Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1829 - 1829

Опубликована: Июнь 26, 2023

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.

Язык: Английский

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Mupirocin loaded core-shell pluronic-pectin-keratin nanofibers improve human keratinocytes behavior, angiogenic activity and wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126700 - 126700

Опубликована: Сен. 4, 2023

Язык: Английский

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A double-layer cellulose/pectin-soy protein isolate-pomegranate peel extract micro/nanofiber dressing for acceleration of wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 255, С. 128198 - 128198

Опубликована: Ноя. 20, 2023

Язык: Английский

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Biomimetic VEGF-loaded bilayer scaffold fabricated by 3D printing and electrospinning techniques for skin regeneration

Materials & Design, Год журнала: 2024, Номер 238, С. 112714 - 112714

Опубликована: Янв. 30, 2024

Among the fabrication methods, 3D printing due to excellent accuracy, reproducibility and customizability as well electrospinning ability mimic extracellular matrix structure have received many attentions. Herein, we used combination of both mentioned techniques produce a biomimetic bilayer scaffold for skin tissue regeneration. The upper layer was made printed dextran-vascular endothelial growth factor (Dex-VEGF) stimulate angiogenesis cell migration, bottom electrospun gelatin-keratin (Gel-Kr) nanofibers induce attachment. tensile strength elastic modulus scaffolds were measured in range 0.26 – 0.33 MPa 5.8 7.2 MPa, respectively. investigations revealed that release VEGF lasted up 7 days. VEGF-loaded demonstrated best cellular behaviour. Chicken chorioallantoic membrane (CAM) assay confirmed highest angiogenic potential presence scaffold. Also, based on vivo animal studies histopathological immunohistochemical examinations, wound healing rate related within 14 obtained promising results introduce prepared perfect construct accelerate healing.

Язык: Английский

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Core-shell nanofibers containing L-arginine stimulates angiogenesis and full thickness dermal wound repair

International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123931 - 123931

Опубликована: Фев. 20, 2024

Язык: Английский

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Platelet rich fibrin and simvastatin-loaded pectin-based 3D printed-electrospun bilayer scaffold for skin tissue regeneration

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130954 - 130954

Опубликована: Март 16, 2024

Язык: Английский

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Exploring nanobioceramics in wound healing as effective and economical alternatives

Heliyon, Год журнала: 2024, Номер 10(19), С. e38497 - e38497

Опубликована: Сен. 26, 2024

Язык: Английский

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An antibacterial Multi-Layered scaffold fabricated by 3D printing and electrospinning methodologies for skin tissue regeneration

International Journal of Pharmaceutics, Год журнала: 2023, Номер 645, С. 123357 - 123357

Опубликована: Авг. 28, 2023

Язык: Английский

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Asymmetric tri-layer sponge-nanofiber wound dressing containing insulin-like growth factor-1 and multi-walled carbon nanotubes for acceleration of full-thickness wound healing

Biomaterials Advances, Год журнала: 2023, Номер 151, С. 213468 - 213468

Опубликована: Май 18, 2023

Язык: Английский

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Keratin- and VEGF-Incorporated Honey-Based Sponge–Nanofiber Dressing: An Ideal Construct for Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(48), С. 55276 - 55286

Опубликована: Ноя. 22, 2023

To overcome the drawbacks of single-layered wound dressings, bilayer dressings are now introduced as an alternative to achieve effective and long-term treatment. Here, a dressing composed electrospun nanofibers in bottom layer (BL) sponge structure top (TL) is presented. Hydrophilic poly(acrylic acid) (PAAc)-honey (Hny) with interconnected pores 76.04 μm was prepared TL keratin (Kr), Hny, vascular endothelial growth factor (VEGF) were BL. VEGF indicates gradual release over 7 days, promoting angiogenesis, proven by chick chorioallantoic membrane assay vivo tissue histomorphology observation. Additionally, fabricated material indicated satisfactory tensile profile, cytocompatibility for human keratinocyte cells, ability promote cell attachment migration. The animal model demonstrated that full-thickness healed faster when it covered PAAc-Hny/Hny-Kr-VEGF than other groups. blood vessel formation, collagen synthetization, epidermal generation also confirmed, which have efficient healing acceleration wounds treated synthesized dressings. Our findings can be promising functional dressing.

Язык: Английский

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