Journal of Health and Rehabilitation Research,
Год журнала:
2024,
Номер
4(1), С. 1701 - 1705
Опубликована: Март 31, 2024
Background:
Flavonoids
are
recognized
for
their
extensive
health
benefits,
including
antioxidant,
anti-inflammatory,
antimicrobial,
and
neuroprotective
effects.
Traditional
methods
flavonoid
extraction,
often
dependent
on
toxic
solvents
high
energy
inputs,
have
prompted
the
exploration
of
more
sustainable
efficient
extraction
techniques.
This
movement
aligns
with
global
shift
towards
greener
methodologies
that
promise
to
enhance
purity
yield
these
vital
phytochemicals
therapeutic
purposes.
Objective:
In
this
hypothesis-driven
study,
we
aimed
evaluate
effectiveness
advanced
green
technologies—microwave-assisted
(MAE),
supercritical
fluid
(SFE),
ultrasound-assisted
(UAE)—for
isolating
flavonoids
from
botanical
sources.
A
secondary
objective
was
assess
antioxidant
capabilities
extracted
flavonoids,
thereby
linking
efficiency
process
bioactivity
compounds.
Methods:
The
study
utilized
MAE,
SFE,
UAE
extract
a
predetermined
plant
source,
optimizing
parameters
each
method
maximize
activity.
quantitatively
measured
in
mg
per
gram
dry
material,
while
capacity
evaluated
using
DPPH
(2,2-diphenyl-1-picrylhydrazyl)
assay,
focusing
percentage
radical
scavenging
Results:
Our
findings
indicated
MAE
most
method,
producing
120
mg/g
an
85%
SFE
followed,
yields
100
90
mg/g,
capacities
80%
75%
activity,
respectively.
These
results
not
only
supported
our
hypothesis
techniques
could
outperform
traditional
extracting
but
also
highlighted
as
superior
technique
terms
both
efficacy.
Conclusion:
validates
potential
technologies,
particularly
microwave-assisted
effective
alternatives
conventional
methods.
By
extracts,
technologies
pave
way
significant
advancements
pharmaceutical
nutraceutical
industries,
fostering
deeper
understanding
utilization
wellness.
Microorganisms,
Год журнала:
2024,
Номер
12(12), С. 2502 - 2502
Опубликована: Дек. 4, 2024
This
review
describes
the
enhanced
classification
of
polyphenols
into
flavonoids,
lignans,
phenolic
acids,
stilbenes,
and
tannins.
Its
focus
is
natural
sources
an
in-depth
discussion
their
antibacterial,
antifungal,
antiviral
activity.
Besides
a
broad
literature
overview,
this
paper
contains
authors'
experimental
data
according
to
some
daily
consumed
vegetables
such
as
tomatoes,
different
varieties
onion,
garlic,
parsley,
cayenne
pepper
probable
relation
these
activities
polyphenols.
The
isolation
via
conventional
ultrasonic,
pressurized
liquids
pulse-field
extractions,
well
methods
for
detection
determination,
are
interpreted
well.
main
mechanisms
by
which
inhibit
growth
bacteria,
fungi,
viruses,
protein
synthesis,
cell
membrane
destabilization,
ROS
production
induction,
in
focus.
Data
on
polyphenol
concentrations
respective
MIC
or
inhibition
zone
diameters
bacterial
fungal
species
suppressing
viral
replication
depicted.
toxicity
vitro,
ex
vivo,
vivo
towards
microorganisms
human/animal
cells,
safety
applied
clinical
industrial
applications
expanded.
also
characterizes
antimicrobial
effects
chemically
synthesized
derivatives.
Biotechnological
advances
reported,
especially
entrapment
biocompatible
nanoparticles
enhance
bioavailability
efficacy.
Polyphenols
promising
exploring
molecules'
novel
substances
paving
path
effective
agents'
discovery,
taking
consideration
positives
negatives.
Foods,
Год журнала:
2025,
Номер
14(3), С. 453 - 453
Опубликована: Янв. 30, 2025
This
study
aimed
to
optimize
the
extraction
conditions
for
a
valuable
source
of
antioxidants:
seaweed.
