Nature Immunology, Год журнала: 2024, Номер 25(8), С. 1474 - 1488
Опубликована: Июль 2, 2024
Abstract Natural killer (NK) cells are innate lymphoid (ILCs) contributing to immune responses microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) cellular indexing transcriptomes epitopes by (CITE-seq) dissect the heterogeneity NK cells. We identified three prominent cell subsets in healthy human blood: NK1, NK2 NK3, further differentiated into six distinct subgroups. Our findings delineate molecular characteristics, key transcription factors, biological functions, metabolic traits cytokine each subgroup. These data also suggest two separate ontogenetic origins for cells, leading divergent transcriptional trajectories. Furthermore, analyzed distribution lung, tonsils intraepithelial lymphocytes isolated from individuals 22 tumor types. This standardized terminology aims at fostering clarity consistency future research, thereby improving cross-study comparisons.
Язык: Английский
Процитировано
53Diversity of group 1 innate lymphoid cells in human tissues
Nature Immunology, Год журнала: 2024, Номер 25(8), С. 1460 - 1473
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
8NK resident memory cells arise from NK cells that accumulate in tissues independently of persistent local infection
Immunity, Год журнала: 2025, Номер 58(3), С. 515 - 516
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1Group 1
Immunological Reviews, Год журнала: 2024, Номер 323(1), С. 107 - 117
Опубликована: Апрель 2, 2024
Summary Group 1 innate lymphoid cells (ILCs), comprising ILC1s and natural killer (NK cells), belong to a large family of developmentally related that lack rearranged antigen‐specific receptors. NK both require the transcription factor T‐bet for lineage commitment but additionally rely on Eomes Hobit, respectively, their development effector maturation programs. Both are essential rapid responses against infections mediate cancer immunity through production cytokines cytotoxicity mediators. enriched in tissues hence generally considered tissue resident whereas often circulatory. Despite being deemed different cell types, share many common features phenotypically functionally. Recent studies employing single RNA sequencing (scRNA‐seq) technology have exposed previously unappreciated heterogeneity group ILCs further broaden our understanding these cells. Findings from imply organs signature exhibit some unique characteristics, possibly stemming imprinting. Also, data recent fate mapping RORγt, polychromic reporter mice greatly advanced developmental programs In this review, we aim outline fundamental traits mouse explore discoveries programs, phenotypic heterogeneity, plasticity, transcriptional regulation.
Язык: Английский
Процитировано
6The role of trained immunity in sepsis
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 15, 2024
Sepsis is defined as a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection, characterized systemic inflammatory infection. The use of antibiotics, fluid resuscitation, and support therapy has limited prognostic benefit in patients with sepsis, its incidence not diminishing, which attracting increased attention medicine. remains one the most debilitating expensive illnesses. One main reasons septic mortality now understood be disruption immune homeostasis. Immunotherapy revolutionizing treatment illnesses responses play significant role. This “trained immunity”, potent defense against infection regardless type bacteria, fungus, or virus, attributed discovery that innate cells possess memory via metabolic epigenetic reprogramming. Here we reviewed immunotherapy features trained immunity, relationship between immunity sepsis.
Язык: Английский
Процитировано
5Tissue‐resident memory
Immunological Reviews, Год журнала: 2024, Номер 323(1), С. 54 - 60
Опубликована: Апрель 3, 2024
Summary Natural killer (NK) cells are the prototype innate effector lymphocyte population that plays an important role in controlling viral infections and tumors. Studies demonstrating NK form long‐lived memory populations, akin to those generated by adaptive immune cells, prompted a revaluation of potential functions cells. Recent data recruited from circulation into tissues where they memory‐like populations further emphasize have properties mirror localize non‐lymphoid heterogeneous, there is growing appreciation responses occurring within subject tissue‐specific regulation. Here we discuss both immunoregulatory with particular emphasis on how tissue microenvironment shapes cell‐dependent outcomes.
Язык: Английский
Процитировано
4Metabolic programming of organ‐specific natural killer cell responses
Immunological Reviews, Год журнала: 2024, Номер 323(1), С. 8 - 18
Опубликована: Апрель 17, 2024
Summary Cells of the mammalian innate immune system have evolved to protect host from various environmental or internal insults and injuries which perturb homeostatic state organism. Among lymphocytes are natural killer (NK) cells, circulate survey tissues for signs stress, including infection transformation. NK cells rapidly eliminate damaged in blood within through secretion cytolytic machinery production proinflammatory cytokines. To perform these effector functions while traversing between tissues, patrolling require sufficient fuel meet their energetic demands. Here, we highlight ability metabolically adapt across during times nutrient deprivation tumor microenvironments. Whether at steady state, viral cancer, readily shift uptake usage order maintain metabolism, survival, function.
Язык: Английский
Процитировано
4CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(48)
Опубликована: Ноя. 19, 2024
Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with poorly understood immunopathogenesis. Here, we report that HS lesional characterized by the expansion of innate lymphocytes and T cells expressing CD2, an essential activation receptor adhesion molecule. Lymphocytes elevated CD2 predominated unique spatial distribution throughout epidermis hypodermis in lesion. + were mainly NK cell marker, CD56, CD4 cells. Importantly, these interacted CD58 (LFA3) epidermal keratinocytes fibroblasts hypodermis. Granzyme A bright NKT (CD2 CD3 CD56 ) clustered α-SMA juxtaposed to epithelialized tunnels fibrotic regions Whereas dim perforin , granzymes B enriched adjacent hyperplastic follicular showing presence apoptotic The cytokines IL-12, IL-15, IL-18, which enhance maturation function significantly HS. Ex vivo explant cultures treated CD2:CD58 interaction-blocking anti-CD2 monoclonal antibody attenuated secretion cytokines/chemokines suppressed gene signature. Additionally, blockade altered miRNAs involved NK/NKT differentiation and/or function. In summary, show cellular network heterogenous populations drives inflammation critical pathobiology HS, including tunnel formation fibrosis. Finally, viable immunotherapeutic approach for effective management
Язык: Английский
Процитировано
4Tissue-resident NK cells do their own glandscaping
The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(3)
Опубликована: Янв. 3, 2025
In this issue of JEM, Sparano et al. (https://doi.org/10.1084/jem.20240930) present compelling evidence that salivary gland trNK cells originate from cNK and are developmentally distinct ILC1 cells. Mechanistically, they demonstrate continuous autocrine TGF-β signaling drives tissue residency works in synergy with IL-15 to enhance Hobit-dependent cytotoxicity.
Язык: Английский
Процитировано
0From natural defenders to therapeutic warriors: NK cells in HIV immunotherapy
Immunotherapy, Год журнала: 2025, Номер unknown, С. 1 - 13
Опубликована: Фев. 5, 2025
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells both play essential roles in controlling viral infections by eliminating virus-infected cells. Unlike CTLs, which require priming activation antigen-presenting cells, NK possess a remarkable capacity to mount rapid antiviral immune response immediately after infection. Additionally, they can bolster the adaptive system secreting cytokines directly interacting with other However, during chronic human immunodeficiency virus (HIV) infection, various including experience functional impairments. This has led exploration of cell-based immunotherapy as promising strategy reverse these dysfunctions contribute pursuit cure for HIV. Building on success cell therapies cancer treatment, approaches offer significant potential transforming HIV field. review provides comprehensive overview latest advances HIV, outlining progress made key challenges that must be overcome achieve people living
Язык: Английский
Процитировано
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