Bioengineering,
Год журнала:
2024,
Номер
11(12), С. 1278 - 1278
Опубликована: Дек. 16, 2024
Antibiotic
therapy
has
been
a
common
method
for
treating
bacterial
infections
over
the
past
century,
but
with
rise
in
resistance
caused
by
antibiotic
abuse,
better
control
and
more
rational
use
of
antibiotics
have
increasingly
demanded.
At
same
time,
journey
to
explore
alternatives
therapies
also
undertaken.
Chitosan
its
derivatives,
materials
good
biocompatibility,
biodegradability,
excellent
antibacterial
properties,
garnered
significant
attention,
studies
on
chitosan
derivatives
conducted
recent
years.
In
this
work,
we
aim
elucidate
biological
properties
track
their
clinical
applications,
as
well
propose
issues
that
need
be
addressed
possible
solutions
further
future
development
application.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 13, 2024
Abstract
The
eye,
a
complex
organ
isolated
from
the
systemic
circulation,
presents
significant
drug
delivery
challenges
owing
to
its
protective
mechanisms,
such
as
blood-retinal
barrier
and
corneal
impermeability.
Conventional
administration
methods
often
fail
sustain
therapeutic
levels
may
compromise
patient
safety
compliance.
Polysaccharide-based
microneedles
(PSMNs)
have
emerged
transformative
solution
for
ophthalmic
delivery.
However,
comprehensive
review
of
PSMNs
in
ophthalmology
has
not
been
published
date.
In
this
review,
we
critically
examine
synergy
between
polysaccharide
chemistry
microneedle
technology
enhancing
ocular
We
provide
thorough
analysis
PSMNs,
summarizing
design
principles,
fabrication
processes,
addressed
during
fabrication,
including
improving
comfort
also
describe
recent
advances
performance
various
both
research
clinical
scenarios.
Finally,
current
regulatory
frameworks
market
barriers
that
are
relevant
commercial
advancement
final
perspective
on
area.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25604 - e25604
Опубликована: Фев. 1, 2024
Gentamicin
(GEN),
a
widely
used
broad-spectrum
antibiotic,
faces
challenges
amid
the
global
emergency
of
antimicrobial
resistance.
This
study
aimed
to
explore
synergistic
effects
zinc
oxide
nanoparticles
(ZnO
NPs)
in
combination
with
GEN
on
bactericidal
activity
against
various
bacterial
strains.
Results
showed
ZnO
NPs
MICs
ranging
from
0.002
1.5
μg/mL,
while
precursor
salt
displayed
MIC
range
48.75–1560
μg/mL.
Chitosan
(CS)-capped
exhibited
even
lower
than
their
uncapped
counterparts,
CS-capped
synthesized
demonstrating
lowest
values.
Minimal
concentrations
(MBC)
aligned
trends.
Combinations
and
proved
highly
effective,
inhibiting
growth
at
significantly
or
alone.
phenomenon
may
be
attributed
conformation
CS
NPs'
surface,
enhancing
positive
particle
surface
charge.
possibly
facilitates
more
effective
interaction
between
microorganisms,
leading
increased
accumulation
within
cells
an
overproduction
reactive
oxygen
species
(ROS).
It's
crucial
note
that,
this
did
not
specifically
involve
resistant
strains,
its
primary
focus
remains
overall
gentamicin.
The
research
aims
contribute
addressing
challenge
resistance,
recognizing
urgent
need
for
strategies
combat
critical
issue.
findings,
particularly
observed
synergy
GEN,
hold
significant
implications
repositioning
first-line
antibiotic
GEN.
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 200 - 200
Опубликована: Янв. 15, 2025
Background/objectives:
The
aim
of
the
study
was
to
create
a
nanofiber
insert
incorporating
Timolol
(TIM)
and
Dorzolamide
(DOR),
targeting
management
glaucoma.
This
condition
encompasses
variety
chronic,
advancing
ocular
disorders
typically
associated
with
elevated
intraocular
pressure
(IOP).
Methods:
made
Eudragite
RL100
(EUD)
polymer,
biocompatible
material
high
bioavailability,
using
electrospinning
method.
inserts
were
studied
for
morphology,
drug–polymer
interaction,
physicochemical
properties,
in
vitro
drug-release
study.
pharmacokinetic
properties
fibers
examined
alongside
consideration
irritation
rabbit
model
cell
compatibility.
Results:
results
test
showed
retention
controlled
release
both
DOR/TIM
over
80
h.
Morphological
examination
demonstrated
uniform
nanofibers
mean
diameters
<
465
nm.
compatibility
percentage
survival,
none
formulations
irritated
rabbit’s
eye.
Area
Under
Curve
(AUC0-72)
DOR
TIM
EDT
approximately
3216.63
±
63.25
µg·h/mL
2598.89
46.65
µg·h/mL,
respectively,
Mean
Residence
Times
(MRTs)
21.6
0.19
h
16.29
6.44
Conclusions:
Based
on
results,
dual
drug-loaded
preservative-free
system
can
potentially
be
suitable
alternative
eye
drops
used
reduce
fluctuation
dose
frequency.
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(2)
Опубликована: Фев. 1, 2025
ABSTRACT
The
search
for
novel
drug
delivery
systems
has
generated
great
interest
in
biopolymer‐based
carriers.
Among
these,
carboxymethyl
guar
gum
(CMGG)
been
shown
to
be
promising.
CMGG
is
a
chemically
modified
derivative
of
that
synthesized
by
carboxymethylation
with
monochloroacetic
acid
and
sodium
hydroxide
under
optimized
conditions.
This
improves
the
physicochemical
properties
polysaccharide,
which
are
enhanced
hydrophilicity,
viscosity,
swelling
behavior
compared
unmodified
Guar
gum.
review
focuses
on
wide
applications
systems,
thus
underlining
its
versatility
as
an
excipient
based
unique
properties.
Key
features
such
pseudoplasticity
allow
effective
drugs
controlled‐release
systems.
Advanced
characterization
techniques,
like
Fourier
Transform
Infrared
Spectroscopy
Nuclear
Magnetic
Resonance
(NMR)
spectroscopy,
confirm
structural
changes
due
carboxymethylation;
further
aspects
emphasized
rheological
studies,
highlight
applicability
pharmaceutical
fields.
biocompatibility
biodegradability
add
advantages,
offering
safety
compatibility
environment
therapeutic
applications.
capacity
enclose
hydrophilic
well
control
release
profiles
shows
promise
efficacy
enhancement
patient
safety.
puts
forward
represents
excellent
means
development
enhancing
outcomes.
