Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

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Oligonucleotide based nanogels for cancer therapeutics

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131401 - 131401

Published: April 4, 2024

Language: Английский

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Hypoxia-Targeted Responsive Delivery of Doxorubicin and Digoxin for Synergistic Treatment of Triple-Negative Breast Cancer

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

To enhance the therapeutic efficacy and safety of triple-negative breast cancer (TNBC) treatment, we developed a hypoxia-responsive drug delivery system utilizing digoxin (DIG) to inhibit HIF-1α sensitize TNBC doxorubicin (DOX). DIG, cardiac steroid with well-characterized pharmacological mechanism, was encapsulated in micelles composed methoxy-polyethylene glycol (mPEG) poly(lactic acid) (PLA) copolymers, incorporating an azobenzene (AZO) trigger for hypoxia-sensitive release. The loading ratio DOX DIG optimized based on DIG's minimum effective dose. In vitro vivo studies demonstrated that efficiently delivered their payload hypoxic tumor regions, enabling rapid DIG-mediated inhibition enhanced sensitivity DOX, leading significant suppression both primary growth pulmonary metastasis. This study presents promising clinically feasible strategy other hypoxia-driven malignancies.

Language: Английский

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Preparation and evaluation of near-infrared and pH dual-responsive mesoporous carbon nanospheres for controlled drug release

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130699 - 130699

Published: March 1, 2025

Language: Английский

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Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3520 - 3520

Published: July 26, 2024

Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering rich source bioactive compounds with therapeutic potential. However, the clinical application TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, development advanced polymer nanocarriers has emerged promising strategy delivery TCMs. This review focuses on introduction common active recent advancements in design enhancing efficacy safety We begin discussing unique properties inherent associated their delivery. then delve into types polymeric nanocarriers, including micelles, vesicles, hydrogels, drug conjugates, highlighting The main body presents comprehensive analysis state-of-the-art nanocarrier systems introduces impact stability, bioavailability TCM components. On basis this, we provide an outlook future directions underscores transformative potential revolutionizing delivery, pathway to harness full while ensuring modern medical context.

Language: Английский

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Polyesters and Polyester Nano- and Microcarriers for Drug Delivery

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2503 - 2503

Published: Sept. 3, 2024

Many therapies require the transport of therapeutic compounds or substances encapsulated in carriers that reduce or, if possible, eliminate their direct contact with healthy tissue and components immune system, which may react to them as something foreign dangerous patient’s body. To date, inorganic nanoparticles, solid lipids, micelles micellar aggregates, liposomes, polymeric micelles, other polymer assemblies were tested drug carriers. Specifically, using polymers creates a variety options prepare nanocarriers tailored chosen needs. Among polymers, aliphatic polyesters are particularly important group. The review discusses controlled synthesis poly(β-butyrolactone)s, polylactides, polyglycolide, poly(ε-caprolactone), copolymers containing polymacrolactone units double bonds suitable for preparation functionalized nanoparticles. Discussed syntheses molar masses ranging from few thousand 106 and, case chiral centers chains, microstructure. presents also collection methods useful drug-loaded nanocarriers: classical, developed mastered more recently (e.g., nanoprecipitation), forgotten but still great potential (by nanoparticles process comprising monomer drug). article describes in-vitro model in-vivo studies brain-targeted drugs based on polyester-containing brief update clinical polyester nanocarrier formulation approved application clinics South Korea treatment breast, lung, ovarian cancers.

Language: Английский

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Revolutionizing Lung Cancer Treatment with Smart Pulmonary Drug Delivery Nanosystems

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106158 - 106158

Published: Sept. 6, 2024

Language: Английский

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Niosomes: A Revolution in Sustainable and Targeted Drug Delivery-Green Synthesis, Precision Medicine, and Beyond

Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

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Advances in polysaccharide‐based materials for biomedical and pharmaceutical applications: A comprehensive review

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Polysaccharides, the most abundant biopolymers in nature, have attracted attention of researchers and clinicians due to its practicality biomedical pharmaceutical sciences. These biomaterials high bioavailability play structural functional roles living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides marine (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. possess unique physicochemical (such as surface groups, solubility, stability), mechanical strength tensile), antioxidant activity, biocompatibility, biodegradability, renewability, non-immunogenicity) characteristics which made them excellent platforms for a wide variety Ease extraction different preparation approaches mentioned other potential properties that further improved They drug/bioactive encapsulation capacity sustained/controlled release manner vivo microenvironments. The anti-inflammatory immunomodulation, stimuli-responsive release, passive active delivery considered features these indicated practical applications sciences, biosensors, tissue engineering, implantation, wound healing, vascular grafting, vaccines. This review highlights advances polysaccharide-based materials

Language: Английский

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Antimicrobial materials based on photothermal action and their application in wound treatment

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Considering the increasing abundance of antibiotic-resistant bacteria, novel antimicrobial approaches need to be investigated. Photothermal therapy (PTT), an innovative noninvasive therapeutic technique, has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms. However, when used isolation, PTT requires higher-temperature conditions effectively eradicate thereby potentially harming healthy tissues inducing new inflammation. This study aims present a comprehensive review nanomaterials with intrinsic properties, materials relying on photothermal action, using drug delivery along their applications antimicrobials. Additionally, synergistic mechanisms these are elucidated. The provides reference for developing multifunctional nanoplatforms treating bacterially infected wounds.

Language: Английский

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