Assessing the Impact of Polyethylene Nano/Microplastic Exposure on Human Vaginal Keratinocytes DOI Open Access
Paola Pontecorvi, Simona Ceccarelli,

Fabrizio Cece

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11379 - 11379

Опубликована: Июль 12, 2023

The global rise of single-use throw-away plastic products has elicited a massive increase in the nano/microplastics (N/MPLs) exposure burden humans. Recently, it been demonstrated that disposable period may release N/MPLs with usage, which represents potential threat to women's health not scientifically addressed yet. By using polyethyl ene (PE) particles (200 nm 9 μm), we showed acute high concentration induced cell toxicity vaginal keratinocytes after effective cellular uptake, as viability and apoptosis data suggest, along transmission electron microscopy (TEM) observations. internalised altered expression junctional adherence proteins organisation actin cortex, influencing level genes involved oxidative stress signalling pathways miRNAs related epithelial barrier function. When PE was discontinued or became chronic, cells were able recover from negative effects on differentiation/proliferation gene few days. However, all cases, N/MPL prompted sustained alteration DNA methyltransferase demethylase expression, might impact epigenetic regulation processes, leading accelerated ageing inflammation, occurrence malignant transformation.

Язык: Английский

A Call to Include Plastics in the Global Environment in the Class of Persistent, Bioaccumulative, and Toxic (PBT) Pollutants DOI Open Access
Juan José Alava, Annika Jahnke, Melanie Bergmann

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(22), С. 8185 - 8188

Опубликована: Май 22, 2023

ADVERTISEMENT RETURN TO ISSUEViewpointNEXTA Call to Include Plastics in the Global Environment Class of Persistent, Bioaccumulative, and Toxic (PBT) PollutantsJuan José Alava*Juan AlavaOcean Pollution Research Unit & Nippon Foundation-Ocean Litter Project, Institute for Oceans Fisheries, University British Columbia, AERL 2202 Main Mall, Vancouver V6T 1Z4, BC, CanadaSchool Resource Environmental Management, Simon Fraser University, 8888 Drive, Burnaby V5A 1S6, Canada*[email protected]More by Juan AlavaView Biographyhttps://orcid.org/0000-0002-6312-7776, Annika JahnkeAnnika JahnkeDepartment Ecological Chemistry, Helmholtz Centre Research−UFZ, Permoserstr. 15, Leipzig DE-04318, GermanyInstitute Research, RWTH Aachen DE-52074, GermanyMore Jahnke, Melanie BergmannMelanie BergmannAlfred-Wegener-Institute Helmholtz-Zentrum für Polar- und Meeresforschung, Bremerhaven DE-16227570, Bergmannhttps://orcid.org/0000-0001-5212-9808, Gabriela V. Aguirre-MartínezGabriela Aguirre-MartínezQuímica y Farmacia. Facultad de Ciencias la Salud, Universidad Arturo Prat, Avenida Prat Chacón, Iquique 2120, ChileMore Aguirre-Martínez, Leah BendellLeah BendellDepartment Biological Sciences, CanadaMore Bendell, Paola CallePaola CalleFacultad Vida, ESPOL Polytechnic Escuela Superior Politécnica del Litoral, ESPOL, Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863, Guayaquil 00000, EcuadorMore Calle, A. DomínguezGustavo DomínguezFacultad Domínguez, Elaine M. FaustmanElaine FaustmanInstitute Risk Analysis Communication, Department Occupational Health Washington, 4225 Roosevelt Way NE, Suite #100, Seattle 98105, United StatesMore Faustman, Jill FalmanJill FalmanInstitute Falman, Tamara N. KazmirukTamara KazmirukDepartment Kazmiruk, Natasha KlasiosNatasha KlasiosDepartment Zoology, Klasioshttps://orcid.org/0000-0002-7527-6090, Maria T. MaldonadoMaria MaldonadoEarth, Ocean Atmospheric 2207 BC Maldonado, Karly McMullenKarly McMullenOcean McMullen, Marcia Moreno-BáezMarcia Moreno-BáezThe Fletcher School/Tufts Technology Services, Tufts 35 Lower Rd, Medford 02155, Massachusetts, Moreno-Báez, Gunilla ÖbergGunilla ÖbergInstitute Resources, Sustainability, Öberg, Yoshitaka OtaYoshitaka OtaNippon Foundation Nexus Center, School Marine Affairs EarthLab, 355674, 98195-5674, Ota, Dana PriceDana PriceOcean Price, Won Joon ShimWon ShimKorea Science (KIOST), Geoje 53201, Republic KoreaUniversity Technology, Daejeon, 34113, South KoreaMore Shim, Ana TirapéAna TirapéFacultad Tirapé, Jessica VandenbergJessica VandenbergNippon Vandenberg, Zeinab ZoveidadianpourZeinab ZoveidadianpourOcean CanadaDepartment Zoveidadianpour, Judith WeisJudith WeisDepartment Rutgers Newark 07102, New Jersey, WeisCite this: Environ. Sci. Technol. 2023, 57, 22, 8185–8188Publication Date (Web):May 2023Publication History Received6 April 2023Published online22 May inissue 6 June 2023https://doi.org/10.1021/acs.est.3c02476Copyright © 2023 American Chemical SocietyRIGHTS PERMISSIONSArticle Views1709Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (2 MB) Get e-AlertscloseSUBJECTS:Environmental pollution,Nanoparticles,Organic compounds,Plastics,Toxicity e-Alerts

