Russian Journal of Physical Chemistry A, Journal Year: 2024, Volume and Issue: 98(14), P. 3504 - 3508
Published: Dec. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124485 - 124485
Published: July 17, 2024
Language: Английский
Citations
14
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102393 - 102393
Published: June 24, 2024
Language: Английский
Citations
8
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 852 - 852
Published: June 25, 2024
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design drug delivery systems. In particular, introduction systems is a potential approach enhance uptake therapeutic agents deliver them at right time in amount concentration required site, as well open new strategies for effective illness treatment. this review, we provide basic understanding with an emphasis on use cyclodextrin-, polymer- surfactant-based These are very attractive because they biocompatible biodegradable nanomaterials multifunctional components. We also details considerations variety medical applications by employing several routes administration.
Language: Английский
Citations
8
Results in Chemistry, Journal Year: 2024, Volume and Issue: 12, P. 101878 - 101878
Published: Oct. 30, 2024
Language: Английский
Citations
7
Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586
Published: Dec. 5, 2024
Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science
Language: Английский
Citations
7
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 203, P. 114474 - 114474
Published: Aug. 25, 2024
Language: Английский
Citations
5
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132890 - 132890
Published: June 1, 2024
Language: Английский
Citations
4
Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104320 - 104320
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125611 - 125611
Published: April 1, 2025
A novel β-cyclodextrin-aza[5]helicene conjugate as theranostic platform for anticancer agents delivery in cancer cells is here reported. The carrier was synthesized via monotosylation of hydroxyethyl-β-cyclodextrin (HE-β-CD), followed by reaction with the aza[5]helicene, yielding corresponding ammonium tosylate salt. system characterized NMR, FTIR, UV-vis, and PL measurements, demonstrating favorable optical properties. suitability fluorescent to act smart drug therapy investigated choosing gemcitabine (GMC) a model drug. GMC inclusion inside evaluated experimental computational studies which confirmed formation 1:1 complex between β-CD GMC. within cavity led marked enhancement its water solubility. Biological tests conducted on A549 revealed high cell internalization (∼80 %) low cytotoxicity (IC50 = 262.7 µg mL-1) β-CD-aza[5]helicene conjugate. results obtained exploiting host-guest chemistry β-cyclodextrin combined unique photophysical properties aza[5]helicene could pave way new therapies, increasing therapeutic index endowed poor solubility systemic toxicity and, thanks inserted probe, following their release into biological pathways.
Language: Английский
Citations
0