Cited by Tryptophan metabolism regulates inflammatory macrophage polarization as a predictive factor for breast cancer immunotherapy

Targeting macrophages in cancer immunotherapy: Frontiers and challenges DOI

Yue Liu, Huabing Tan, Jingyuan Dai

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and checkpoint blockade. Nevertheless, cells encounters formidable hurdles. Macrophages, serving pivotal link between innate adaptive immunity, play crucial roles phagocytosis, cytokine secretion, antigen presentation. Consequently, macrophage-targeted therapies have garnered significant attention. We aim to provide most cutting-edge insights future perspectives for therapies, fostering development novel effective treatments. To date, forefront strategies macrophage targeting encompass: altering their plasticity, harnessing CAR-macrophages, phagocytosis checkpoints. Macrophages are characterized by remarkable diversity offering unique therapeutic target. In this context, we critically analyze innovative aimed at transforming macrophages from M2 (tumor-promoting) M1 (tumor-suppressing) phenotype. Furthermore, delve into design principles, developmental progress, advantages CAR-macrophages. Additionally, illuminate challenges encountered checkpoints on propose potential overcome these obstacles.

Language: Английский

Citations

Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages DOI

Xiaohua Pan,

Zhengnan Ren, Wenjie Liang

et al.

British Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Inflammatory bowel disease (IBD) is closely associated with immune dysfunction, where nutrient-mediated metabolic flux dictates cell fate and function. Thiamine a central water-soluble vitamin involved in cellular energy metabolism, its deficiency has been reported IBD patients. However, whether thiamine cause or consequence of pathogenesis remains unclear. The current study aimed to reveal the immunometabolic regulation macrophages underlying mechanism colitis development. was induced C57BL/6 mice bone marrow-derived (BMDMs), by administering thiamine-deficient diet/medium together pyrithiamine hydrobromide. frequency macrophage phenotypes their intracellular metabolism were detected using flow cytometry non-targeted metabolomics, respectively. aggravated ulcerative promoted infiltration proinflammatory M1 colonic lamina propria. Our mechanistic revealed that impaired pyruvate dehydrogenase (PDH) activity, thereby reprogramming glucose enhance glycolysis lactic acid accumulation macrophages. Using well-established PDH inhibitor (CPI-613) (galloflavin), we further demonstrated inhibition mimics, while lactate partially rescues, deficiency-induced experimental mice. provides evidence linking activation aggravation, suggesting monitoring status adjusting intake necessary protect against colitis.

Language: Английский

Citations

Resistance to PD-1/PD-L1 immune checkpoint blockade in advanced non-small cell lung cancer DOI

Lijun Li,

Haihong Pu,

Xiaoxin Zhang

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 209, P. 104683 - 104683

Published: Feb. 28, 2025

Language: Английский

Citations

Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer DOI

Yifei Cheng, Bingxin Liu, Junyi Xin

et al.

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

Xi Wang, Yixuan Li,

Xueyu Pu

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107022 - 107022

Published: Dec. 1, 2023

Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches

Language: Английский

Citations

Tumor associated macrophages in esophageal squamous carcinoma: Promising therapeutic implications DOI

Jiale Zhang, Yanxin Dong, Shouyin Di

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115610 - 115610

Published: Sept. 30, 2023

Esophageal squamous carcinoma (ESCC) is a prevalent and highly lethal malignant tumor, with five-year survival rate of approximately 20 %. Tumor-associated macrophages (TAMs) are the most prominent immune cells in tumor microenvironment (TME), comprising over 50 % volume. TAMs can be polarized into two distinct phenotypes, M1-type M2-type, through interactions cancer cells. M2-type more abundant than TME, contributing to progression, such as cell construction an immunosuppressive environment. This review focuses on role ESCC, including their polarization, impact proliferation, angiogenesis, invasion, migration, therapy resistance, immunosuppression. In addition, we discuss potential targeting for clinical ESCC. A thorough comprehension molecular biology about essential development innovative therapeutic strategies treat

Language: Английский

Citations

Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective DOI

Yang Xiao, Yongsheng Li,

Huakan Zhao

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 18, 2024

Language: Английский

Citations

Targeting one‐carbon metabolism for cancer immunotherapy DOI

Xinxin Ren, Xiang Wang, Guowan Zheng

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 1, 2024

Abstract Background One‐carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, series of nutrients are used to fuel pathways, including nucleotide amino acid cellular redox defence and epigenetic maintenance. At present, considered the hallmark cancer. The units obtained from pathways increase proliferation rate cancer cells. addition, anticancer drugs, such as methotrexate, which target have long been clinic. terms immunotherapy, has explore biomarkers connected with immunotherapy response immune‐related adverse events patients. Methods We collected numerous literatures explain one‐carbon immunotherapy. Results this review, we focus on important function enzymes Then, summarise inhibitors acting their potential application Finally, provide viewpoint conclusion regarding opportunities challenges targeting for clinical practicability future. Conclusion Targeting useful

Language: Английский

Citations

Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls DOI

Piyal Saha,

Paul Ettel,

Thomas Weichhart

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(4), P. 335 - 349

Published: March 17, 2024

Tumor-associated macrophages (TAMs) constitute an important part of the tumor microenvironment (TME) that regulates progression. Tumor-derived signals, hypoxia, and competition for nutrients influence TAMs to reprogram their cellular metabolism. This altered metabolic profile creates a symbiotic communication between other immune cells support growth. In addition, expression checkpoint molecules. The dynamic plasticity also allows reshape metabolism in response modern therapeutic strategies. Therefore, over years, significant number approaches have been implicated cancer-promoting TAMs. this review, we discuss current strategies pitfalls, along with upcoming promising opportunities leveraging TAM developing better against cancer.

Language: Английский

Citations

Targeting tumor-associated macrophage: an adjuvant strategy for lung cancer therapy DOI

Lei Liu,

Genwang Chen,

Sisi Gong

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 13, 2023

The emergence of immunotherapy has revolutionized the treatment landscape for various types cancer. Nevertheless, lung cancer remains one leading causes cancer-related mortality worldwide due to development resistance in most patients. As abundant groups immune cells tumor microenvironment (TME), tumor-associated macrophages (TAMs) play crucial and complex roles cancer, including regulation immunosuppressive TME remodeling, metabolic reprogramming, neoangiogenesis, metastasis, promotion tumoral neurogenesis. Hence, relevant strategies therapy, such as inhibition macrophage recruitment, TAM reprograming, depletion TAMs, engineering TAMs drug delivery, have been developed. Based on satisfactory effect TAM-targeted recent studies also investigated its synergistic with current therapies immunotherapy, radiotherapy, chemotherapy, anti-epidermal growth factor receptor (anti-EGFR) treatment, or photodynamic therapy. Thus, this article, we summarized key mechanisms contributing progression elaborated novel therapeutic against TAMs. We discussed potential targeting adjuvant therapy particularly highlighting TAM-centered improving efficacy anti-programmed cell death-1/programmed death-ligand 1 (anti-PD-1/PD-L1) treatment.

Language: Английский

Citations