3D printed infliximab suppositories for rectal biologic delivery

International Journal of Pharmaceutics X, Год журнала: 2023, Номер 5, С. 100176 - 100176

Опубликована: Март 8, 2023

Infliximab is a monoclonal antibody that plays an important role in the management and treatment of chronic inflammatory bowel diseases (IBD). Due to its macromolecular structure, delivery through oral route challenging, limiting administration only via parenteral route. The rectal offers alternative way for administering infliximab, allowing it be localised at disease site circumventing passage across alimentary canal thus, maintaining integrity bioactivity. Three-dimensional (3D) printing advanced production technology permits creation dose-flexible drug products from digital designs. current study assessed feasibility utilising semi-solid extrusion 3D fabrication infliximab-loaded suppositories local IBD. Various inks composed Gelucire® (48/16 or 44/14) mixed with coconut oil and/or purified water were investigated. It was shown following reconstitution water, infliximab solution can directly incorporated into ink 48/16 withstand process, resulting well-defined suppositories. Since content temperature are critical safeguarding infliximab's potency, effect changing composition parameters on biologic efficiency evaluated by measuring binding capacity (i.e., amount actively binds antigen exert effect). Despite loading assays showing remains intact printing, found incorporation isolation results ∼65% capacity. However, when added mixture, increases up ∼85%. These promising demonstrate has potential exploited as novel platform fabricating dosage forms containing biopharmaceuticals, avoiding patients' compliance issues observed injectables addressing their unmet needs.

Язык: Английский

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3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1448 - 1448

Опубликована: Май 10, 2023

3D printing technology in medicine is gaining great attention from researchers since the FDA approved first 3D-printed tablet (Spritam®) on market. This technique permits fabrication of various types dosage forms with different geometries and designs. Its feasibility design pharmaceutical very promising for making quick prototypes because it flexible does not require expensive equipment or molds. However, development multi-functional drug delivery systems, specifically as solid loaded nanopharmaceuticals, has received recent years, although challenging formulators to convert them into a successful form. The combination nanotechnology field provided platform overcome challenges associated nanomedicine-based forms. Therefore, major focus present manuscript review research developments that involved formulation utilizing technology. Utilization techniques nanopharmaceuticals achieved transformation liquid polymeric nanocapsules self-nanoemulsifying systems (SNEDDS) such tablets suppositories easily customized doses per needs individual patient (personalized medicine). Furthermore, also highlights utility extrusion-based (Pressure-Assisted Microsyringe—PAM; Fused Deposition Modeling—FDM) produce containing nanocapsule SNEDDS oral rectal administration. critically analyzes contemporary related impact process parameters performance

Язык: Английский

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Developing an innovative 3D printing platform for production of personalised medicines in a hospital for the OPERA clinical trial

International Journal of Pharmaceutics, Год журнала: 2024, Номер 661, С. 124306 - 124306

Опубликована: Июнь 12, 2024

Breast cancer is the most frequently diagnosed in women worldwide, and non-adherence to adjuvant hormonotherapy can negatively impact recurrence relapse. Non-adherence associated with side effects of hormonotherapy. Pharmacological strategies mitigate include coadministration antidepressants, however patients remain non-adherent. The aim this work was develop medicines containing both hormonotherapy, tamoxifen (20 mg), along anti-depressants, either venlafaxine (37.5 or 75 mg) duloxetine (30 60 assess acceptability efficacy personalised approach for mitigating a clinical trial. A major criterion developed production rate, specified at minimum 200 dosage units per hour produce more than 40,000 required novel capsule filling enabled by pharmaceutical 3D printer M3DIMAKER 2 purpose. Firstly, semi-solid extrusion printing pharma-ink prepared according French compounding regulation, followed commercial pellets development an innovative pellet dispensing printhead. were successfully produced pharmacy department hospital Gustave Roussy, located Paris, France. satisfied quality rate requirements stable storage up one year cover duration This demonstrates feasibility developing producing combined setting through enable trial high requirement.

Язык: Английский

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3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release

Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(12), С. 3385 - 3403

Опубликована: Янв. 7, 2024

Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, proposes novel approach loading drugs into 3DPS employing first time post-printing loading. Thus, passive strategy molecular models is developed, demonstrating versatility capacity load molecules different charges sizes within matrix systems. This allows adapting wide range single ink, which simplifies speeds up technological development process with physico-chemical properties. Additionally, research, displacement three-dimensional Laponite matrices developed order enhance drug release through their disintegration capacity, resulting significant improvement diffusion hydrogel rapid Finally, our demonstrates that obtained vivo behavior, being non-obstructive allowing normal motility rats intestine.

