International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11379 - 11379
Опубликована: Июль 12, 2023
The
global
rise
of
single-use
throw-away
plastic
products
has
elicited
a
massive
increase
in
the
nano/microplastics
(N/MPLs)
exposure
burden
humans.
Recently,
it
been
demonstrated
that
disposable
period
may
release
N/MPLs
with
usage,
which
represents
potential
threat
to
women's
health
not
scientifically
addressed
yet.
By
using
polyethyl
ene
(PE)
particles
(200
nm
9
μm),
we
showed
acute
high
concentration
induced
cell
toxicity
vaginal
keratinocytes
after
effective
cellular
uptake,
as
viability
and
apoptosis
data
suggest,
along
transmission
electron
microscopy
(TEM)
observations.
internalised
altered
expression
junctional
adherence
proteins
organisation
actin
cortex,
influencing
level
genes
involved
oxidative
stress
signalling
pathways
miRNAs
related
epithelial
barrier
function.
When
PE
was
discontinued
or
became
chronic,
cells
were
able
recover
from
negative
effects
on
differentiation/proliferation
gene
few
days.
However,
all
cases,
N/MPL
prompted
sustained
alteration
DNA
methyltransferase
demethylase
expression,
might
impact
epigenetic
regulation
processes,
leading
accelerated
ageing
inflammation,
occurrence
malignant
transformation.
The Science of The Total Environment,
Год журнала:
2023,
Номер
902, С. 166003 - 166003
Опубликована: Авг. 6, 2023
The
accumulation
of
microplastics
(MPs)
in
the
environment
as
well
their
presence
foods
and
humans
highlight
urgent
need
for
studies
on
effects
these
particles
humans.
Polylactic
acid
(PLA)
is
most
widely
used
bioplastic
food
industry
medical
field.
Despite
its
biodegradability,
biocompatibility,
"Generally
Recognized
As
Safe"
(GRAS)
status,
recent
animal
model
have
shown
that
PLA
MPs
can
alter
intestinal
microbiota;
however,
to
date,
no
been
reported
possible
gut
health
consequences
intake
by
This
work
simulates
ingestion
a
realistic
daily
amount
pass
through
gastrointestinal
tract
combining
INFOGEST
method
simgi®
evaluate
human
colonic
microbiota
composition
(16S
rRNA
gene
sequencing
analysis)
metabolic
functionality
(lactic
short-chain
fatty
acids
(SCFA)
production).
Although
did
not
clearly
microbial
community
homeostasis,
increased
Bifidobacterium
levels
tended
increase
millimetric
particles.
Furthermore,
shifts
detected
at
functional
level
suggest
an
alteration
metabolism,
biotransformation
community.
Raman
spectroscopy
field
emission
scanning
electron
microscopy
(FESEM)
characterization
revealed
morphological
changes
after
gastric
phase
digestion,
adhesion
organic
matter
biofilm,
with
surface
biodegradation,
phases.
With
this
evidence
emerging
use
bioplastics,
understanding
impact
potential
biodegradation
digestion
merits
critical
investigation.
PLoS ONE,
Год журнала:
2024,
Номер
19(1), С. e0296788 - e0296788
Опубликована: Янв. 24, 2024
Bioaccumulation
and
biomagnification
of
anthropogenic
particles
are
crucial
factors
in
assessing
microplastic
impacts
to
marine
ecosystems.
Microplastic
pollution
poses
a
significant
threat
iconic
often
endangered
species
but
examining
their
tissues
gut
contents
for
contaminant
analysis
via
lethal
sampling
is
challenging
due
ethical
concerns
animal
care
restrictions.
Incorporating
empirical
data
from
prey
items
fecal
matter
into
models
can
help
trace
movement
through
food
webs.
In
this
study,
the
Galápagos
penguin
web
served
as
an
indicator
assess
bioaccumulation
potential
using
trophodynamic
Ecopath
with
Ecosim
(EwE)
modelling
Ecotracer.
Empirical
collected
surface
seawater
near
colonies,
zooplankton,
prey,
scat
October
2021
were
used
inform
ecosystem
model.
