International Journal of Pharmaceutics, Год журнала: 2024, Номер 667, С. 124900 - 124900
Опубликована: Ноя. 3, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2022, Номер 625, С. 122122 - 122122
Опубликована: Авг. 18, 2022
Язык: Английский
Процитировано
84
Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 164 - 164
Опубликована: Янв. 3, 2023
Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, amalgamated preparation different systems aims deal with these limitations. The novel prepared by incorporation nano-emulsion into gel improves stability enables for both immediate controlled release. focus on nano-emulgel has also increased due its ability achieve targeted delivery, ease application, absence gastrointestinal degradation or first pass metabolism, safety profile. This review focuses formulation components topical pharmacokinetics profiles.
Язык: Английский
Процитировано
77
Nanomaterials, Год журнала: 2023, Номер 13(10), С. 1688 - 1688
Опубликована: Май 21, 2023
Microemulsions are novel drug delivery systems that have garnered significant attention in the pharmaceutical research field. These possess several desirable characteristics, such as transparency and thermodynamic stability, which make them suitable for delivering both hydrophilic hydrophobic drugs. In this comprehensive review, we aim to explore different aspects related formulation, characterization, applications of microemulsions, with a particular emphasis on their potential cutaneous delivery. shown great promise overcoming bioavailability concerns enabling sustained Thus, it is crucial thorough understanding formulation characterization order optimize effectiveness safety. This review will delve into types composition, factors affect stability. Furthermore, microemulsions skin be discussed. Overall, provide valuable insights advantages improving
Язык: Английский
Процитировано
33
eFood, Год журнала: 2023, Номер 4(4)
Опубликована: Июль 24, 2023
Abstract Natural emulsifier‐stabilized emulsions have garnered a significant amount of attention in many industries including foods, pharmaceuticals, cosmetics, health care formulations, paints, polymer blends and oils. Various methods been used to improve the bioavailability functional substances, such as microemulsions, nanoemulsions, Pickering emulsions, complexes. Over recent years, increasingly investigated due their potential drug‐delivery vehicles for wide range application. In this review, we discuss some publications area various food filed, detailed analysis mechanisms different preparation, compared with composition conditions on stability. addition, above affect properties but also activity. According current research status, suggestions are put forward further study.
Язык: Английский
Процитировано
23
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4021 - 4040
Опубликована: Май 1, 2024
Abstract: Cataract is a leading cause of blindness globally, and its surgical treatment poses significant burden on global healthcare. Pharmacologic therapies, including antioxidants protein aggregation reversal agents, have attracted great attention in the cataracts recent years. Due to anatomical physiological barriers eye, effectiveness traditional eye drops for delivering drugs topically lens hindered. The advancements nanomedicine present novel promising strategies addressing challenges drug delivery lens, development nanoparticle formulations that can improve penetration into anterior segment enable sustained release medications. This review introduces various cutting-edge systems cataract treatment, highlighting their physicochemical properties surface engineering optimal design, thus providing impetus further innovative research potential clinical applications anti-cataract drugs. Keywords: nanomedicine, cataract, ocular barrier, system
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153036 - 153036
Опубликована: Июнь 13, 2024
Liquid-liquid systems play an important role in several industrial processes. Their separation efficiency determines the product purity and yield to a great extent. In recent years, there has been noticeable trend miniaturise liquid-liquid separators as process intensification strategy. However, adoption of miniaturised is lagging behind development technology. This review assesses latest research on five types separators: mini-hydrocyclones, helical separators, axial flow membrane filters microchannel separators. Special focus given geometric design, operating conditions, combination integration The advantages limitations these are highlighted, well challenges potential solutions for their at scale. analysis intended guide selection different scenarios bridge gaps between lab large-scale applications.
Язык: Английский
Процитировано
8
AAPS PharmSciTech, Год журнала: 2022, Номер 23(6)
Опубликована: Июль 7, 2022
Язык: Английский
Процитировано
34
Drug Discovery Today, Год журнала: 2023, Номер 28(4), С. 103521 - 103521
Опубликована: Фев. 6, 2023
Язык: Английский
Процитировано
18
Saudi Pharmaceutical Journal, Год журнала: 2024, Номер 32(6), С. 102100 - 102100
Опубликована: Май 14, 2024
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of GA. The preparation method capability B-MEG screened optimized using central composite design, Franz diffusion cell experiments, split-split plot design. Skin irritation tests were performed in guinea pigs. anti-gout effects evaluated mice. comprised 50 % pH 7.4 phosphate buffered saline, 4.48 ethyl oleate, 31.64 tween 80, 13.88 glycerin, 2 borneol, 0.5 clove oil xanthan gum, with content (10.42 ± 0.08) mg/g particle size (15.71 0.41) nm. After 12 h, cumulative amount permeated from (672.14 44.11) μg·cm
Язык: Английский
Процитировано
6
Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 112(12), С. 3109 - 3119
Опубликована: Июль 8, 2023
Язык: Английский
Процитировано
14