Research Progress in The Application of Bioactive Peptides in Cosmeceutical Products DOI

Luwen Huang,

Shaojing Sun,

X. P. Zhang

и другие.

Academic Journal of Science and Technology, Год журнала: 2023, Номер 7(3), С. 258 - 263

Опубликована: Окт. 29, 2023

Consumer demand for natural source cosmeceutical products with protective and therapeutic functions has prompted the industry to look alternative active ingredients. Natural bioactive peptides have single or multifunctional biological properties, such as anti-aging, anti-inflammatory, antibacterial, antioxidant activities, etc., which can promote improvement of skin health by providing specific physiological functions, are ideal raw materials development medicinal cosmetics. In this paper, preparation characterization methods were reviewed, bioactivities related their potential applications introduced in detail, challenges opportunities developing peptide-based formulations expounded, so provide references application commercial field

Язык: Английский

Research progress on the PEGylation of therapeutic proteins and peptides (TPPs) DOI Creative Commons
Chunxiao Li, Ting Li,

Xinya Tian

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 8, 2024

With the rapid advancement of genetic and protein engineering, proteins peptides have emerged as promising drug molecules for therapeutic applications. Consequently, there has been a growing interest in field chemical modification technology to address challenges associated with their clinical use, including clearance from circulation, immunogenicity, physical instabilities (such aggregation, adsorption, deamination, clipping, oxidation, etc.), enzymatic degradation. Polyethylene glycol (PEG) offers an effective solution these issues due its favorable properties. This review presents recent progress development application PEGylated (TPPs). For this purpose, firstly, properties well classification PEG derivatives are described. Subsequently, detailed summary is provided on main sites TPPs factors that influence PEGylation. Furthermore, notable instances PEG-modified (including antimicrobial (AMPs), interferon, asparaginase antibodies) highlighted. Finally, we propose PEG, followed by analysis current status future prospects TPPs. work provides comprehensive literature while facilitating researchers utilizing polymers modify disease treatment.

Язык: Английский

Процитировано

18
Amphotericin B PLGA nanoparticles loaded dissolving microneedle patches in treating cutaneous fungal infections DOI Creative Commons
Ke Peng, Aiman Abu Ammar, Achmad Himawan

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106697 - 106697

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies DOI Creative Commons

Krittika Ralhan,

Kavita A. Iyer, Leilani Lotti Díaz

и другие.

ACS Infectious Diseases, Год журнала: 2024, Номер 10(5), С. 1483 - 1519

Опубликована: Май 1, 2024

The development of effective antibacterial solutions has become paramount in maintaining global health this era increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role combating infections throughout history. However, the emergence novel resistant strains necessitates constant innovation research. We analyzed data on antibacterials from CAS Content Collection, largest human-curated collection published scientific knowledge, which proven valuable for quantitative analysis knowledge. Our focuses mining Collection recent publications (since 2012). This article aims to explore intricate landscape research while reviewing advancement traditional emerging strategies. By delving into resistance mechanisms, paper highlights need find alternate strategies address growing concern.

Язык: Английский

Процитировано

14
How can we escape the ESKAPEs: Antimicrobial resistance mechanisms and what lies ahead? DOI Creative Commons
J. Kelly, Aaron C. Nolan, Merve S. Zeden

и другие.

PLoS Pathogens, Год журнала: 2024, Номер 20(6), С. e1012270 - e1012270

Опубликована: Июнь 13, 2024

The ESKAPE pathogens are a group of 6 nosocomial pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp., so-called, due to their ability "escape" from our current arsenal antimicrobials via variety mechanisms, leading them be multidrug resistant (MDR) [1].ESKAPE can possess the exchange plasmid-encoded resistance genes by horizontal gene transfer, which leads continual rise antimicrobial (AMR) in these pathogens.The critical or high-priority pathogen lists according World Health Organisation (WHO) [2] listed as urgent serious threats public health Centre for Disease Control Prevention (CDC) [3].Unfortunately, if nothing changes, we will facing consequences "post-antibiotic era," with staggering effect on increasing global healthcare costs worsening clinical outcomes [4].Despite differences between species (gram-positive gram-negative) within group, some overall strategies employed conserved them.This article summarises intrinsic acquired mechanisms discusses future therapeutic avenues that being explored fight against AMR.

Язык: Английский

Процитировано

10
Antimicrobial Peptides, Their Production, and Potential in the Fight Against Antibiotic-Resistant Pathogens DOI Creative Commons
Margarita Saubenova, Alexander Rapoport, Zhanerke Yermekbay

и другие.

