Green Approach to Novel Flavonoid Extraction: Purification Methods and Therapeutic Benefits for Optimizing Health and Wellness Initiatives. DOI Creative Commons
Umar Farooq,

Laraib Nadeem,

Pirya Nangdev

et al.

Journal of Health and Rehabilitation Research, Journal Year: 2024, Volume and Issue: 4(1), P. 1701 - 1705

Published: March 31, 2024

Background: Flavonoids are recognized for their extensive health benefits, including antioxidant, anti-inflammatory, antimicrobial, and neuroprotective effects. Traditional methods flavonoid extraction, often dependent on toxic solvents high energy inputs, have prompted the exploration of more sustainable efficient extraction techniques. This movement aligns with global shift towards greener methodologies that promise to enhance purity yield these vital phytochemicals therapeutic purposes. Objective: In this hypothesis-driven study, we aimed evaluate effectiveness advanced green technologies—microwave-assisted (MAE), supercritical fluid (SFE), ultrasound-assisted (UAE)—for isolating flavonoids from botanical sources. A secondary objective was assess antioxidant capabilities extracted flavonoids, thereby linking efficiency process bioactivity compounds. Methods: The study utilized MAE, SFE, UAE extract a predetermined plant source, optimizing parameters each method maximize activity. quantitatively measured in mg per gram dry material, while capacity evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, focusing percentage radical scavenging Results: Our findings indicated MAE most method, producing 120 mg/g an 85% SFE followed, yields 100 90 mg/g, capacities 80% 75% activity, respectively. These results not only supported our hypothesis techniques could outperform traditional extracting but also highlighted as superior technique terms both efficacy. Conclusion: validates potential technologies, particularly microwave-assisted effective alternatives conventional methods. By extracts, technologies pave way significant advancements pharmaceutical nutraceutical industries, fostering deeper understanding utilization wellness.

Language: Английский

The Future of Algal Proteins: Innovations in Extraction and Modifications, Functional Properties, and Sustainable Food Applications DOI Creative Commons
Sunil Pipliya, Sitesh Kumar, Rakesh Kumar Gupta

et al.

Future Foods, Journal Year: 2025, Volume and Issue: unknown, P. 100549 - 100549

Published: Jan. 1, 2025

Language: Английский

Citations

2
Discovery of sugar-based natural framework as phytopathogenic virus capsid protein inhibitors using a state-of-the-art multiple screening strategy DOI
Jinhong Hu, Zhenxing Li, Yue Ding

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140075 - 140075

Published: Jan. 18, 2025

Language: Английский

Citations

1
Optimizing the fucoidan extraction using Box-Behnken Design and its potential bioactivity DOI
Mostafa M. El‐Sheekh,

Eman A. Alwaleed,

Wafaa M.A. Kassem

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134490 - 134490

Published: Aug. 5, 2024

Language: Английский

Citations

6
Antibacterial, Antifungal, Antiviral Activity, and Mechanisms of Action of Plant Polyphenols DOI Creative Commons

Slavena Davidova,

Angel S. Galabov,

Galina Satchanska

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2502 - 2502

Published: Dec. 4, 2024

This review describes the enhanced classification of polyphenols into flavonoids, lignans, phenolic acids, stilbenes, and tannins. Its focus is natural sources an in-depth discussion their antibacterial, antifungal, antiviral activity. Besides a broad literature overview, this paper contains authors' experimental data according to some daily consumed vegetables such as tomatoes, different varieties onion, garlic, parsley, cayenne pepper probable relation these activities polyphenols. The isolation via conventional ultrasonic, pressurized liquids pulse-field extractions, well methods for detection determination, are interpreted well. main mechanisms by which inhibit growth bacteria, fungi, viruses, protein synthesis, cell membrane destabilization, ROS production induction, in focus. Data on polyphenol concentrations respective MIC or inhibition zone diameters bacterial fungal species suppressing viral replication depicted. toxicity vitro, ex vivo, vivo towards microorganisms human/animal cells, safety applied clinical industrial applications expanded. also characterizes antimicrobial effects chemically synthesized derivatives. Biotechnological advances reported, especially entrapment biocompatible nanoparticles enhance bioavailability efficacy. Polyphenols promising exploring molecules' novel substances paving path effective agents' discovery, taking consideration positives negatives.

Language: Английский

Citations

4
Impressive merits of Nanocellulose driving sustainable beauty DOI
Xiangyu Wang,

Chunyan Zhong,

Yuguang Zhong

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123270 - 123270

Published: Jan. 14, 2025

Language: Английский

Citations

0
Cultivation of Ulva sp. and Gracilaria sp. associated with a recirculating aquaculture system DOI
Ângela Luzia Branco Pinto Duarte,

Guilherme Carvalhal,

Joana Assunção

et al.