Multiple
scenarios,
including
99%
elimination
rate,
employed
model
sensitivity.
Model
predictions
revealed
that
microplastics
bioaccumulate
all
predator-prey
relationships,
highly
dependent
on
rate.
It
establishes
need
more
research
rates
different
plastics,
which
critical
missing
gap
current
ecotoxicological
science.
Compared
data,
efforts
underpredicted
concentrations
zooplankton
over-predicted
fish.
Ultimately,
provides
novel
insights
microplastics’
risks.
These
findings
support
regional
plastic
management
conserve
native
endemic
Islands
Marine
Reserve.
Journal of Toxicology and Environmental Health Part B,
Год журнала:
2024,
Номер
27(4), С. 153 - 187
Опубликована: Март 22, 2024
The
widespread
production
and
use
of
plastics
have
resulted
in
accumulation
plastic
debris
the
environment,
gradually
breaking
down
into
smaller
particles
over
time.
Nano-plastics
(NPs)
microplastics
(MPs),
defined
as
than
100
nanometers
5
millimeters,
respectively,
raise
concerns
due
to
their
ability
enter
human
body
through
various
pathways
including
ingestion,
inhalation,
skin
contact.
Various
investigators
demonstrated
that
these
may
produce
physical
chemical
damage
cells,
tissues,
organs,
disrupting
cellular
processes,
triggering
inflammation
oxidative
stress,
impacting
hormone
neurotransmitter
balance.
In
addition,
micro-
nano-plastics
(MNPLs)
carry
toxic
chemicals
pathogens,
exacerbating
adverse
effects
on
health.
magnitude
nature
are
not
yet
fully
understood,
requiring
further
research
for
a
comprehensive
risk
assessment.
Nevertheless,
evidence
available
suggests
environment
potential
uptake
causes
concern.
Urgent
measures
reduce
pollution
limit
exposure
MNPLs
necessary
safeguard
health
environment.
this
review,
current
knowledge
regarding
influence
is
summarized,
toxicity
mechanisms,
pathways,
outcomes
across
multiple
organs.
critical
need
additional
also
emphasized
comprehensively
assess
risks
posed
by
degradation
inform
strategies
addressing
emerging
environmental
challenge.
Finally,
new
directions
proposed
evaluation
gene
regulation
associated
with
exposure.
Cancers,
Год журнала:
2024,
Номер
16(21), С. 3703 - 3703
Опубликована: Ноя. 1, 2024
Humans
cannot
avoid
plastic
exposure
due
to
its
ubiquitous
presence
in
the
natural
environment.
The
waste
generated
is
poorly
biodegradable
and
exists
form
of
MPs,
which
can
enter
human
body
primarily
through
digestive
tract,
respiratory
or
damaged
skin
accumulate
various
tissues
by
crossing
biological
membrane
barriers.
There
an
increasing
amount
research
on
health
effects
MPs.
Most
literature
reports
focus
impact
plastics
respiratory,
digestive,
reproductive,
hormonal,
nervous,
immune
systems,
as
well
metabolic
MPs
accumulation
leading
epidemics
obesity,
diabetes,
hypertension,
non-alcoholic
fatty
liver
disease.
xenobiotics,
undergo
ADMET
processes
body,
i.e.,
absorption,
distribution,
metabolism,
excretion,
are
not
fully
understood.
Of
particular
concern
carcinogenic
chemicals
added
during
manufacturing
adsorbed
from
environment,
such
chlorinated
paraffins,
phthalates,
phenols,
bisphenols,
be
released
when
absorbed
body.
continuous
increase
NMP
has
accelerated
SARS-CoV-2
pandemic
there
was
a
need
use
single-use
products
daily
life.
Therefore,
urgent
diagnose
problems
related
MP
detection.
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
471, С. 134253 - 134253
Опубликована: Апрель 11, 2024
Micro-
and
nanoplastics
(MNPs)
are
ubiquitous
in
the
environment,
resulting
uptake
of
MNPs
by
a
variety
organisms,
including
humans,
leading
to
particle-cell
interaction.
