Unveiling the potential of inorganic nanoarchitecture-mediated photothermal therapy: An illustration on melanoma
Aachal Hedaoo,
Pooja Khairnar,
Ganesh Vambhurkar
и другие.
European Polymer Journal,
Год журнала:
2024,
Номер
216, С. 113282 - 113282
Опубликована: Июль 2, 2024
Язык: Английский
Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing
Stem Cell Reviews and Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Язык: Английский
Multifunctional Dual-Layer Microneedles Loaded with Selenium-Doped Carbon Quantum Dots and Astilbin for Ameliorating Diabetic Wound Healing
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101739 - 101739
Опубликована: Апрель 1, 2025
Diabetic
wounds
(DW)
represent
a
significant
clinical
challenge
due
to
chronic
inflammation,
excessive
oxidative
stress,
and
impaired
angiogenesis,
all
of
which
hinder
effective
tissue
regeneration.
Existing
drug
delivery
systems
often
fail
achieve
sustained
targeted
therapeutic
efficacy.
In
this
study,
we
developed
novel
dissolvable
dual-layer
methacrylated
gelatin
(GelMA)
microneedle
(MN)
co-loading
selenium-doped
carbon
quantum
dots
(Se-CQDs)
Astilbin
(AST)
for
enhanced
DW
treatment.
The
outer
layer,
enriched
with
Se-CQDs,
rapidly
scavenges
reactive
oxygen
species
(ROS),
effectively
alleviating
stress
at
the
wound
site.
Sequentially,
inner
layer
releases
AST,
exerting
potent
anti-inflammatory
pro-angiogenic
effects.
Preliminary
findings
suggest
these
effects
may
involve
modulation
cytoskeletal
dynamics
peroxisome
function,
contributing
endothelial
cell
migration
angiogenesis.
This
controlled,
sequential
release
MN
establishes
low-oxidative,
microenvironment,
thereby
promoting
angiogenesis
accelerating
repair.
pioneering
integration
AST-loaded
hydrogels
offers
synergistic
strategy,
setting
new
standard
advanced
diabetic
care
substantial
promise.
Язык: Английский
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Intraoral
delivery
of
active
pharmaceutical
ingredients
(API)
is
an
attractive
approach
to
improve
their
local
therapeutic
efficacy
or
enable
systemic
delivery.
It
offers
several
advantages,
such
as
high
drug
concentration
at
the
intraoral
target
site
and
rapid
access
circulation
due
vascularization
oral
cavity,
bypassing
first‐pass
metabolism.
However,
limitations
need
be
addressed,
relatively
short
residence
time
formulations
applied
in
cavity
salivation,
swallowing
reflex,
tongue
movement,
well
poor
membrane
permeability
of,
particular,
hydrophilic
drugs.
Within
this
review,
a
comprehensive
summary
latest
strategies
formulation
approaches
field
provided,
focusing
on
those
pursued
by
academia
industry
overcome
challenges.
An
overview
provided
excipients
that
are
generally
recognized
safe
(GRAS)
utilized
enhance
systems,
mucoadhesive
materials,
enzyme
inhibitors,
permeation
enhancers.
Innovative
dosage
forms
outlined,
covering
solid,
semi‐solid,
liquid
systems
aerosols.
Future
trends,
including
self‐emulsifying
microneedles,
situ
bioprinting,
explored,
presenting
new
opportunities
for
Язык: Английский
Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Preparation and In Vitro/In Vivo Characterization of Mixed-Micelles-Loaded Dissolving Microneedles for Sustained Release of Indomethacin
Baojie Wang,
Langkun Liao,
Huihui Liang
и другие.
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1505 - 1505
Опубликована: Ноя. 22, 2024
Background/Objectives:
Indomethacin
(IDM)
is
commonly
used
to
treat
chronic
inflammatory
diseases
such
as
rheumatoid
arthritis
and
osteoarthritis.
However,
long-term
oral
IDM
treatment
can
harm
the
gastrointestinal
tract.
This
study
presents
a
design
for
encapsulating
within
mixed
micelles
(MMs)-loaded
dissolving
microneedles
(DMNs)
improve
sustain
transdermal
drug
delivery.
Methods:
Indomethacin-loaded
(IDM-MMs)
were
prepared
from
Soluplus®
Poloxamer
F127
by
means
of
thin-film
hydration
method.
The
MMs-loaded
DMNs
fabricated
using
two-step
molding
method
evaluated
storage
stability,
insertion
ability,
in
vitro
release,
penetration,
vivo
PK/PD
studies.
Results:
obtained
MMs
stable
at
4
°C
30
60
days.
penetration
was
remarkably
improved
compared
commercial
patch.
A
pharmacokinetic
demonstrated
that
had
relative
bioavailability
4.1
comparison
with
Furthermore,
showed
significantly
shorter
lag
time
than
patch,
well
more
plasma
concentration
without
MMs.
therapeutic
efficacy
examined
Complete
Freund's
Adjuvant-induced
mice.
DMN
effectively
reduced
severity,
resulting
decreased
paw
swelling,
index,
spleen
hyperplasia,
serum
IL-1β
TNF-α
levels.
Conclusions:
Our
findings
novel
an
effective
strategy
sustained
providing
alternate
route
anti-inflammatory
Язык: Английский