Indian Journal of Biochemistry and Biophysics,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Psoriasis
is
an
autoimmune
and
inflammatory
disease,
that
significantly
affects
human
well-being.
The
chances
of
relapses
psoriasis
are
high
even
after
steroidal
therapy
other
medicines.
proper
treatment
unavailable
due
to
a
lack
understanding
the
pathophysiology
this
disease.
Phosphodiesterase
enzyme
subtypes
(PDE-4B
PDE-4D)
have
been
implicated
in
because
inhibitor
elevates
level
C-Amp
hence
reduces
features
inflammation.
Recent
researches
also
demonstrated
role
psoriasis.
Therefore,
study,
molecular
docking
analysis
was
carried
out
on
twelve
natural
ligands
proven
be
anti-psoriatic
candidates
via
preclinical
studies
different
animal
models
but
their
mechanism
action
not
explored
yet.
chemical
structures
were
prepared
using
ChemSketch
2015
(Free
version).
AutoDock
Tool
1.5.6
employed
for
studies.
results
indicated
all
interacted
with
targets
active
sites
Capsaicin
Hypericin
inhibited
PDE-4B
Gossypol
PDE-4D
enzymes,
respectively,
interacting
responsible
amino
acids
demonstrating
significant
binding
energies.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(29), С. 10877 - 10900
Опубликована: Июль 11, 2023
There
is
growing
interest
in
reducing
the
number
of
synthetic
products
or
additives
and
replacing
them
with
natural
ones.
The
pharmaceutical,
cosmetic,
food
industries
are
especially
focused
on
bioactive
chemicals
isolated
from
plants
microorganisms.
main
challenge
here
to
develop
efficient
ecological
methods
for
their
isolation.
According
strategies
rules
sustainable
development
green
chemistry,
solvents
environmentally
friendly
technologies
must
be
used.
application
deep
eutectic
as
biodegradable
seems
a
promising
alternative
traditional
methods.
They
classified
being
but,
most
importantly,
very
extraction
media
compared
organic
solvents.
aim
this
review
present
recent
findings
extraction,
well
biological
activities
possible
applications
plant
ingredients,
namely,
phenolics,
flavonoids,
terpenes,
saponins,
some
others.
This
paper
thoroughly
reviews
modern,
ecological,
use
(DESs).
newest
findings,
factors
influencing
efficiency
such
water
content,
hydrogen
bond
donor
acceptor
types,
systems,
also
discussed.
New
solutions
major
problem
separating
DESs
extract
solvent
recycling
presented.
Pharmaceutical Nanotechnology,
Год журнала:
2024,
Номер
13(1), С. 70 - 89
Опубликована: Янв. 26, 2024
Phytopharmaceuticals,
derived
from
natural
sources,
manifest
tremendous
potential
for
therapeutic
applications.
Nevertheless,
effective
delivery
of
these
bio-actives
presents
significant
challenges.
A
breakthrough
in
fortifying
phytopharmaceuticals
within
phosphatidylcholine
is
a
promising
remedy
to
overcome
solubility,
permeability,
and
other
related
drawbacks.
This
intrinsic
lipid,
which
obtained
both
synthetic
confers
numerous
benefits,
encompassing
heightened
augmented
bioavailability,
enhanced
stability.
The
conjugation
with
enables
improved
dermal
permeation,
absorption,
targeted
distribution,
the
possibility
synergistic
results,
eventually
improving
efficacy.
Additionally,
use
enriched
route
overcoming
limitations
imposed
by
conventional
techniques,
encouraging
more
treatments.
review
provides
thorough
analysis
phosphatidylcholine-
incorporated
as
nanomedicine
variables
that
significantly
affect
their
Moreover,
elaborates
on
how
improves
tissue
distribution
boosts
phytopharmaceuticals.
Further,
underscores
significance
nano-formulation
strategies,
analytical
methodologies,
forthcoming
prospects
propel
this
field
forward.
Furthermore,
emphasizes
inherent
innovative
approach
while
highlighting
importance
additional
research
endeavors
collaborative
initiatives
unlock
benefits
phosphatidylcholinefortified
phytopharmaceuticals,
enhancing
patient
well-being.
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1384 - 1384
Опубликована: Окт. 28, 2024
Dermatoses
are
among
the
most
prevalent
non-fatal
conditions
worldwide.
Given
this
context,
it
is
imperative
to
introduce
safe
and
effective
dermatological
treatments
address
diverse
needs
concerns
of
individuals.
Transdermal
delivery
technology
offers
a
promising
alternative
compared
traditional
administration
methods
such
as
oral
or
injection
routes.
Therefore,
review
focuses
on
recent
achievements
nanocarrier-based
transdermal
for
therapy,
which
summarizes
strategies
enhance
skin
penetration
using
various
nanocarriers
including
vesicular
nanocarriers,
lipid-based
emulsion-based
polymeric
nanocarrier
according
pathogenesis
common
dermatoses.
The
fundamentals
physiology
structure
routes
introduced.
Moreover,
mechanisms
due
utilization
hydration,
system
deformability,
disruption
stratum
corneum,
surface
charge,
tunable
particle
size
outlined
well.
