Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study

BMJ, Год журнала: 2023, Номер unknown, С. e076990 - e076990

Опубликована: Ноя. 22, 2023

Abstract Objective To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within recommended schedule) against post-covid-19 condition (PCC). Design Population based cohort study. Setting Swedish Covid-19 Investigation for Future Insights—a Epidemiology Approach using Register Linkage (SCIFI-PEARL) project, a register study in Sweden. Participants All adults (≥18 years) with registered between 27 December 2020 9 February 2022 (n=589 722) largest regions Individuals were followed from infection until death, emigration, vaccination, reinfection, PCC diagnosis (ICD-10 code U09.9), or end follow-up (30 November 2022), whichever came first. who had received at least one vaccine before considered vaccinated. Main outcome measure The was clinical PCC. Vaccine estimated Cox regressions adjusted age, sex, comorbidities (diabetes cardiovascular, respiratory, psychiatric disease), number healthcare contacts during 2019, socioeconomic factors, dominant virus variant time infection. Results Of 299 692 vaccinated individuals covid-19, 1201 (0.4%) follow-up, compared 4118 (1.4%) 290 030 unvaccinated individuals. any associated reduced risk (adjusted hazard ratio 0.42, 95% confidence interval 0.38 to 0.46), 58%. individuals, 21 111 only, 205 650 doses, 72 931 three more doses. dose, 21%, 59%, 73%, respectively. Conclusions results this suggest strong association receiving findings highlight importance reduce population burden

Язык: Английский

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The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research

Antimicrobial Stewardship & Healthcare Epidemiology, Год журнала: 2023, Номер 3(1)

Опубликована: Янв. 1, 2023

We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals.Systematic review/meta-analysis.We searched PubMed, Cumulative Index to Nursing Allied Health, EMBASE, Cochrane Central Register Controlled Trials, Scopus, Web Science from December 1, 2019, June 2, 2023, for studies evaluating COVID-19 vaccine (VE) individuals who received two doses vaccine. A condition was defined as any symptom that present four or more weeks after infection. calculated pooled diagnostic odds ratio (DOR) (95% confidence interval) between unvaccinated individuals. Vaccine estimated 100% x (1-DOR).Thirty-two with 775,931 evaluated effect conditions, which, twenty-four were included in meta-analysis. The DOR 0.680 CI: 0.523-0.885) an VE 32.0% (11.5%-47.7%). 36.9% (23.1%-48.2%) those before infection 68.7% (64.7%-72.2%) three stratified analysis demonstrated no protection infection.Receiving complete prior contracting virus resulted significant reduction throughout study period, including during Omicron era. increase when supplementary administered.

Язык: Английский

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Long COVID in low-income and middle-income countries: the hidden public health crisis

The Lancet, Год журнала: 2023, Номер 402(10408), С. 1115 - 1117

Опубликована: Авг. 28, 2023

Язык: Английский

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Prevalence and risk factors of long COVID 6–12 months after infection with the Omicron variant among nonhospitalized patients in Hong Kong

Journal of Medical Virology, Год журнала: 2023, Номер 95(6)

Опубликована: Июнь 1, 2023

Abstract Long COVID has been reported among patients with COVID‐19, but little is known about the prevalence and risk factors associated long 6–12 months after infection Omicron variant. This a large‐scale retrospective study. A total of 6242 out 12 950 nonhospitalized subjects all ages SARS‐CoV‐2 (confirmed by polymerase chain reaction/rapid antigen test) during dominant outbreak (December 31, 2021–May 6, 2022) in Hong Kong were included. Prevalence COVID, frequencies symptoms, analyzed. Three thousand four hundred thirty (55.0%) at least one symptom. The most symptom was fatigue (1241, 36.2%). Female gender, middle age, obesity, comorbidities, vaccination infection, having more presenting fatigue/chest tightness/headache/diarrhea acute stage illness identified as for COVID. Patients who had received three or doses vaccine not lower (adjusted odds ratio 1.105, 95% confidence interval 0.985–1.239, p = 0.088). Among vaccine, there no significant difference between CoronaVac BNT162b2 ( > 0.05). can lead to proportion infection. Further investigation needed uncover mechanisms underlying development determine impact various such vaccines.

Язык: Английский

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Long COVID is a double curse in low-income nations — here’s why

Nature, Год журнала: 2024, Номер 625(7993), С. 20 - 22

Опубликована: Янв. 3, 2024

Язык: Английский

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Incidence and burden of long COVID in Africa: a systematic review and meta-analysis

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Дек. 6, 2023

Abstract Long COVID, also known as “post-acute sequelae of COVID-19,” affects at least 65 million individuals worldwide with a wide spectrum symptoms that may last weeks, months, or permanently. Its epidemiology and burden in Africa are unclear. This meta-analysis examines long-term COVID-19 effects the WHO African Region. A systematic search several databases was carried out up to 12 February 2023 including observational studies from countries reporting cumulative incidence long COVID signs symptoms. Only conducted were included. Several sensitivity meta-regression analyses performed. Among 1547 papers initially screened, 25 included, consisting 29,213 participants. The any symptomatology 48.6% (95% CI 37.4–59.8) psychiatric conditions most frequent, particularly post-traumatic stress disorder reaching 25% 21.1–30.4). Higher age ( p = 0.027) hospitalization 0.05) associated higher frequency COVID. poses significant Africa, concerning conditions. study recommends identifying at-risk people defining treatment strategies recommendations for long-COVID patients. High-quality addressing this condition setting urgently needed.