Therefore,
ten
seaweed
samples
were
subjected
solid–liquid
(SLE),
where
(biomass
(g):
solvent
(mL)
ratio,
temperature,
and
time)
optimized
using
response
surface
methodology
(RSM).
The
seaweeds
also
subcritical
water
(SWE)
(140
190
°C)
ultrasound-assisted
(UAE)
(10
20
min).
antioxidant
capacity
extracts
was
determined
through
ferric-reducing
power
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid).
total
phenolic
content
revealed
significance
temperature
biomass;
ratio
parameters
in
process
with
higher
generally
promoting
release
compounds.
Furthermore,
applying
RSM
allowed
identification
optimal
establishment
predictive
models
that
can
be
industrial-scale
processes.
potency
composite
index
(APCI)
shows
SWE
at
°C
stands
out,
E.
bicyclis
reaching
an
APCI
score
46.27%.
AGREEprep
evaluation
showed
UAE
is
most
sustainable
method,
achieving
highest
(0.69).
results
this
contribute
development
efficient
standardized
protocols
each
species,
allowing
maximum
yield
antioxidants.
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1279 - 1279
Опубликована: Март 12, 2025
Four
aromatic
and
therapeutic
plants,
Thymus
vulgaris,
Rosmarinus
officinalis,
Pimpinella
anisum,
Foeniculum
vulgare,
were
examined
in
this
comparative
study.
The
objectives
to
assess
its
phytochemical
composition;
polyphenol,
flavonoid,
tannin
content;
antioxidant
antibacterial
activity;
bioactive
molecule
identification;
critical
trace
element
quantification.
Its
aqueous
organic
extracts
examined,
focusing
on
ethanolic
extracts.
extract’s
ability
neutralize
free
radicals
was
validated
by
studies
tests,
underscoring
their
role
preventing
oxidative
stress.
An
Ultra-Performance
Liquid
Chromatography—High-Resolution
Mass
Spectrometry
Orbitrap
Exploris
120
(UPLC–HRMS
Orbitrap)
used
identify
the
chemicals,
results
showed
a
variety
of
compounds
having
properties.
important
elements
found
these
plants
also
measured
using
Graphite
Furnace-Atomic
Absorption
Spectrometer
(GF-AAS).
These
components
are
essential
biological
characteristics
especially
capacities.
Among
extracts,
it
observed
that
officinalis
vulgare
exhibited
MIC
3.91
µg/mL
against
Staphylococcus.
Additionally,
R.
demonstrated
Escherichia
coli.
All
data
interpreted
shown
principal
component
analysis.
grouped
explained
statistical
method,
which
revealed
strong
association
between
abundance
chemicals
four
under
investigation.
Foods,
Год журнала:
2025,
Номер
14(6), С. 1017 - 1017
Опубликована: Март 17, 2025
The
brown
seaweed
Saccharina
latissima
is
an
abundant,
although
yet
underutilized,
source
of
natural
bioactive
compounds
commonly
found
in
western
regions.
In
recent
years,
algae
have
garnered
attention
as
promising
sources
polyphenols,
particularly
phlorotannins.
recovery
these
relevant
components
by
eco-friendly
and
energy-efficient
methods
with
solvents
GRAS
(Generally
recognized
safe)
contributes
to
minimizing
environmental
impact,
promotes
sustainability.
Pressurized
liquid
extraction
(PLE)
microwave-assisted
(MAE)
optimized
Box-Behnken
design
(BBD)
were
explored
for
this
purpose.
evaluated
considering
the
process
yield
quality
recovered
extracts
phenolic
phlorotannin
levels,
their
antioxidant
capacity
was
assessed
DPPH
ABTS
assays.
MAE
techniques
(80
°C,
2%
EtOH/Water
at
40
mL
g-1)
PLE2
°C
water)
showed
highest
extract
yields,
increases
65.76%
37.36%,
respectively,
compared
CRE.
also
achieved
higher
TPC
(ABTS)
values
61.88%
80.39%,
respectively.
(optimized)
increased
53.90%
36.42%,
Regression
analysis
confirmed
accuracy
models
assessing
interaction
parameters
(adjustment
p
<
0.05
adequacy
R2
>
0.86).
Therefore,
study
presents
eco-efficient
approaches
recovering
antioxidants
from
algae,
contributing
valorization
resources
industry
enhancing
application.