Human
macrophages
derived
from
THP-1
cell
lines
take
up
Polystyrene
(PS),
widespread
plastic.
The
question
therefore
arises
whether
primary
human
also
PS
micro-
nanobeads
(MNBs)
how
they
react
this
stimulation.
Major
aim
study
is
visualize
validate
isolation
peripheral
blood
mononuclear
cells
(PBMCs)
assess
impact
on
macrophages.
Uptake
PBMCs
was
examined
transmission
electron
microscopy
(TEM),
scanning
live
imaging.
In
addition,
reaction
analyzed
terms
metabolic
activity,
cytotoxicity,
production
reactive
oxygen
species
(ROS)
macrophage
polarization.
This
first
MNBs
using
TEM
Metabolic
activity
size-
concentration-dependent,
necrosis
ROS
were
increased.
methods
demonstrated
outline
an
approach
influence
MNP
exposure
help
investigating
consequences
worldwide
plastic
pollution.
among
particles
which
can
be
found
different
ecosystems
(1).
Because
their
size,
enter
food
chain
accumulate
large
organisms
(2).
Previous
studies
already
showed
cytotoxic
effect
murine
dTHP-1
(3,
4).
However
more
research
needed
distribution
humans.
Studying
potential
health
risks
model,
supports
process
political
decision-making
addressing
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(21), С. 9071 - 9081
Опубликована: Май 15, 2024
Little
research
exists
on
the
magnitude,
variability,
and
uncertainty
of
human
exposure
to
airborne
micro-
nanoplastics
(AMNPs),
despite
their
critical
role
in
MNPs.
We
probabilistically
estimate
global
intake
AMNPs
through
three
main
pathways:
indoor
inhalation,
outdoor
ingestion
during
meals,
for
both
children
adults.
The
median
inhalation
AMPs
is
1,207.7
(90%
CI,
42.5–8.48
×
104)
1,354.7
47.4–9.55
N/capita/day
adults,
respectively.
annual
13.18
mg/capita/a
19.10
which
approximately
one-fifth
one-third
mass
a
standard
stamp,
assuming
consistent
daily
medians.
majority
AMP
number
occurs
while
deposited
meals
contributes
most
terms
mass.
Furthermore,
ANP
9,638.1
N/day
(8.23
10–6
μg/d)
5,410.6
(4.62
respectively,
compared
5.30
105
(5.79
10–4
6.00
(6.55
via
inhalation.
Considering
increased
toxicity
smaller
MNPs,
significant
ANPs
inhaled
warrants
great
attention.
Collaborative
efforts
are
imperative
further
elucidate
combat
current
MPN
risks.
The Science of The Total Environment,
Год журнала:
2024,
Номер
949, С. 174881 - 174881
Опубликована: Июль 22, 2024
The
ubiquitous
and
global
ecological
footprint
arising
from
the
rapidly
increasing
rates
of
plastic
production,
use,
release
into
environment
is
an
important
modern
environmental
issue.
Of
concern
are
risks
associated
with
at
least
16,000
chemicals
present
in
plastics,
some
which
known
to
be
toxic,
may
leach
out
both
during
use
once
exposed
conditions,
leading
human
exposure.
In
response,
United
Nations
member
states
agreed
establish
international
legally
binding
instrument
on
pollution,
plastics
treaty.
resolution
acknowledges
that
treaty
should
prevent
pollution
its
related
impacts,
effective
prevention
requires
consideration
transboundary
nature
full
life
cycle
must
addressed.
As
a
group
scientific
experts
members
Scientists'
Coalition
for
Effective
Plastics
Treaty,
we
concur
there
six
essential
"pillars"
necessary
truly
reduce
allow
chemical
detoxification
across
plastics.
These
include
reduction
simplification,
safe
sustainable
design
chemicals,
incentives
change,
holistic
approaches
alternatives,
just
transition
equitable
interventions,
centering
rights.
There
critical
need
scientifically
informed
globally
harmonized
information,
transparency,
traceability
criteria
protect
public
health.
right
clean,
healthy,
upheld,
thus
it
crucial
scientists,
industry,
policy
makers
work
concert
create
future
free
hazardous
contamination.