),
respectively,
by
amidation
reactions,
obtained
CMC-PBA
CMC-DA
cross-linked
through
boronate
affinity
encapsulation
CDPB
Cyt.
The
resultant
CMC/CDPB/Cyt
can,
respond
pH
H2O2,
thus,
pH-
H2O2-responsive
Cyt
from
successfully
achieved.
More
importantly,
overexpressed
H2O2
in
cells
can
be
converted
hydroxyl
radicals
(•OH)
Fenton-like
generated
•OH
participate
chemodynamic
(CDT)
cancers.
Due
combination
treatment
CDT,
enhanced
anticancer
effects
using
human
acute
promyelocytic
leukemia
(HL-60)
cell
lines
as
model
target.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 31, 2025
Abstract
Background
Breast
cancer
remains
one
of
the
leading
causes
death
among
women
globally,
with
traditional
therapies
often
limited
by
challenges
such
as
drug
resistance
and
significant
side
effects.
Combination
therapies,
coupled
nanotechnology-based
co-delivery
systems,
offer
enhanced
efficacy
targeting
multiple
pathways
in
progression.
In
this
study,
we
developed
an
injectable,
stimuli-responsive
nanosystem
using
a
chitosan
hydrogel
embedded
mesoporous
silica
nanoparticles
for
co-administration
5-fluorouracil
everolimus.
This
approach
aims
to
optimize
controlled
release,
enhance
synergistic
anticancer
effect,
overcome
associated
co-loading
different
therapeutic
agents.
Methods
Various
techniques
were
employed
characterize
hydrogel.
Cell
uptake,
apoptosis,
proliferation
4T1
breast
cells
evaluated
flow
cytometry
Resazurin
assay,
respectively.
The
Balb/C
mice
model
cancer,
which
received
therapeutical
nanoplatforms
subcutaneously
near
tumoral
region
was
used
examine
tumor
size
lung
metastases.
Results
results
revealed
that
had
suitable
loading
capacity
high
cellular
uptake.
release
pH-sensitive
synergistic.
By
incorporating
into
hydrogel,
cell
rate
apoptosis
increased
significantly,
due
effects
co-delivered
drugs.
Additionally,
combination
treatment
groups
showed
reduction
metastasis
compared
monotherapy
control
groups.
Conclusions
These
findings
underscore
potential
nanocomposite
develop
novel
system
outcomes,
reduce
effects,
provide
promising
new
strategy
future
treatments.
ACS Omega,
Год журнала:
2023,
Номер
8(43), С. 40494 - 40507
Опубликована: Окт. 20, 2023
Stearoyl
chitosan
(SC),
derived
from
the
acylation
of
chitosan,
contributes
to
efficiency
drug
delivery
systems
because
its
structure,
which
accommodates
in
a
particle.
Nonetheless,
role
chemotherapy
has
been
largely
unexplored.
The
present
study
involves
synthesis
stearoyl
through
reaction
depolymerized
with
chloride
under
mild
conditions.
resulting
compound
was
subjected
structural
analysis
utilizing
Fourier-transform
infrared
(FTIR)
spectroscopy,
1H
NMR,
and
X-ray
diffraction
(XRD)
spectroscopy.
dispersion
SC
molecules
phosphate-buffered
saline
(PBS)
forms
nanoparticles.
best
solution
achieved
at
1:60
chitosan-to-stearoyl
weight
ratio.
Three
antimetabolite
drugs,
methotrexate,
pemetrexed,
raltitrexed,
were
selected
examine
loading
efficacy
SC.
Pemetrexed
had
highest
drug-loading
value
36.8%
among
three
antimetabolites
incorporated
into
SC,
along
an
encapsulation
85.1%.
size
loaded
ranged
225
369
nm,
their
spherical
form
verified
via
transmission
electron
microscope.
vitro
release
showed
that
demonstrated
controlled
release,
suggesting
nanoparticles
have
significant
promise
as
strategy
for
chemotherapy.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(9), С. 10016 - 10028
Опубликована: Апрель 18, 2024
For
most
degradable
nanocarriers,
precisely
controlled
delivery
remains
a
challenge
because
the
drug
release
is
fast
in
neutral
buffer
solution.
The
unfavorable
leakage
could
lead
to
serious
toxicity.
Thus,
it
important
realize
precise
for
nanocarriers
with
biodegradability
but
excellent
stability
physiological
environment.
Here,
biodegradable
pH/redox-responsive
system,
quercetin
(Que)-loaded
and
poly(ethylene
glycol)
(PEG)-modified
manganese
(Mn)-containing
mesoporous
silica
nanoparticles
(MSN),
designated
as
PEG@MSN(Mn)@Que,
was
built
cancer
therapy.
Nanoparticles
present
rough
nanoscale
spherical
morphology
an
average
size
of
107.2
nm
ordered
structure.
Quercetin
has
been
successfully
loaded
efficiency
46.47%
rate
48.64%.
Mn–O
bonds
were
formed
by
doping
Mn
MSN
framework
at
molecular
level,
Mn-doping
amount
36.59%.
cleavage
promotes
specific
biodegradation
PEG@MSN(Mn)@Que
Que
tumor
microenvironment.
Especially,
degradation
behaviors
showed
conditions
5
days,
very
low
(only
5.65%
released),
achieving
delivery.
A
high
antitumor
effect
simultaneously
achieved
anticancer
mediated
biocompatibility
systematically
demonstrated
vitro
vivo.
This
work
provides
feasible
way
reduce
side
effects
caused
leakage,
improving
effect.