Cosmetics,
Год журнала:
2022,
Номер
9(6), С. 127 - 127
Опубликована: Ноя. 25, 2022
A
rising
volume
of
the
literature
acknowledges
significance
nanotechnology
in
cosmetics
industry,
particularly
with
invention
and
use
techniques
based
on
niosomes
to
generate
unique
formulations
both
medicinal
aesthetic
benefits.
The
current
study’s
objectives
are
undertake
a
comprehensive
review
previously
published
data
applications
give
succinct
summary
that
data.
Preferred
Reporting
standards
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines
were
used
design
review.
core
concept
keywords
derived
from
research
question
using
SPIDER
tool.
main
steps
this
included:
question,
preliminary
research,
search
strategy,
searching
database,
exclusion
inclusion
criteria,
approval
by
authors,
title
abstract
screening,
reporting
number
selected,
full
text
download
reading,
manual
(Google
Scholar,
Scopus,
WoS),
extraction
quality
assessment,
double
checking,
manuscript
writing,
revision,
submission.
After
thorough
analysis,
it
was
discovered
cosmetic
product’s
impact
significantly
improved
when
created
utilising
technology.
majority
cosmeceutical
niosomes’
skin
hair
products
demonstrated
an
enhanced
therapeutic
effect.
These
discoveries
may
contribute
treatment
conditions
under
umbrella
niosomes.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1724 - 1724
Опубликована: Июнь 14, 2023
Atopic
dermatitis
(AD)
is
a
chronic
eczematous
inflammatory
disease
that
may
arise
from
environmental,
genetic,
and
immunological
factors.
Despite
the
efficacy
of
current
treatment
options
such
as
corticosteroids,
approaches
are
mainly
focused
on
symptom
relief
present
certain
undesirable
side
effects.
In
recent
years,
isolated
natural
compounds,
oils,
mixtures,
and/or
extracts
have
gained
scientific
attention
because
their
high
efficiency
moderate
to
low
toxicity.
promising
therapeutic
effects,
applicability
healthcare
solutions
somewhat
limited
by
instability,
poor
solubility,
bioavailability.
Therefore,
novel
nanoformulation-based
systems
been
designed
overcome
these
limitations,
thus
enhancing
potential,
promoting
capacity
drugs
properly
exert
action
in
AD-like
skin
lesions.
To
best
our
knowledge,
this
first
literature
review
has
summarizing
loaded
with
ingredients,
specifically
for
management
AD.
We
suggest
future
studies
should
focus
robust
clinical
trials
confirm
safety
effectiveness
natural-based
nanosystems,
paving
way
more
reliable
AD
treatments.
Biomedicines,
Год журнала:
2023,
Номер
11(6), С. 1589 - 1589
Опубликована: Май 30, 2023
Psoriasis
(PSO)
is
an
inflammatory
skin
condition
that
causes
a
variety
of
diseases
and
significantly
decreases
the
life
characteristics
patients,
substantially
diminishes
patients’
quality
life.
PSO
usually
impairs
linked
to
various
disorders.
Inflammation
pathology
does
not
only
damage
psoriatic
skin;
it
shows
how
impinges
other
body
parts.
Many
variables
interact
with
one
another
can
impact
etiology
psoriasis
directly
or
indirectly.
has
effect
on
approximately
2%
world’s
population,
significant
progress
been
made
in
comprehending
treating
alternative
by
novel
drug
delivery
systems.
Topical,
systemic,
biological,
biomaterials,
phototherapy
are
some
useful
therapies
for
PSO.
Nonetheless,
topical
treatments
remain
gold
standard
moderate
The
applicability
several
nanocarrier
systems,
such
as
lipid
nanoparticles,
metallic
certain
phytocompounds,
briefly
explored.
present
review
focuses
mainly
traditional
therapeutic
strategies
well
breakthroughs
nanoformulations
methods
anti-psoriatic
drugs.
Cosmetics,
Год журнала:
2025,
Номер
12(1), С. 21 - 21
Опубликована: Янв. 24, 2025
This
study
focuses
on
optimizing
the
extraction
conditions
for
antioxidants
from
fenugreek
seeds
(Trigonella
foenum-graecum
L.)
through
ultrasound-assisted
with
aim
of
creating
a
stable
and
effective
cosmetic
formulation.
RSM
was
used
to
optimize
parameters
ultrasonic
power
60%,
50%
ethanol
concentration
10
min.
Under
those
conditions,
extract
showed
phenolic-rich
profile,
total
phenolic
content
equivalent
18.56
mg
GAE/g
DM
radical
scavenging
activity
63.24%.
Chromatographic
analysis
further
confirmed
abundance
compounds,
epicatechin
identified
as
major
compound
at
22.58
mg/g
DM.
The
exhibited
considerable
antibacterial
number
bacterial
strains,
it
no
cell
toxicity
RAW
267.4
cells,
supporting
its
safe
use
in
products.
formulation
maintained
high
stability,
pH
values
6.25
6.35,
viscosity
7941.69
7956.70
cp,
less
color
change
after
90
days
preservation
under
varied
temperature
conditions.
These
findings
validate
extract’s
potential
producing
stable,
eco-friendly,
product,
thus
bringing
skin
health
benefits
driving
sustainable
methods
industry.
