Clinical Medicine Insights Case Reports, Год журнала: 2024, Номер 17
Опубликована: Янв. 1, 2024
Intra-parotid metastasis refers to the spread of cancerous cells from a primary tumor lymph nodes within parotid gland. To our best knowledge, we report first described case in literature patient who received IMRT for nasopharyngeal carcinoma (UCNT) without sparing gland and still experienced recurrence.
Язык: Английский
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Янв. 30, 2024
Hypoxia is a common feature of solid tumours affecting their biology and response to therapy. One the main transcription factors activated by hypoxia hypoxia-inducible factor (HIF), which regulates expression genes involved in various aspects tumourigenesis including proliferative capacity, angiogenesis, immune evasion, metabolic reprogramming, extracellular matrix (ECM) remodelling, cell migration. This can negatively impact patient outcomes inducing therapeutic resistance. The importance clearly demonstrated continued research into finding clinically relevant biomarkers, hypoxia-targeting therapies. problems lack applicable methods detection, standardisation. Additionally, lot detecting do not take consideration complexity hypoxic tumour microenvironment (TME). Therefore, this needs further elucidation as approximately 50% are hypoxic. ECM important component TME, developed both cancer associated fibroblasts (CAFs) cells. However, it distinguish different roles develop biomarkers novel compounds. Fibronectin (FN), collagen (COL) hyaluronic acid (HA) components that create fibres. These fibres crosslinked specific enzymes lysyl oxidase (LOX) stiffness induces fibrosis. partially regulated HIFs. review highlights understanding role current data shows contradictory results on also indicates needed identifying CAF subtypes exact roles; with some showing pro-tumorigenic capacity others having anti-tumorigenic roles. has made difficult fully elucidate CAFs within TME. clear an area requires unravelling strategies target have resulted worsened prognosis. cells discussed been modulating environment. Which led development immunotherapies PD-L1. hypoxia-induced changes confer resistance conventional therapies, such chemotherapy, radiotherapy, immunotherapy. summarizes knowledge TME its implications for therapy It discusses potential prognostic predictive indictors treatment response, well challenges opportunities targeting clinical trials.
Язык: Английский
Процитировано
27
Cancers, Год журнала: 2024, Номер 16(6), С. 1206 - 1206
Опубликована: Март 19, 2024
Radiotherapy, a crucial technique in cancer therapy, has traditionally relied on the premise of largely unchanging patient anatomy during treatment course and encompassing uncertainties by target margins. This review introduces adaptive radiotherapy (ART), notable innovation that addresses changes optimizes therapeutic ratio. ART utilizes advanced imaging techniques such as CT, MRI, PET to modify plan based observed anatomical even biological treatment. The narrative provides comprehensive guide for healthcare professionals trainees radiation oncology anyone else interested topic. incorporation artificial intelligence played role improving effectiveness, particularly contour segmentation, planning, quality assurance. expedited process render online feasible, lowered burden practitioners, enhanced precision dynamically personalized Current technical clinical progress is discussed this review, highlighting ongoing development technologies AI emphasizing their contribution enhancing applicability effectiveness ART.
Язык: Английский
Процитировано
23
Archivos de Bronconeumología, Год журнала: 2024, Номер 60, С. S46 - S58
Опубликована: Май 6, 2024
Язык: Английский
Процитировано
7
iScience, Год журнала: 2024, Номер 27(9), С. 110710 - 110710
Опубликована: Авг. 13, 2024
Mitochondria play important roles in cell fate, calcium signaling, mitophagy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a organelle communicate with other organelles to constitute mitochondrial information processing system (MIPS) that transduce input-to-output biological information. The success immunotherapy, concept of systemic therapy, has been proved be dependent on paracrine interactions within tumor microenvironment (TME) distant organs including microbiota immune components. We will adopt broader view from TME micro- macroenvironment (T
Язык: Английский
Процитировано
6
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Фев. 24, 2024
The human protein-coding gene ITGB1 (Integrin 1), also known as CD29, has a length of 58048 base pairs. Integrin family's most prevalent subunit, it participates in the transmission numerous intracellular signaling pathways. A thorough examination ITGB1's functions malignancies, however, is inadequate and many their relationships to onset development cancers remain unknown. In this work, we examined role 33 cancers. Finally, multi-platform analysis revealed that three malignancies had significantly altered expression tumor tissues comparison normal tissues. addition, was discovered through survival stand-alone prognostic factor number linked immune cell infiltration colon cancer, according an investigation pan-cancer. co-expression research, showed positive connection with majority proliferation EMT indicators, indicating may have essential function controlling cancer metastasis proliferation. Our pan-cancer gives evidence favor further into its oncogenic various types.
Язык: Английский
Процитировано
4
BMC Cancer, Год журнала: 2024, Номер 24(1)
Опубликована: Май 3, 2024
Abstract Radiotherapy is a mainstay of cancer treatment. The clinical response to radiotherapy heterogeneous, from complete early progression. Recent studies have explored the importance patient characteristics in radiotherapy. In this editorial, we invite contributions for BMC Cancer collection articles titled ‘Advances personalized radiotherapy’ towards improvement treatment response.
Язык: Английский
Процитировано
4
Cancer Treatment Reviews, Год журнала: 2024, Номер 129, С. 102799 - 102799
Опубликована: Июль 4, 2024
Over half of patients with cancer receive radiation therapy during the course their disease. Decades radiobiological research have identified 6 parameters affecting biological response to referred as "Rs": Repair, Radiosensitivity, Repopulation, Redistribution, Reoxygenation, and Reactivation anti-tumour immune response. Extracellular Vesicles (EVs) are small membrane-bound particles whose multiple functions increasingly documented. Here we discuss evidence for a role EVs in orchestration cells radiotherapy. We highlight that involved DNA repair mechanisms, modulation cellular sensitivity radiation, facilitation tumour repopulation. Moreover, influence reoxygenation dynamics, play pivotal fostering radioresistance. Last, examine how EV-related strategies could be translated into novel aimed at enhancing efficacy against cancer.
Язык: Английский
Процитировано
4
Seminars in Cancer Biology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189315 - 189315
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Oral Oncology, Год журнала: 2024, Номер 158, С. 106982 - 106982
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
3