Fermentation, Год журнала: 2025, Номер 11(1), С. 36 - 36

Опубликована: Янв. 17, 2025

The article reviews the literature on antimicrobial peptides (AMPs) that exhibit unique mechanisms, such as broad-spectrum activity, low development of resistance, and ability to modulate immune response host organism. Information is provided significant potential AMPs in fight against pathogens threatening human health food safety. Enrichment diet with biologically active obtained using proteolytic activity lactic acid bacteria (LAB) proposed a simple, accessible, viable alternative antibiotics does not have harmful side effect. review briefly covers methods for obtaining features LAB system responsible producing bioactive environment. It has been shown various strains makes it possible produce high-quality whey-based beverages different directions antagonistic opportunistic helps optimize gastrointestinal microbiota. assumed drinks can reduce dose antimicrobials combined therapy infectious diseases be preventive measure contagion spread resistance.

Язык: Английский

Процитировано

1
Three-dimensional printed polyelectrolyte construct containing mupirocin-loaded quaternized chitosan nanoparticles for skin repair DOI
Yasir Qasim Almajidi,

Rana Kadum Muslim,

Anmar A. Issa

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 136214 - 136214

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

6
Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic–Antimicrobial Peptide Conjugates DOI Creative Commons

Maria Cristina Bellucci,

Carola Romani,

Monica Sani

и другие.

Antibiotics, Год журнала: 2024, Номер 13(8), С. 783 - 783

Опубликована: Авг. 21, 2024

In recent years, bacterial resistance to conventional antibiotics has become a major concern in the medical field. The global misuse of clinics, personal use, and agriculture accelerated this resistance, making infections increasingly difficult treat rendering new ineffective more quickly. Finding is challenging due complexity mechanisms, high costs low financial incentives for development molecular scaffolds, stringent regulatory requirements. Additionally, innovation slowed, with many being modifications existing drugs rather than entirely classes. Antimicrobial peptides (AMPs) are valid alternative small-molecule offering several advantages, including broad-spectrum activity lower likelihood inducing their multifaceted mechanisms action. However, AMPs face challenges such as stability issues physiological conditions, potential toxicity human cells, production costs, difficulties large-scale manufacturing. A reliable strategy overcome drawbacks associated use combination therapy, namely simultaneous co-administration two or synthesis covalently linked conjugates. This review aims provide comprehensive overview literature on antibiotic-AMP conjugates, particular emphasis critically analyzing design synthetic strategies employed creation. addition synthesis, will also explore reported antibacterial these conjugates and, where available, examine any data concerning cytotoxicity.

Язык: Английский

Процитировано

5
Other routes of protein and peptide delivery: Transdermal, topical, uterine, and rectal DOI

Naazneen Surti,

Ashok Mahajan

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 433 - 487

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Interaction of Arginine and Tryptophan-Rich Short Antimicrobial Peptides with Membrane Models: A Combined Fluorescence, Simulations, and Theoretical Approach DOI
Bogdan Zorilă, Gheorghe Necula, Lorant Janosi

и другие.

Journal of Chemical Information and Modeling, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

The augmented increase in bacterial antimicrobial resistance necessitates the discovery of alternative molecules such as short peptides (AMPs) with activity and low cytotoxicity. While many have been studied, their selective affinity for versus mammalian membranes remains unclear. Here, we propose a complementary approach using state-of-the-art fluorescence experiments, molecular dynamics simulations, theoretical techniques. main goal this is to unravel energetics interactions AMPs different membrane models at lipid-water interface. We use Trp- Arg-rich AMPs, pure phosphatidylcholine (PC), an 85:15 mixture PC phosphatidylglycerol (PG) lipids model membranes, respectively. First, found that electrostatic interaction PG headgroups Arg enhances peptide mixed bilayers by 25-30%, leading increased hydrogen bonding stronger adhesion. Second, obtained Gibbs free energies revealed significantly distinct partitioning AMP interface two bilayers, suggesting qualitatively insertion method cationic into each models. These results highlight potential our selectivity context AMP-based rational design antibiotics.

Язык: Английский

Процитировано

0
Harnessing the Power of Antimicrobial Peptides: From Mechanisms to Delivery Optimization for Topical Infections DOI Creative Commons

Songhita Mukhopadhyay,

Souha H. Youssef, Yunmei Song

и другие.

Antibiotics, Год журнала: 2025, Номер 14(4), С. 379 - 379

Опубликована: Апрель 4, 2025

Antimicrobial peptides (AMPs) have emerged as promising agents for treating topical infections due to their enhanced biocompatibility and resistance systemic degradation. AMPs possess host immunomodulatory effects disintegrate bacterial cell membranes, a mechanism less prone microbial compared conventional antibiotics, making potential candidates antimicrobial delivery. The review discusses the challenges posed by (AMR) explores mechanisms which bacteria develop AMPs. authors provide detailed analysis of action AMPs, limitations, strategies improve efficacy. Conventional AMP delivery systems, including polymeric, synthetic, lipid-based nanoparticles cubosomes, face via efflux pump membrane modifications, protease enzyme release. This optimize these systems. Furthermore, market statistics growing interest in peptide antibiotics been explored this review. future research directions, such exploring gene-targeting approaches combat emerging against emphasize considering conformational stability peptides, skin microbiome’s nature at infection site, proteolytic developing efficient systems infections.

Язык: Английский

Процитировано

0