Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 10, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
caused
by
insulin
resistance
(IR)
and
insufficient
secretion.
Its
characteristic
pathophysiological
processes
involve
the
interaction
of
multiple
mechanisms.
In
recent
years,
globally,
prevalence
T2DM
has
shown
sharp
rise
due
to
profound
changes
in
socio-economic
structure,
persistent
influence
environmental
factors,
complex
role
genetic
background.
It
worth
noting
that
most
patients
show
significant
IR,
which
further
exacerbates
difficulty
progression
prevention.
process
extensively
exploring
pathogenesis
T2DM,
dynamic
equilibrium
gut
microbes
its
diverse
activities
have
increasingly
emphasized
central
T2DM.
Bile
acids
(BAs)
metabolism,
as
crucial
link
between
development
not
only
precisely
regulates
lipid
absorption
metabolism
but
also
profoundly
influences
glucose
homeostasis
energy
balance
through
intricate
signaling
pathways,
thus
playing
pivotal
IR
This
review
aims
delve
into
specific
mechanism
BAs
contribute
especially
emphasizing
how
mediate
transformation
based
on
current
traditional
Chinese
medicine
research.
Ultimately,
it
seeks
offer
new
insights
prevention
treatment
Diet,
genetics,
environment
intricately
sculpt
microbiota
influencing
T2DM-IR.
The
research
illuminated
impact
single
herbal
medicine,
TCM
formulae,
external
therapeutic
methods
such
electroacupuncture
pool
perturbations
structure.
affects
well
sensitivity.
Additionally,
pathways
including
BA-FXR-SHP,
BA-FXR-FGFR15/19,
BA-FXR-NLRP3,
BA-TGR5-GLP-1,
BAs-TGR5/FXR
been
identified
significantly
alter
blood
levels
improve
IR.
These
findings
novel
approaches
for
enhancing
managing
disorders
among
with
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 15, 2023
Bile
acids
are
the
main
component
of
animal
bile
and
directly
involved
in
metabolic
process
lipids
vivo.
Taurochenodeoxycholic
acid
(TCDCA)
is
primary
biologically
active
substance
has
biological
functions
such
as
antioxidant,
antipyretic,
anti-inflammatory,
analgesic
activities
improves
immunity.
In
present
study,
we
assessed
impact
TCDCA
on
hyperlipidemia
development
mouse
models.
Mice
were
fed
a
high-fat
diet
(HFD)
to
induce
orally
administered
different
doses
for
30
days.
Then,
indicators
triglyceride
(TG),
total
cholesterol
(TC),
low-density
lipoprotein
(LDL-C),
high-density
(HDL-C)
mice
detected.
Using
HE
ORO
staining
techniques,
morphology
mice's
liver
tissue
was
Based
metabolomic
lipidomic
analyses,
determined
mechanism
treating
hyperlipidemia.
The
results
showed
that
had
significant
ameliorating
effect
dietary
addition,
it
exerted
therapeutic
effects
through
glycerophospholipid
metabolism.
Drug Design Development and Therapy,
Год журнала:
2023,
Номер
Volume 17, С. 3803 - 3831
Опубликована: Дек. 1, 2023
Abstract:
Dysregulation
of
the
gut
microbial
ecosystem
(GME)
(eg,
alterations
in
microbiota,
gut-derived
metabolites,
and
barrier)
may
contribute
to
onset
progression
extra-intestinal
diseases.
Previous
studies
have
found
that
Traditional
Chinese
Medicine
herbs
(TCMs)
play
an
important
role
manipulating
GME,
but
a
prominent
obstacle
current
TCM
research
is
causal
relationship
between
GME
disease
amelioration.
Encouragingly,
co-housing
fecal
microbiota
transplantation
(FMT)
provide
evidence-based
support
for
TCMs
treat
diseases
by
targeting
GME.
In
this
review,
we
documented
principles,
operational
procedures,
applications
limitations
key
technologies
(ie,
FMT);
furthermore,
provided
evidence
works
through
especially
SCFA-
BSH-producing
bacteria),
metabolites
IS,
pCS,
SCFAs),
intestinal
barrier
alleviate
This
will
be
beneficial
constructing
microecological
pathways
treatment
future.
Keywords:
ecosystem,
herb,
disease,
co-housing,
Foods,
Год журнала:
2024,
Номер
13(15), С. 2360 - 2360
Опубликована: Июль 26, 2024
Hyperlipidemia
is
a
chronic
disease
that
difficult
to
cure,
and
long-term
pharmacotherapy
may
have
negative
consequences.
Dietary
therapy
very
promising
strategy,
Chinese
rice
wine
(Huangjiu)
will
play
an
important
role
because
of
its
many
biologically
active
components.
In
this
work,
the
alleviating
effect
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 10, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
caused
by
insulin
resistance
(IR)
and
insufficient
secretion.
Its
characteristic
pathophysiological
processes
involve
the
interaction
of
multiple
mechanisms.
In
recent
years,
globally,
prevalence
T2DM
has
shown
sharp
rise
due
to
profound
changes
in
socio-economic
structure,
persistent
influence
environmental
factors,
complex
role
genetic
background.
It
worth
noting
that
most
patients
show
significant
IR,
which
further
exacerbates
difficulty
progression
prevention.
process
extensively
exploring
pathogenesis
T2DM,
dynamic
equilibrium
gut
microbes
its
diverse
activities
have
increasingly
emphasized
central
T2DM.
Bile
acids
(BAs)
metabolism,
as
crucial
link
between
development
not
only
precisely
regulates
lipid
absorption
metabolism
but
also
profoundly
influences
glucose
homeostasis
energy
balance
through
intricate
signaling
pathways,
thus
playing
pivotal
IR
This
review
aims
delve
into
specific
mechanism
BAs
contribute
especially
emphasizing
how
mediate
transformation
based
on
current
traditional
Chinese
medicine
research.
Ultimately,
it
seeks
offer
new
insights
prevention
treatment
Diet,
genetics,
environment
intricately
sculpt
microbiota
influencing
T2DM-IR.
The
research
illuminated
impact
single
herbal
medicine,
TCM
formulae,
external
therapeutic
methods
such
electroacupuncture
pool
perturbations
structure.
affects
well
sensitivity.
Additionally,
pathways
including
BA-FXR-SHP,
BA-FXR-FGFR15/19,
BA-FXR-NLRP3,
BA-TGR5-GLP-1,
BAs-TGR5/FXR
been
identified
significantly
alter
blood
levels
improve
IR.
These
findings
novel
approaches
for
enhancing
managing
disorders
among
with
