Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 9, 2023
Abstract
Escitalopram
(ETP)
has
poor
oral
bioavailability
due
to
its
low
water
solubility,
hence
the
goal
of
this
work
was
design
and
optimize
a
self-nano-emulsifying
drug
delivery
system
(SNEDDS).
Using
results
investigations
on
solubility
emulsification,
pseudo-ternary
phase
diagram
produced.
The
three
main
ingredients
chosen
for
formulation
were
polyethylene
glycol
400
(co-surfactant),
tween
80
(surfactant),
geranium
oil
(lipid).
ETP-SNEDDS
evaluated
size
particles
surface
charge.
Fourier
transforms
infrared
spectroscopy
(FTIR),
differential
scanning
calorimetry
(DSC)
thermogravimetric
analysis
(TGA)
used
evaluate
chemical
compatibility
thermal
stability.
Ex-vivo
permeability,
in
vitro
digestion,
dissolution
carried
out
compared
with
reference
tablets.
ETP-loaded
SNEDDS
comparison
control
Wistar
rats
(n
=
6).
With
droplet
145
nm,
polydispersity
index
0.120,
an
emulsification
period
almost
one
minute,
synthesized
thermodynamically
stable.
displayed
96%
FSSIF.
permeation
investigation
revealed
that,
ETP
powder
tablet,
respectively,
increased
penetration
by
4.2
3.1-folds.
enhancement
dissolution,
ex-vivo
permeability
found
significant
(p
<
0.05).
In
reference,
had
C
max
AUC
increases
5.34
4.71
fold,
respectively.
These
findings
suggested
that
would
be
promising
method
increasing
absorption
ETP.
Nanomedicine,
Год журнала:
2024,
Номер
19(25), С. 2065 - 2083
Опубликована: Авг. 15, 2024
To
developed
and
investigate
gallic
acid
(GA)
loaded
self-nanoemulsifying
drug
delivery
systems
(SNEDDS)
for
treating
onychomycosis
via
transungual
route.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(33), С. 8007 - 8032
Опубликована: Янв. 1, 2024
Inflammatory
skin
diseases,
such
as
psoriasis
and
atopic
dermatitis,
pose
significant
health
challenges
due
to
their
long-lasting
nature,
potential
for
serious
complications,
risks,
which
requires
treatments
that
are
both
effective
exhibit
minimal
side
effects.
Hydrogels
offer
an
innovative
solution
biocompatibility,
tunability,
controlled
drug
delivery
capabilities,
enhanced
treatment
adherence
minimized
effects
risk.
This
review
explores
the
mechanisms
guide
design
of
hydrogel
therapeutic
platforms
from
multiple
perspectives,
focusing
on
components
hydrogels,
adjustable
physical
chemical
properties,
interactions
with
cells
drugs
underscore
clinical
potential.
We
also
examine
various
agents
dermatitis
can
be
integrated
into
including
traditional
drugs,
novel
compounds
targeting
oxidative
stress,
small
molecule
biologics,
emerging
therapies,
offering
insights
advantages.
Additionally,
we
trial
data
evaluate
effectiveness
safety
hydrogel-based
in
managing
under
complex
disease
conditions.
Lastly,
discuss
current
future
opportunities
therapeutics
treating
improving
barrier
penetration
developing
multifunctional
highlight
enhance
long-term
stability.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
663, С. 124536 - 124536
Опубликована: Июль 27, 2024
Vesicants
are
chemical
warfare
agents
(CWAs)
capable
of
causing
severe
skin
damage
and
systemic
toxicity.
Melatonin,
known
for
its
anti-inflammatory
antioxidant
properties,
can
mitigate
the
effects
these
agents.
Self-nano-emulsifying
drug
delivery
systems
(SNEDDS)
containing
a
high
melatonin
concentration
(5
%,
50
mg/g)
were
optimized
using
quality-by-design
approach
from
biocompatible,
non-irritant
excipients
with
particle
size
about
100
nm.
The
melatonin-loaded
SNEDDS
showed
43-fold
greater
permeability
than
conventional
cream.
Chemical
stability
at
ambient
temperature
(25
°C)
was
maintained
one
year.
preparation
optimised
simple
mixing
method
compared
to
microfluidic
micromixers.
Mixing
successfully
achieved
3D-printed
(fused
deposition
modeling
or
stereolithography)
T-shaped
toroidal
chip
(with
channel
geometry
by
computational
fluid
dynamics),
resulting
in
scalable,
continuous
process
first
time
substantial
reduction
other
approaches.
No
statistically
significant
differences
observed
key
quality
attributes,
such
as
loading,
between
till
kinetic
equilibrium
solubility
is
reached
This
continuous,
cost-effective
improves
overall
efficiency
production,
reduces
cost
control
multiple
batches,
demonstrates
potential
manufacture
readily
customizable
micromixers
points
care,
military
bases.
Carbohydrate Polymers,
Год журнала:
2024,
Номер
349, С. 122966 - 122966
Опубликована: Ноя. 13, 2024
Atopic
dermatitis
(AD)
is
the
most
common
form
of
eczema
and
burdensome
skin
disease
globally,
affecting
nearly
223
million.
A
major
AD
predisposition
genetic
susceptibility,
barrier
integrity
cell-mediated
immunity.
Manifesting
as
red,
dry,
itchy
skin,
basic
treatment
involves
hydration
with
emollients.
Despite
their
effectiveness,
poor
patient
compliance
remains
a
drawback.
In
severe
cases,
medicated
emollients
are
used,
but
carry
risks,
including
thinning,
immunosuppression.
Hence,
hydrogels
have
emerged
promising
alternative
for
management
based
on
ability
to
improve
hydration,
attributed
hydrophilicity
high
water
retention
capacity.
Moreover,
researchers
loaded
various
compounds
management;
they
also
hold
potential
reduce
systemic
side
effects
commercial
drugs
by
enhancing
dermal
retention.
Hydrogels
address
challenges
non-greasy
texture
reduced
application
frequency.
Their
appeal
stems
from
versatility,
can
be
fabricated
varying
polymers.
Due
abundance,
this
review
focuses
polysaccharides
alginate,
cellulose,
chitosan,
hyaluronic
acid,
which
preferred
fabricating
natural
modified
AD.
It
briefly
explores
hydrogel
methods
key
models.
