Recent developments in non-starch Ipomoea batatas (L.) Lam. polysaccharides: extractions and purifications, structural characteristics, pharmacological activities, structure-activity relationships, and applications A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142808 - 142808
Опубликована: Апрель 1, 2025
Язык: Английский
New insights into the intestinal barrier through “gut-organ” axes and a glimpse of the microgravity’s effects on intestinal barrier
Hong‐Yun Nie,
Jun Ge,
Guo-Xing Huang
и другие.
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 10, 2024
Gut
serves
as
the
largest
interface
between
humans
and
environment,
playing
a
crucial
role
in
nutrient
absorption
protection
against
harmful
substances.
The
intestinal
barrier
acts
initial
defense
mechanism
non-specific
infections,
with
its
integrity
directly
impacting
homeostasis
health
of
human
body.
primary
factor
attributed
to
impairment
previous
studies
has
always
centered
on
gastrointestinal
tract
itself.
In
recent
years,
concept
"gut-organ"
axis
gained
significant
popularity,
revealing
profound
interconnection
gut
other
organs.
It
speculates
that
disruption
these
axes
plays
pathogenesis
progression
damage.
evaluation
function
detection
enterogenic
endotoxins
can
serve
"detecting
agents"
for
identifying
early
functional
alterations
heart,
kidney,
liver,
thereby
facilitating
timely
intervention
disorders.
Simultaneously,
consolidating
may
also
present
potential
therapeutic
approach
attenuate
damage
Studies
have
demonstrated
diverse
signaling
pathways
their
corresponding
key
molecules
are
extensively
involved
pathophysiological
regulation
barrier.
Aberrant
activation
dysregulated
expression
play
pivotal
process
impairment.
Microgravity,
being
predominant
characteristic
space,
potentially
exert
influence
barriers.
We
will
discuss
interaction
damage,
further
elucidate
underlying
summarize
various
components
under
microgravity.
This
review
aims
offer
novel
perspective
comprehending
etiology
molecular
mechanisms
injury
well
prevention
management
microgravity
environment.
Язык: Английский
Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 24, 2024
The
dysfunction
of
gut
microbiome
and
bile
acid
metabolism
might
cause
the
incidence
relapse
ulcerative
colitis
(UC).
Thus,
natural
products
have
been
considered
effective
for
UC
through
regulation
acid.
In
this
study,
we
evaluated
regulatory
effect
berberine
on
in
UC.
Results
showed
that
relative
abundances
beneficial
bacteria
a
decreasing
trend
model,
taurine
conjugated
acids
increased
from
liver
tissue
to
colon
tissue.
Berberine
inhibited
colonization
harmful
promoted
primary
metabolism.
Moreover,
used
multi-omics
technology
(metagenomics,
metabolomics,
transcriptomics
technology)
reveal
restored
intestinal
barrier
function
acid/S1PR2/RhoA/ROCK
pathway.
result
transmission
electron
microscopy
directly
damaged
mucosal
was
repaired
treatment.
This
study
revealed
treatment
influence
Язык: Английский
Apolipoprotein A-I: Potential Protection Against Intestinal Injury Induced by Dietary Lipid
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 5711 - 5721
Опубликована: Авг. 1, 2024
The
intestinal
barrier
system
protects
the
human
body
from
harmful
factors,
by
continuously
renewing
epithelium,
tight
junctions
and
enteric
microbes.
However,
dietary
fat
can
harm
epithelial
enhancing
gut
permeability.
In
recent
years,
Apolipoprotein
A-I
has
attracted
much
attention
because
of
its
anti-inflammatory
properties.
Numerous
studies
have
demonstrated
that
regulate
mucosal
immune
cells,
inhibit
progression
inflammation,
promote
proliferation
repair,
maintain
physical
function;
it
also
angiogenesis,
thereby
improving
local
circulation.
This
article
is
intended
to
elucidate
mechanism
which
improves
damage
caused
review
role
in
maintaining
homeostasis.
Язык: Английский