Язык: Английский

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3D printing of pharmaceutical dosage forms: Recent advances and applications

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115504 - 115504

Опубликована: Дек. 1, 2024

Язык: Английский

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Drug delivery and testing via 3D printing

Bioprinting, Год журнала: 2023, Номер 36, С. e00298 - e00298

Опубликована: Июль 27, 2023

Язык: Английский

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Advancing personalized medicine with 3D printed combination drug therapies: A comprehensive review of application in various conditions

European Polymer Journal, Год журнала: 2024, Номер 215, С. 113245 - 113245

Опубликована: Июнь 18, 2024

Язык: Английский

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Advancements in Colon-Targeted Drug Delivery: A Comprehensive Review on Recent Techniques with Emphasis on Hot-Melt Extrusion and 3D Printing Technologies

AAPS PharmSciTech, Год журнала: 2024, Номер 25(7)

Опубликована: Окт. 8, 2024

Abstract This review investigates the progression and effectiveness of colon-targeted drug delivery systems, offering a comprehensive understanding colon's anatomy physiological environment. Recognizing distinctive features colon is crucial for successfully formulating oral dosage forms that precisely target specific areas in gastrointestinal tract (GIT) while minimizing side effects through mitigating off-target sites. basis designing effective targeted systems. The article extensively examines diverse approaches to drugs colonic targeting, highlighting key polymers excipients their production. Special emphasis given innovative such as hot-melt extrusion (HME) three-dimensional printing (3D-P), renowned accuracy release kinetics intricate form geometry. However, challenges arise regarding material standardization complex network regulatory clearances required confirm safety effectiveness. provides insights into each application’s advantages potential challenges. Furthermore, it sheds light on local diseases necessitate targeting available marketed products, providing an overview current state Additionally, emphasizes importance testing controlled vitro environment during development phase. It also discusses future directions successful this field. By integrating knowledge across anatomy, formulation techniques, assessment methodologies, valuable resource researchers navigating dynamic field delivery. Graphical

Язык: Английский

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Folic acid grafted Tofacitinib loaded targeted Transfersomes for Transdermal delivery against Breast cancer.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106711 - 106711

Опубликована: Фев. 1, 2025

Язык: Английский

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Aplicación de la tecnología de impresión en 3D para la formulación farmacéutica de flavonoides

Ars Pharmaceutica (Internet), Год журнала: 2025, Номер 66(2), С. 247 - 259

Опубликована: Март 19, 2025

Introducción: La impresión en 3D es una tecnología vanguardista que puede emplearse para formular compuestos farmacéuticos de baja solubilidad, como lo son los flavonoides, origen vegetal a cuales se les ha atribuido diversos efectos farmacológicos. Esta revisión describe estudios aplicado esta flavonoides distintas formas farmacéuticas. Método: Se realizó bibliográfica buscando la base datos Google Scholar y el motor búsqueda Pubmed hasta mes enero del año 2025 empleando las palabras clave “3D printing”, “flavonoids” “formulation”. seleccionaron artículos originales publicados idioma inglés. Resultados: encontraron 5 artículos. En ellos, formularon puerarin, catequina, apigenina quercetina. un flavonoide con cardiovasculares formuló tabletas flotantes gástricas extendieron su tiempo permanencia estómago mejoraron liberación comparación convencionales. Para catequina apigenina, (flavonoides propiedades antioxidantes anticancerígenas, respectivamente) diseñaron películas orales mucoadhesivas permiten absorción local rápida tratamiento úlceras leucoplasia, respectivamente. quercetina, actividad antimicrobiana contra Mycobacterium tuberculosis, parches dérmicos lograron liberar fármaco forma sostenida durante 70 h in vitro mantuvieron niveles plasmáticos estables por 18 días modelos animales. Conclusión: empleado exitosamente diferentes farmacéuticas, cual mejorado notablemente sus características biofarmacéuticas. Sin embargo, trata investigación básica, importante llevar cabo ensayos preclínicos manera formal estos productos beneficien pacientes reales, incluyendo veterinarios.

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