Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
ABSTRACT
Recent
advancements
in
hydrogel‐based
flexible
materials
have
revolutionized
wound
healing
and
monitoring
strategies.
These
offer
promising
solutions
for
medical
treatment
real‐time
diagnostics.
Their
rich
water
content,
biocompatibility,
tunable
properties
closely
mimic
the
natural
extracellular
matrix,
supporting
regeneration.
Unlike
traditional
materials,
systems
address
critical
issues
such
as
material
stability
toxicity
while
integrating
advanced
devices.
This
review
highlights
latest
innovations
materials.
It
focuses
on
flexibility,
potential
integration
with
smart
systems.
The
covers
design
principles
fabrication
techniques
nanofibers,
elastomers,
conducting
polymers.
also
discusses
development
of
electronic
skin
innovative
dressings.
In
addition,
explains
how
sensing
capabilities,
stimuli‐responsive
functions,
antibacterial
agents
are
incorporated
into
these
Finally,
article
examines
challenges
future
directions
field.
emphasizes
transformative
multifunctional
improving
continuous
monitoring.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
238, P. 112714 - 112714
Published: Jan. 30, 2024
Among
the
fabrication
methods,
3D
printing
due
to
excellent
accuracy,
reproducibility
and
customizability
as
well
electrospinning
ability
mimic
extracellular
matrix
structure
have
received
many
attentions.
Herein,
we
used
combination
of
both
mentioned
techniques
produce
a
biomimetic
bilayer
scaffold
for
skin
tissue
regeneration.
The
upper
layer
was
made
printed
dextran-vascular
endothelial
growth
factor
(Dex-VEGF)
stimulate
angiogenesis
cell
migration,
bottom
electrospun
gelatin-keratin
(Gel-Kr)
nanofibers
induce
attachment.
tensile
strength
elastic
modulus
scaffolds
were
measured
in
range
0.26
–
0.33
MPa
5.8
7.2
MPa,
respectively.
investigations
revealed
that
release
VEGF
lasted
up
7
days.
VEGF-loaded
demonstrated
best
cellular
behaviour.
Chicken
chorioallantoic
membrane
(CAM)
assay
confirmed
highest
angiogenic
potential
presence
scaffold.
Also,
based
on
vivo
animal
studies
histopathological
immunohistochemical
examinations,
wound
healing
rate
related
within
14
obtained
promising
results
introduce
prepared
perfect
construct
accelerate
healing.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(48), P. 55276 - 55286
Published: Nov. 22, 2023
To
overcome
the
drawbacks
of
single-layered
wound
dressings,
bilayer
dressings
are
now
introduced
as
an
alternative
to
achieve
effective
and
long-term
treatment.
Here,
a
dressing
composed
electrospun
nanofibers
in
bottom
layer
(BL)
sponge
structure
top
(TL)
is
presented.
Hydrophilic
poly(acrylic
acid)
(PAAc)-honey
(Hny)
with
interconnected
pores
76.04
μm
was
prepared
TL
keratin
(Kr),
Hny,
vascular
endothelial
growth
factor
(VEGF)
were
BL.
VEGF
indicates
gradual
release
over
7
days,
promoting
angiogenesis,
proven
by
chick
chorioallantoic
membrane
assay
vivo
tissue
histomorphology
observation.
Additionally,
fabricated
material
indicated
satisfactory
tensile
profile,
cytocompatibility
for
human
keratinocyte
cells,
ability
promote
cell
attachment
migration.
The
animal
model
demonstrated
that
full-thickness
healed
faster
when
it
covered
PAAc-Hny/Hny-Kr-VEGF
than
other
groups.
blood
vessel
formation,
collagen
synthetization,
epidermal
generation
also
confirmed,
which
have
efficient
healing
acceleration
wounds
treated
synthesized
dressings.
Our
findings
can
be
promising
functional
dressing.
