ABSTRACT
The
utilization
of
nanoformulations
derived
from
natural
products
for
the
treatment
many
human
diseases,
including
cancer,
is
a
rapidly
developing
field.
Conventional
therapies
used
cancer
have
limited
efficacy
and
greater
number
adverse
effects.
Hence,
it
imperative
to
develop
innovative
anticancer
drugs
with
superior
effectiveness.
Among
diverse
array
compounds,
resveratrol,
curcumin,
epigallocatechin
gallate
(EGCG)
gained
considerable
attention
in
recent
years.
Despite
their
strong
properties,
medicinally
significant
phytochemicals
such
as
EGCG
certain
disadvantages,
solubility
water,
stability,
bioavailability
problems.
Encapsulating
these
poly(lactic‐
co
‐glycolic
acid)
(PLGA),
polymer
that
nontoxic,
biodegradable,
biocompatible,
an
effective
method
delivering
medication
tumor
location.
In
addition,
PLGA
nanoparticles
can
be
modified
targeting
molecules
specifically
target
cells,
thereby
improving
effectiveness
fighting
tumors.
Combining
plant‐based
medicine
(phytotherapy)
nanotechnology
clinical
environment
has
potential
enhance
improve
overall
health
outcomes
patients.
Therefore,
crucial
comprehensive
understanding
different
aspects
advancements
using
PLGA‐based
nanocarriers
phytochemicals.
This
review
addresses
most
delivery
systems
EGCG,
emphasizing
possibility
resolving
issues
related
therapeutic
compounds.
Biotechnology and Bioengineering,
Год журнала:
2024,
Номер
121(5), С. 1469 - 1485
Опубликована: Март 28, 2024
Abstract
The
carbon‐based
nanostructures
have
led
to
the
development
of
theranostic
nanoplatforms
for
simultaneous
diagnosis
and
therapy
due
their
effective
cell
membrane‐penetration
ability,
low
degree
cytotoxicity,
excellent
pore
volume,
substantial
chemical
stability,
reactive
surface.
In
last
few
years,
extensive
efforts
were
made
design
multifunctional
nanoplatform
strategies
based
on
carbon
nanostructures,
involving
multimodal
imaging,
controlled
drug
release
capabilities,
sensing
in
vitro,
efficient
loading
capacity,
therapy.
Carbon
graphene
quantum
dots
(CQDs
GQDs)
recent
entrants,
contingently
being
assessed
delivery
bioimaging.
With
advancements,
these
ignited
remarkable
research
interest
are
now
widely
evaluated
diagnosis,
bioimaging,
sensing,
applications.
decade
has
witnessed
electrical,
optical,
biocompatible
properties
since
inception.
It
is
presumed
that
both
them
high
potential
as
carriers
would
serve
next
generation
approaches
address
numerous
unresolved
therapeutic
challenges.
This
review
examined
advances
CQD
GQD
applications,
challenges,
future
perspectives
pave
way
further
studies
future.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
Journal of Molecular Liquids,
Год журнала:
2023,
Номер
391, С. 123363 - 123363
Опубликована: Окт. 16, 2023
Quercetin
(QC)
is
a
promising
cancer
drug,
though
its
poor
solubility
and
quick
release
reduce
bioavailability,
thus
limiting
current
applications.
In
this
research,
new
hydrogel
nanocomposite
comprising
zinc
oxide
nanoparticles
(ZnONPs),
agarose,
polyacrylic
acid
(PAA),
was
designed
to
load
QC.
Spherical
nanocarriers
were
prepared
via
environmentally
friendly
simple
double
emulsion
approach
by
injecting
PAA/Aga/ZnONPs
coated
SPAN
80
surfactant
hydrophobic
olive
oil
phase.
The
nanoemulsions
characterized
different
techniques
assess
the
impact
of
ZnONPs
on
PAA/Aga
pH-sensitive
as
novel
platform
for
direct
administration
FTIR
XRD
analysis
confirmed
presence
all
components
in
final
formulation.
FE-SEM
images
revealed
spherical
shape
surface
homogeneity
nanocarriers,
zeta
potential
measurements
corroborated
their
colloidal
stability.
addition
ZnONPS
increased
drug
loading
from
41.25%
47.50%
encapsulation
efficiency
83.0%
87.25%.
A
slower
observed
at
pH
7.4
periods
time
shorter
than
96
h,
corroborating
pH-sensitivity
nanoemulsions.
Drug
data
5.4
fitted
well
First-order
equation,
while
better
described
Korsmeyer
Peppas
model.
reduction
MCF7
living
cells
compared
control
sample
indicates
vitro
cytotoxicity
ZnONPs.
number
late
apoptotic
PAA/Aga/ZnONPs/QC
(37.55%)
higher
that
other
formulations
(ZnONPs,
PAA/Aga/ZnONPs),
which
may
be
due
controlled
slow
QC
PAA/Aga/ZnONPs/QC.
Therefore,
these
green,
biocompatible
biodegradable
show
great
sustained
against
breast
cancer.
