3D Printing‐Based Hydrogel Dressings for Wound Healing

Advanced Science, Год журнала: 2024, Номер 11(47)

Опубликована: Ноя. 18, 2024

Abstract Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of best candidates for ideal wound dressings most feasible choices printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic mechanical properties, 3D can promptly accurately create with complex bioactive structures potential promote tissue regeneration healing. Herein, a comprehensive review multi‐functional printing‐based hydrogel healing is presented. The first summarizes techniques dressings, including photo‐curing, extrusion, inkjet, laser‐assisted printing. Then, properties design approaches series bioinks composed natural, synthetic, composite polymers described. Thereafter, application in variety environments discussed depth, hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, machine learning‐assisted therapy. Finally, challenges prospects

Язык: Английский

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Horseradish peroxidase/hydrogen peroxide-driven photothermally enhanced hydrogel loaded with black rice extract for treating infected skin wound

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140827 - 140827

Опубликована: Фев. 1, 2025

Язык: Английский

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Green synthesis-inspired antibacterial, antioxidant and adhesive hydrogels with ultra-fast gelation and hemostasis for promoting infected skin wound healing

Acta Biomaterialia, Год журнала: 2024, Номер 184, С. 156 - 170

Опубликована: Июнь 17, 2024

Язык: Английский

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A review of polysaccharide hydrogels as materials for skin repair and wound dressing: Construction, functionalization and challenges

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135838 - 135838

Опубликована: Сен. 1, 2024

Язык: Английский

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Cotton Fabric-Reinforced Hydrogels with Excellent Mechanical and Broad-Spectrum Photothermal Antibacterial Properties

Polymers, Год журнала: 2024, Номер 16(10), С. 1346 - 1346

Опубликована: Май 9, 2024

Antibacterial hydrogel wound dressings hold great potential in eliminating bacteria and accelerating the healing process. However, it remains a challenge to fabricate that simultaneously exhibit excellent mechanical photothermal antibacterial properties. Here we report development of polydopamine-functionalized graphene oxide (rGO@PDA)/calcium alginate (CA)/Polypyrrole (PPy) cotton fabric-reinforced hydrogels (abbreviated as rGO@PDA/CA/PPy FHs) for tackling bacterial infections. The properties were greatly enhanced by fabric reinforcement an interpenetrating structure, while broad-spectrum based on effect obtained incorporating PPy rGO@PDA. Results indicated FHs exhibited superior tensile strength both warp (289 ± 62.1 N) weft directions (142 23.0 N), similarly fabric. By rGO@PDA, swelling ratio was significantly decreased from 673.5% 236.6%, conversion performance with temperature elevated 45.0 °C. Due synergistic rGO@PDA PPy, bacteria-eliminating efficiency S. aureus (0.57%) E. coli (3.58%) after exposure NIR 20 min. We believe design could serve guideline developing improved infected-wound treatment.

Язык: Английский

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Vat Photopolymerization of CeO2-Incorporated Hydrogel Scaffolds with Antimicrobial Efficacy

Materials, Год журнала: 2025, Номер 18(5), С. 1125 - 1125

Опубликована: Март 2, 2025

We herein demonstrate the utility of gelatin methacryloyl (GelMA)/poly(ethylene glycol) diacrylate (PEGDA)-cerium oxide (CeO2) hydrogel inks for manufacturing scaffolds with antimicrobial efficacy by vat photopolymerization. For uniform blending GelMA/PEGDA hydrogels, CeO2 nanoparticles a round shape were synthesized precipitation method coupled calculation at 600 °C. In addition, they had highly crystalline phases and desired chemical structures (oxidation states Ce3+ Ce4+) required outstanding efficacy. A range GelMA/PEGDA-CeO2 different contents (0% w/v, 0.1% 0.5% 1% 5% w/v respect to distilled water content) manufactured. The photopolymerization behavior, mechanical properties, biological properties (swelling biodegradation behaviors) characterized optimize content. produced highest content (5% w/v) showed reasonable (compressive strength = 0.56 ± 0.09 MPa compressive modulus 0.19 0.03 MPa), high swelling ratio (1063.3 10.9%), rate (remaining weight after 28 days 39.6 2.3%). Furthermore, (the number colony-forming units 76 44.6 (×103)). macroporous tightly controlled porous could be manufactured

Язык: Английский

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Preparation of bacterial cellulose-based antimicrobial materials and their applications in wound dressing: A review

Materials & Design, Год журнала: 2025, Номер unknown, С. 113820 - 113820

Опубликована: Март 1, 2025

Язык: Английский

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A Comprehensive Review on Stimuli-Responsive Nanomaterials: Advancements in Wound Healing and Tissue Regeneration

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Язык: Английский

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A Multifunctional Hydrogel for Infected Chronic Wounds Management: Integrated pH Sensing, Photothermal Therapy, and Ion Release

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

ABSTRACT Chronic wound healing is often compromised by bacterial infection, and pH changes strongly correlate with infection. Therefore, the development of dressings capable real‐time monitoring, antimicrobial activity, tissue repair crucial for effective management infected chronic wounds. This study reports a novel multifunctional composite hydrogel (GM‐C‐mBG@P) synthesized incorporating microwave‐synthesized carbon quantum dots (CQDs) polydopamine‐modified mesoporous bioactive glass nanoparticles (mBG@P) into modified gelatin methacryloyl (GelMA). The incorporated polydopamine (PDA) confers excellent photothermal properties to hydrogel, enabling activity. Under 360 nm UV excitation, fluorescence intensity CQDs in GM‐C‐mBG@P exhibits strong linear correlation pH, monitoring. Furthermore, mBG@P can gradually dissolve calcium, silicon, boron, other functional ions enhance bioactivity functionality accelerate healing. These findings suggest that has potential serve as promising dressing treatment

Язык: Английский

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Integration of Hydrogels and 3D Bioprinting Technologies for Chronic Wound Healing Management

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

The integration of hydrogel-based bioinks with 3D bioprinting technologies presents an innovative approach to chronic wound management, which is particularly challenging treat because its multifactorial nature and high risk complications. Using precise deposition techniques, significantly alters traditional care paradigms by enabling the fabrication patient-specific dressings that imitate natural tissue properties. Hydrogels are notably beneficial for these applications their abundant water content mechanical properties, promote cell viability pathophysiological processes healing, such as re-epithelialization angiogenesis. This article reviews key printing significance in enhancing structural functional outcomes wound-care solutions. Challenges bioink viscosity, viability, printability addressed, along discussions on cross-linking stability constructs. potential revolutionize management rests capacity generate remedies expedite healing minimize infection risks. Nevertheless, further studies clinical trials necessary advance therapies from laboratory use.

Язык: Английский

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