Язык: Английский

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From Acute Infection to Prolonged Health Consequences: Understanding Health Disparities and Economic Implications in Long COVID Worldwide

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(3), С. 325 - 325

Опубликована: Март 11, 2024

The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. COVID is characterized by recurring inflammation across multiple organ systems. Diagnosis can be challenging, influenced factors like demographics, comorbidities, immune responses. impacts various systems have neuropsychological effects. Health disparities, particularly related to race, contribute higher burden infection ongoing minority populations. Managing entails addressing spectrum that encompass physical, cognitive, psychological aspects. recovery period for with vary significantly, the severity disease, hospitalization, age. Currently, there are no universally effective treatments, although certain interventions show promise, necessitating further research. Self-management rehabilitation programs provide relief, but more research needed establish their effectiveness. Preventive measures such vaccination use antiviral medications metformin. It imperative conduct develop evidence-based guidelines gain better understanding long-term implications COVID-19. could substantial economic impact on labor market, productivity, healthcare expenditures, overall growth. To address challenges complications face, focus strategies promoting telework flexible work arrangements accommodate diverse symptoms, chronic fatigue other In conclusion, this review emphasizes multifaceted complexity need its potential health impacts.

Язык: Английский

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Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study

Brain Communications, Год журнала: 2024, Номер 6(2)

Опубликована: Янв. 1, 2024

Abstract Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial symptoms are closely associated post-acute sequelae SARS-CoV-2 (severe acute respiratory syndrome 2; PANSC) female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we report the prevalence risk factors PANSC among hospitalized adults investigate differences between males females resolution over time. included altered consciousness/confusion, fatigue/malaise, anosmia, dysgeusia muscle ache/joint pain, which information was collected at index hospitalization during follow-up assessments. The analysis considered time individual all symptoms. resulting times were modelled by Weibull regression, assuming mixed-case interval censoring, age as covariates. model results summarized cumulative probability functions age-adjusted sex-adjusted median We 6862 2019, who had participants 57 years (39.2% females). Males similar baseline characteristics, except more (versus females) admitted intensive care unit (30.5 20.3%) received mechanical ventilation (17.2 11.8%). Approximately 70% patients multiple first (median = 102 days). Fatigue (49.9%) myalgia/arthralgia (45.2%) most prevalent follow-up. reported in generally higher males) for At 12 months, anosmia resolved patients, although fatigue, consciousness myalgia remained unresolved >10% cohort. Females longer (5.2 3.4 months) those than one symptom. multivariable analysis, shorter (hazard ratio 1.53; 95% confidence 1.39–1.69). Intensive admission 0.68; 0.60–0.77). Post-discharge stroke uncommon (0.3% 0.5% males). Despite methodological challenges involved collection survey data, international multi-centre prospective cohort demonstrated following high. Symptom took resolve males. This supported fact while sicker illness, disproportionately affected PANSC.

Язык: Английский

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Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome

Infection, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Язык: Английский

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Symptom trajectories of post-COVID sequelae in patients with acute Delta or Omicron infection in Bergen, Norway

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Март 5, 2024

Introduction A substantial proportion of the over 700 million COVID-19 cases world-wide experience long-term symptoms. The objectives this study were to compare symptom trajectories and risk factors for post-COVID-19 condition after Delta Omicron infection. Methods This consecutively recruited patients with SARS-CoV-2 infection from November 2021 March 2022. We recorded demographics, comorbidities, vaccination status, sick leave, 18 symptoms during acute 4 months. primary outcome measures Secondary work school absenteeism. Results followed a cohort 1,374 non-hospitalized in Bergen, Norway, at three time points. median age was 39.8 years 11% children <16 years. Common upper respiratory waned follow-up. Fatigue remained common (40%) until months (37%). Four post-infection, reported increased frequencies dyspnea (from 15% illness 25% months, p < 0.001), cognitive 9 32%, 0.001) depression 1 17%, 0.001). Patients infected less (22% versus 27%, = 0.046) smell/taste problems (5% 19%, follow-up than those Comorbidities female sex persistent Ten percent leave illness, reduced absenteeism (adjusted ratio: 0.36, 95% confidence interval: 0.15, 0.72, 0.008). Conclusion At home-isolated overall comparable burden, but patients. Several It is worrying that dyspnea, neurocognitive symptoms, particularly depression, significantly first Previous protective against prolonged leave.

Язык: Английский

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