Russian Journal of Physical Chemistry A, Год журнала: 2024, Номер 98(14), С. 3504 - 3508
Опубликована: Дек. 1, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2024, Номер 662, С. 124485 - 124485
Опубликована: Июль 17, 2024
Язык: Английский
Процитировано
14
Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102393 - 102393
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
8
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 852 - 852
Опубликована: Июнь 25, 2024
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design drug delivery systems. In particular, introduction systems is a potential approach enhance uptake therapeutic agents deliver them at right time in amount concentration required site, as well open new strategies for effective illness treatment. this review, we provide basic understanding with an emphasis on use cyclodextrin-, polymer- surfactant-based These are very attractive because they biocompatible biodegradable nanomaterials multifunctional components. We also details considerations variety medical applications by employing several routes administration.
Язык: Английский
Процитировано
8
Results in Chemistry, Год журнала: 2024, Номер 12, С. 101878 - 101878
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
7
Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 564 - 586
Опубликована: Дек. 5, 2024
Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science
Язык: Английский
Процитировано
7
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 203, С. 114474 - 114474
Опубликована: Авг. 25, 2024
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 272, С. 132890 - 132890
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
4
Drug Discovery Today, Год журнала: 2025, Номер unknown, С. 104320 - 104320
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125611 - 125611
Опубликована: Апрель 1, 2025
A novel β-cyclodextrin-aza[5]helicene conjugate as theranostic platform for anticancer agents delivery in cancer cells is here reported. The carrier was synthesized via monotosylation of hydroxyethyl-β-cyclodextrin (HE-β-CD), followed by reaction with the aza[5]helicene, yielding corresponding ammonium tosylate salt. system characterized NMR, FTIR, UV-vis, and PL measurements, demonstrating favorable optical properties. suitability fluorescent to act smart drug therapy investigated choosing gemcitabine (GMC) a model drug. GMC inclusion inside evaluated experimental computational studies which confirmed formation 1:1 complex between β-CD GMC. within cavity led marked enhancement its water solubility. Biological tests conducted on A549 revealed high cell internalization (∼80 %) low cytotoxicity (IC50 = 262.7 µg mL-1) β-CD-aza[5]helicene conjugate. results obtained exploiting host-guest chemistry β-cyclodextrin combined unique photophysical properties aza[5]helicene could pave way new therapies, increasing therapeutic index endowed poor solubility systemic toxicity and, thanks inserted probe, following their release into biological pathways.
Язык: Английский
Процитировано
0