The International Journal of Lower Extremity Wounds,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 15, 2024
Nanohydrogel
wound
healing
refers
to
the
use
of
nanotechnology-based
hydrogel
materials
promote
wounds.
Hydrogel
dressings
are
made
up
a
three-dimensional
network
hydrophilic
polymers
that
can
absorb
and
retain
large
amounts
water
or
other
fluids.
Nanohydrogels
take
this
concept
further
by
incorporating
nanoscale
particles
structures
into
matrix.
These
nanoparticles
be
various
materials,
such
as
silver,
zinc
oxide,
derived
from
natural
substances
like
chitosan.
The
inclusion
provide
additional
properties
benefits
dressings.
designed
release
bioactive
substances,
growth
factors
drugs,
in
controlled
manner.
This
allows
for
targeted
delivery
therapeutics
site,
promoting
reducing
inflammation.
Nanoparticles
reinforce
structure
hydrogels,
improving
their
mechanical
strength
stability.
often
incorporate
antimicrobial
nanoparticles,
silver
oxide.
have
shown
effective
activity
against
wide
range
bacteria,
fungi,
pathogens.
By
them
dressings,
nanohydrogels
help
prevent
reduce
risk
infection
encapsulate
factors,
peptides,
sustained
therapeutic
agents
promotes
facilitating
cell
proliferation,
inflammation,
supporting
tissue
regeneration.
unique
nanohydrogels,
including
ability
maintain
moist
environment
deliver
agents,
accelerate
process.
creating
an
optimal
repair,
faster
more
efficient
Abstract
Collagen
with
a
multi-hierarchical
architecture
exhibits
powerful
biological
performance,
thus
being
developed
in
biomedical
applications
as
processing
building
block.
The
isolated
collagen
after
extraction
from
tissues
can
be
processed
into
various
forms
such
fibrils,
scaffolds,
membranes,
microspheres,
hydrogels,
and
sponges
for
further
use
specific
applications.
This
review
briefly
discusses
the
structure,
performances,
extraction,
approaches
of
natural
biomaterial.
including
dissolution,
self-assembly,
cross-linking,
electrospinning,
is
discussed
to
show
more
feasibility
composite
biomaterials.
Further
emphasis
directed
towards
drug
gene
delivery,
well
tissue
repair
involving
bone,
cartilage,
vascular,
corneal,
along
wound
healing.
Additionally,
there
focus
on
development
flexible
sensors
electronic
skins
(e-skins).
Furthermore,
potential
challenges
perspectives
collagen-based
biomaterials
are
proposed.
In
short,
expected
facilitate
sustainable
next
generation
advanced
biomaterial
Graphical
Materials & Design,
Год журнала:
2023,
Номер
237, С. 112623 - 112623
Опубликована: Дек. 30, 2023
The
treatment
of
tenacious
diabetic
wounds
still
remains
an
enormous
challenge
in
clinics,
originated
from
the
complicated
pathological
microenvironment
wound
sites.
Therefore,
it's
urgently
required
to
develop
one
type
innovative
dressing
patch
with
appropriate
microstructure
and
multifunctions
regulate
promote
regeneration
wounds.
In
this
study,
novel
gelatin
(Gel)/poly
(L-lactic
acid)
(PLLA)
nanofibrous
yarns
loading
or
without
Salvia
miltiorrhiza
Bunge-Radix
Puerariae
herbal
compound
(SRHC)
are
fabricated
by
using
our
modified
electrospinning
strategy,
which
further
interlaced
into
woven
fabrics
respectively,
serving
as
biofunctional
patches
for
potential
application.
actual
photographs
SEM
images
confirm
that
all
different
textiles
SRHC
exhibited
a
uniform
interwoven
structure
warp
weft,
internal
nanofibers
present
bead-free
morphology
uniaxially
oriented
along
longitudinal
axis
yarns.
