Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy

Journal of Controlled Release, Год журнала: 2023, Номер 362, С. 19 - 43

Опубликована: Авг. 24, 2023

Язык: Английский

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Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

Nanoscale, Год журнала: 2024, Номер 16(9), С. 4434 - 4483

Опубликована: Янв. 1, 2024

Metal-organic frameworks have become promising stimuli-responsive agents to release the loaded therapeutic in target site achieve more precise drug delivery due their high loading, excellent biocompatibility, and stimuli-responsiveness.

Язык: Английский

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Advances in the variations and biomedical applications of stimuli-responsive nanodrug delivery systems

Nanotechnology, Год журнала: 2024, Номер 35(13), С. 132001 - 132001

Опубликована: Янв. 10, 2024

Abstract Chemotherapy is an important cancer treatment modality, but the clinical utility of chemotherapeutics limited by their toxic side effects, inadequate distribution and insufficient intracellular concentrations. Nanodrug delivery systems (NDDSs) have shown significant advantages in diagnosis treatment. Variable NDDSs that respond to endogenous exogenous triggers attracted much research interest. Here, we summarized nanomaterials commonly used for tumor therapy, such as peptides, liposomes, carbon nanotubes, well responses pH, enzymes, magnetic fields, light, multiple stimuli. Specifically, well-designed can change size or morphology rupture when induced one more The varying stimulation contribute molecular design development novel NDDSs, providing new ideas improving drug penetration accumulation, inhibiting resistance metastasis, enhancing immunotherapy.

Язык: Английский

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A comprehensive review of anti-cancer mechanisms of polyphenol honokiol and nano carrier-based approaches to enhance its therapeutic potential

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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A computer-aided, heterodimer-based “triadic” carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 677, С. 523 - 540

Опубликована: Авг. 14, 2024

Язык: Английский

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Bifunctional drug delivery system with carbonic anhydrase IX targeting and glutathione-responsivity driven by host-guest amphiphiles for effective tumor therapy

Carbohydrate Polymers, Год журнала: 2023, Номер 326, С. 121577 - 121577

Опубликована: Ноя. 14, 2023

Язык: Английский

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Folic Acid-Conjugated UIO-66-MOF Enhances the Targeted Co-Delivery of Cisplatin and Cyclophosphamide for Breast Cancer Therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106510 - 106510

Опубликована: Дек. 1, 2024

Язык: Английский

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Nano pharmaceutical delivery in combating colorectal cancer

Medicine in Drug Discovery, Год журнала: 2023, Номер 21, С. 100173 - 100173

Опубликована: Ноя. 29, 2023

Colorectal cancer (CRC), ranking as the third most common globally, is associated with a high death rate. The colon, also known large intestine, site where colorectal initially develops. It lengthy tube that facilitates passage of digested food to rectum and ultimately out body. CRC has potential affect other organs or regions body if not diagnosed treated earlier. Delivering precise medications in site-specific target-oriented manner can improve chronic disease therapy various ways. In recent years, there have been number innovations nanomedicine (including chemotherapeutic medicines, biological agents, immunotherapeutic such applications) for treatment diseases, including CRC. current review provides an up-to-date overview latest advancements field nanomedicines nano-based drug delivery systems treatment. An in-depth investigation conducted into study nanomaterials liposomes, metal, polymeric peptides nanomaterials, exploring their applications enhancing efficacy both new existing drugs. This focuses on opportunities challenges posed by delivering drugs derived from natural synthetic sources. Additionally, information future prospects provided.

Язык: Английский

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Assessment of the Photosynthetic Response of Potato Plants Inoculated with Rhizoctonia solani and Treated with Flesh-Colored Potato Extracts Nanoencapsulated with Solid Lipid Nanoparticles

Plants, Год журнала: 2025, Номер 14(2), С. 156 - 156

Опубликована: Янв. 7, 2025

Potato has great nutritional and economic importance in agriculture. However, Rhizoctonia solani represents a significant risk, reducing the yield quality of potato production. Flesh-colored (FCP) extracts show vitro inhibitory effects against R. solani, although environmental factors may reduce their stability. Solid lipid nanoparticles (SNLs) offer solution by encapsulating these compounds, preventing degradation, improving delivery, positioning solid as promising technology for sustainable extract application. A greenhouse assay at two phenological stages under inoculation was used to evaluate photosynthetic response (photosynthetic parameters pigments) doses nanoencapsulated (SNL + FCP). During commercial fungicide application, stomatal conductance, rate, internal CO2 concentration increased compared with those non-inoculated control (NT), whereas maintained levels similar NT, suggesting possible regulation defense system. In terms pigments, SLN FCP chlorophyll concentrations, unlike inoculated plants, which significantly decreased. Component analysis revealed that lower dose primarily B synthesis, higher control. These findings suggest an improved from fungicides, particularly respect pigments. further research is needed, results indicate potential eco-friendly phytopathogenic fungi

Язык: Английский

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A computer-aided, carrier-free drug delivery system with enhanced cytotoxicity and biocompatibility: a universal model for multifunctional lung cancer therapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114557 - 114557

Опубликована: Фев. 9, 2025

Язык: Английский

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