Journal of Applied Phycology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

0
Optimized Extraction Protocols for Bioactive Antioxidants from Commercial Seaweeds in Portugal: A Comparative Study of Techniques DOI Creative Commons

Francisca Santos,

Cristina Soares, Stephanie L. Morais

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 453 - 453

Published: Jan. 30, 2025

This study aimed to optimize the extraction conditions for a valuable source of antioxidants: seaweed. Therefore, ten seaweed samples were subjected solid–liquid (SLE), where (biomass (g): solvent (mL) ratio, temperature, and time) optimized using response surface methodology (RSM). The seaweeds also subcritical water (SWE) (140 190 °C) ultrasound-assisted (UAE) (10 20 min). antioxidant capacity extracts was determined through ferric-reducing power 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid). total phenolic content revealed significance temperature biomass; ratio parameters in process with higher generally promoting release compounds. Furthermore, applying RSM allowed identification optimal establishment predictive models that can be industrial-scale processes. potency composite index (APCI) shows SWE at °C stands out, E. bicyclis reaching an APCI score 46.27%. AGREEprep evaluation showed UAE is most sustainable method, achieving highest (0.69). results this contribute development efficient standardized protocols each species, allowing maximum yield antioxidants.

Language: Английский

Citations

0
Biosynthesis of non-toxic TiO2 nanoparticles using polysaccharide rich ⁠marine algae Caulerpa racemose for inhibition of biofilm-producing bacteria and brine shrimp Artemia DOI
Govindan Rajivgandhi, Mudaliar Mahesh Margoni,

Malathi Mathiazhagan

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136483 - 136483

Published: Feb. 1, 2025

Language: Английский

Citations

0
Phytochemical Analysis, Antioxidant and Antibacterial Activities, Minerals Element Profiling, and Identification of Bioactive Compounds by UPLC-HRMS Orbitrap in Four Aromatic and Medicinal Plants DOI Creative Commons

Aicha Boubker,

Abdelmoula El Ouardi,

Taha El Kamli

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1279 - 1279

Published: March 12, 2025

Four aromatic and therapeutic plants, Thymus vulgaris, Rosmarinus officinalis, Pimpinella anisum, Foeniculum vulgare, were examined in this comparative study. The objectives to assess its phytochemical composition; polyphenol, flavonoid, tannin content; antioxidant antibacterial activity; bioactive molecule identification; critical trace element quantification. Its aqueous organic extracts examined, focusing on ethanolic extracts. extract’s ability neutralize free radicals was validated by studies tests, underscoring their role preventing oxidative stress. An Ultra-Performance Liquid Chromatography—High-Resolution Mass Spectrometry Orbitrap Exploris 120 (UPLC–HRMS Orbitrap) used identify the chemicals, results showed a variety of compounds having properties. important elements found these plants also measured using Graphite Furnace-Atomic Absorption Spectrometer (GF-AAS). These components are essential biological characteristics especially capacities. Among extracts, it observed that officinalis vulgare exhibited MIC 3.91 µg/mL against Staphylococcus. Additionally, R. demonstrated Escherichia coli. All data interpreted shown principal component analysis. grouped explained statistical method, which revealed strong association between abundance chemicals four under investigation.

Language: Английский

Citations

0
Green Extraction Methods Applied to the Brown Macroalga Saccharina latissima: Assessing Yield, Total Phenolics, Phlorotannins and Antioxidant Capacity DOI Creative Commons
Jonas da Silva, Luana Cristina dos Santos, Elena Ibáñez

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1017 - 1017

Published: March 17, 2025

The brown seaweed Saccharina latissima is an abundant, although yet underutilized, source of natural bioactive compounds commonly found in western regions. In recent years, algae have garnered attention as promising sources polyphenols, particularly phlorotannins. recovery these relevant components by eco-friendly and energy-efficient methods with solvents GRAS (Generally recognized safe) contributes to minimizing environmental impact, promotes sustainability. Pressurized liquid extraction (PLE) microwave-assisted (MAE) optimized Box-Behnken design (BBD) were explored for this purpose. evaluated considering the process yield quality recovered extracts phenolic phlorotannin levels, their antioxidant capacity was assessed DPPH ABTS assays. MAE techniques (80 °C, 2% EtOH/Water at 40 mL g-1) PLE2 °C water) showed highest extract yields, increases 65.76% 37.36%, respectively, compared CRE. also achieved higher TPC (ABTS) values 61.88% 80.39%, respectively. (optimized) increased 53.90% 36.42%, Regression analysis confirmed accuracy models assessing interaction parameters (adjustment p < 0.05 adequacy R2 > 0.86). Therefore, study presents eco-efficient approaches recovering antioxidants from algae, contributing valorization resources industry enhancing application.

Language: Английский

Citations

0