Moreover,
demonstrated
possess
strong
mechanical
properties
great
surface
wettability.
vitro
cell
characterization
shows
addition
can
significantly
attachment
proliferation
human
dermal
fibroblasts
(HDFs),
also
dramatically
inhibit
secretion
levels
proinflammatory
factors
M1
macrophages.
vivo
mouse
full-thickness
skin
model
experiments
reveal
as-developed
SRHC-loaded
Gel/PLLA
textile
best
performances
referring
short
healing
time
(100
%
closure
after
18
days
treatment)
high-quality
(i.e.,
enhance
collagen
deposition,
improve
re-epithelialization
neovascularization,
increase
hair
follicles),
assuredly
finds
interests
hard-to-heal
Polymers,
Год журнала:
2024,
Номер
16(10), С. 1351 - 1351
Опубликована: Май 10, 2024
Chitosan,
a
versatile
biopolymer
derived
from
chitin,
has
garnered
significant
attention
in
various
biomedical
applications
due
to
its
unique
properties,
such
as
biocompatibility,
biodegradability,
and
mucoadhesiveness.
This
review
provides
an
overview
of
the
diverse
chitosan
derivatives
antibacterial,
anticancer,
wound
healing,
tissue
engineering
fields.
In
antibacterial
applications,
exhibits
potent
antimicrobial
properties
by
disrupting
microbial
membranes
DNA,
making
it
promising
natural
preservative
agent
against
bacterial
infections.
Its
role
cancer
therapy
involves
development
chitosan-based
nanocarriers
for
targeted
drug
delivery,
enhancing
therapeutic
efficacy
while
minimising
side
effects.
Chitosan
also
plays
crucial
healing
promoting
cell
proliferation,
angiogenesis,
regulating
inflammatory
responses.
Additionally,
serves
multifunctional
scaffold
engineering,
facilitating
regeneration
tissues
cartilage,
bone,
neural
adhesion
proliferation.
The
extensive
range
pharmaceutical
sciences
is
not
only
highlighted
comprehensive
scope
this
review,
but
establishes
fundamental
component
forthcoming
research
biomedicine.
JCIS Open,
Год журнала:
2023,
Номер
12, С. 100095 - 100095
Опубликована: Сен. 29, 2023
The
lung
is
an
attractive
target
for
drug
delivery
because
of
the
ease
non-invasive
administration
via
inhalation,
bypassing
metabolism
in
liver,
direct
to
respiratory
system
treatment
diseases,
and
a
large
surface
area
absorption.
Nanocarrier
systems
offer
several
benefits
pulmonary
delivery,
including
uniform
distribution
among
alveoli,
improved
solubility,
sustained
release,
which
reduces
dosing
frequency
enhances
patient
compliance,
potential
cell
internalization.
Nanomedicine
also
being
utilized
combat
emerging
infectious
illnesses
like
SARS-CoV,
SARS-CoV-2,
MERS-CoV,
influenza
A/H1N1.
This
review
gives
quick
rundown
diseases
caused
by
agents
such
as
bacterial,
viral,
biological
roadblocks
that
prevent
effective
recalcitrant
tract
infections.
We
emphasized
summarized
recent
efforts
these
infections
using
novel
inhaled
formulation-mediated
strategies
nanocarriers
liposomes,
polymeric
nanoparticles,
SLNs.
In
addition,
we
reviewed
latest
findings
advancements
regarding
development
inhalable
formulations
circumvent
barriers
boost
bioavailability.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Июль 22, 2024
Abstract
Due
to
repeated
microbial
infection,
persistent
inflammation,
excessive
oxidative
stress,
and
cell
dysfunction,
chronic
wounds
are
difficult
heal,
posing
a
serious
threat
public
health.
Therefore,
developing
multifunctional
wound
dressings
that
can
regulate
the
complex
microenvironment
of
enhance
cellular
function
holds
great
significance.
Recently,
chitosan
has
emerged
as
promising
biopolymer
for
healing
due
its
excellent
biocompatibility,
biodegradability,
versatile
bioactivity.
The
aim
this
review
is
provide
comprehensive
understanding
mechanisms
delayed
discuss
healing–promoting
properties
derivatives,
such
good
antibacterial
activity,
hemostatic
capacity,
ability
promote
tissue
regeneration.
On
basis,
potential
applications
chitosan‐based
hydrogels
summarized
in
healing,
including
providing
suitable
microenvironment,
eliminating
bacterial
infections,
promoting
hemostasis,
inhibiting
alleviating
In
addition,
concerns
perspectives
clinical
application
also
discussed.
