Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(6), С. 188984 - 188984
Опубликована: Сен. 16, 2023
Язык: Английский
Cancer Cell International, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 18, 2024
Abstract One of the key features cancer is energy metabolic reprogramming which tightly related to proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class RNAs having no protein-coding potential mainly include microRNAs, lncRNAs circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating reprogramming, altered networks mediated by primarily drive carcinogenesis expression enzymes transporter proteins. Importantly, accumulated research revealed dysregulated mediate contributing generation therapeutic tolerance. Elucidating molecular mechanism can provide promising metabolism-related targets for treatment as well overcome In conclusion, this review updates latest mechanisms reprogramming.
Язык: Английский
Процитировано
10
Frontiers in Genetics, Год журнала: 2025, Номер 15
Опубликована: Янв. 14, 2025
Background Neoadjuvant, endocrine, and targeted therapies have significantly improved the prognosis of breast cancer (BC). However, due to high heterogeneity cancer, some patients cannot benefit from existing treatments. Increasing evidence suggests that amino acids their metabolites can alter tumor malignant behavior through reshaping microenvironment regulation immune cell function. Breast lines been identified as methionine-dependent, methionine restriction has proposed a potential treatment strategy. Methods We integrated transcriptomic single-cell RNA sequencing (ScRNA-seq) analyses based on The Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) datasets. Then we applied weighted gene co-expression network analysis (WGCNA) Cox regression evaluate metabolism-related genes (MRGs) in BC, constructing validating prognostic model for BC patients. Immune landscapes immunotherapy were further explored. Finally, vitro experiments conducted assess expression function key APOC1. Results In this study, established validated signature eight methionine-related predict overall survival (OS) Patients stratified into high-risk low-risk groups according risk score. Further revealed significant differences between two terms pathway alterations, characteristics, checkpoint expression. Our study shed light relationship metabolism infiltration BC. APOC1, signature, was found be upregulated closely associated with infiltration. Notably, APOC1 primarily expressed macrophages. Subsequent demonstrated silencing reduced generation tumor-associated macrophages (TAMs) an M2 phenotype while decreasing proliferation, invasion, migration MDA-MB-231 MDA-MB-468 lines. Conclusion score consisting metabolism, which helps response regulating macrophage polarization
Язык: Английский
Процитировано
1
British Journal of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Inflammatory bowel disease (IBD) is closely associated with immune dysfunction, where nutrient-mediated metabolic flux dictates cell fate and function. Thiamine a central water-soluble vitamin involved in cellular energy metabolism, its deficiency has been reported IBD patients. However, whether thiamine cause or consequence of pathogenesis remains unclear. The current study aimed to reveal the immunometabolic regulation macrophages underlying mechanism colitis development. was induced C57BL/6 mice bone marrow-derived (BMDMs), by administering thiamine-deficient diet/medium together pyrithiamine hydrobromide. frequency macrophage phenotypes their intracellular metabolism were detected using flow cytometry non-targeted metabolomics, respectively. aggravated ulcerative promoted infiltration proinflammatory M1 colonic lamina propria. Our mechanistic revealed that impaired pyruvate dehydrogenase (PDH) activity, thereby reprogramming glucose enhance glycolysis lactic acid accumulation macrophages. Using well-established PDH inhibitor (CPI-613) (galloflavin), we further demonstrated inhibition mimics, while lactate partially rescues, deficiency-induced experimental mice. provides evidence linking activation aggravation, suggesting monitoring status adjusting intake necessary protect against colitis.
Язык: Английский
Процитировано
1
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер 209, С. 104683 - 104683
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
1
Nature Aging, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
1
Pharmacological Research, Год журнала: 2023, Номер 199, С. 107022 - 107022
Опубликована: Дек. 1, 2023
Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches
Язык: Английский
Процитировано
19
Clinical and Translational Medicine, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 1, 2024
Abstract Background One‐carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, series of nutrients are used to fuel pathways, including nucleotide amino acid cellular redox defence and epigenetic maintenance. At present, considered the hallmark cancer. The units obtained from pathways increase proliferation rate cancer cells. addition, anticancer drugs, such as methotrexate, which target have long been clinic. terms immunotherapy, has explore biomarkers connected with immunotherapy response immune‐related adverse events patients. Methods We collected numerous literatures explain one‐carbon immunotherapy. Results this review, we focus on important function enzymes Then, summarise inhibitors acting their potential application Finally, provide viewpoint conclusion regarding opportunities challenges targeting for clinical practicability future. Conclusion Targeting useful
Язык: Английский
Процитировано
8
Cell Metabolism, Год журнала: 2024, Номер 36(11), С. 2449 - 2467.e6
Опубликована: Окт. 28, 2024
Язык: Английский
Процитировано
8
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Сен. 18, 2024
Язык: Английский
Процитировано
7
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 7, 2025
The cGAS-STING signaling pathway serves as a critical link between DNA sensing and innate immunity, has tremendous potential to improve anti-tumor immunity by generating type I interferons. However, STING agonists have shown decreasing biotherapeutic efficacy in clinical trials. Tumor metabolism, characterized aberrant nutrient utilization energy production, is fundamental hallmark of tumorigenesis. And modulating metabolic pathways tumor cells been discovered therapeutic strategy for tumors. As research concerning progressed, emerging evidence highlights its role reprogramming, independent immune function, indicating targets activation cancers. In this review, we delve into the interplay multiple pathways. We also synthesize current knowledge on antitumor functions STING, within microenvironment (TME) that could be exploited activation. This review necessity future dissect complex interactions with various cancer types, emphasizing personalized strategies based profiling.
Язык: Английский
Процитировано
1