Язык: Английский

Процитировано

36

Simulated gastrointestinal digestion of polylactic acid (PLA) biodegradable microplastics and their interaction with the gut microbiota DOI Creative Commons

Cristina Jiménez‐Arroyo,

Alba Tamargo, Natalia Molinero

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 902, С. 166003 - 166003

Опубликована: Авг. 6, 2023

The accumulation of microplastics (MPs) in the environment as well their presence foods and humans highlight urgent need for studies on effects these particles humans. Polylactic acid (PLA) is most widely used bioplastic food industry medical field. Despite its biodegradability, biocompatibility, "Generally Recognized As Safe" (GRAS) status, recent animal model have shown that PLA MPs can alter intestinal microbiota; however, to date, no been reported possible gut health consequences intake by This work simulates ingestion a realistic daily amount pass through gastrointestinal tract combining INFOGEST method simgi® evaluate human colonic microbiota composition (16S rRNA gene sequencing analysis) metabolic functionality (lactic short-chain fatty acids (SCFA) production). Although did not clearly microbial community homeostasis, increased Bifidobacterium levels tended increase millimetric particles. Furthermore, shifts detected at functional level suggest an alteration metabolism, biotransformation community. Raman spectroscopy field emission scanning electron microscopy (FESEM) characterization revealed morphological changes after gastric phase digestion, adhesion organic matter biofilm, with surface biodegradation, phases. With this evidence emerging use bioplastics, understanding impact potential biodegradation digestion merits critical investigation.

Язык: Английский

Процитировано

24

Beyond the cradle – Amidst microplastics and the ongoing peril during pregnancy and neonatal stages: A holistic review DOI

Indrani Paul,

Pritam Mondal,

Dibyajyoti Haldar

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133963 - 133963

Опубликована: Март 6, 2024

Язык: Английский

Процитировано

18

Modelling microplastic bioaccumulation and biomagnification potential in the Galápagos penguin ecosystem using Ecopath and Ecosim (EwE) with Ecotracer DOI Creative Commons
Karly McMullen, F. Hernán Vargas, Paola Calle

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(1), С. e0296788 - e0296788

Опубликована: Янв. 24, 2024

Bioaccumulation and biomagnification of anthropogenic particles are crucial factors in assessing microplastic impacts to marine ecosystems. Microplastic pollution poses a significant threat iconic often endangered species but examining their tissues gut contents for contaminant analysis via lethal sampling is challenging due ethical concerns animal care restrictions. Incorporating empirical data from prey items fecal matter into models can help trace movement through food webs. In this study, the Galápagos penguin web served as an indicator assess bioaccumulation potential using trophodynamic Ecopath with Ecosim (EwE) modelling Ecotracer. Empirical collected surface seawater near colonies, zooplankton, prey, scat October 2021 were used inform ecosystem model. Multiple scenarios, including 99% elimination rate, employed model sensitivity. Model predictions revealed that microplastics bioaccumulate all predator-prey relationships, highly dependent on rate. It establishes need more research rates different plastics, which critical missing gap current ecotoxicological science. Compared data, efforts underpredicted concentrations zooplankton over-predicted fish. Ultimately, provides novel insights microplastics’ risks. These findings support regional plastic management conserve native endemic Islands Marine Reserve.

Язык: Английский

Процитировано

15

The possible impacts of nano and microplastics on human health: lessons from experimental models across multiple organs DOI

Bernardo Lannes Monteiro Fontes,

Lorena Cristina de Souza e Souza,

Ana Paula Santos da Silva de Oliveira

и другие.

Journal of Toxicology and Environmental Health Part B, Год журнала: 2024, Номер 27(4), С. 153 - 187

Опубликована: Март 22, 2024

The widespread production and use of plastics have resulted in accumulation plastic debris the environment, gradually breaking down into smaller particles over time. Nano-plastics (NPs) microplastics (MPs), defined as than 100 nanometers 5 millimeters, respectively, raise concerns due to their ability enter human body through various pathways including ingestion, inhalation, skin contact. Various investigators demonstrated that these may produce physical chemical damage cells, tissues, organs, disrupting cellular processes, triggering inflammation oxidative stress, impacting hormone neurotransmitter balance. In addition, micro- nano-plastics (MNPLs) carry toxic chemicals pathogens, exacerbating adverse effects on health. magnitude nature are not yet fully understood, requiring further research for a comprehensive risk assessment. Nevertheless, evidence available suggests environment potential uptake causes concern. Urgent measures reduce pollution limit exposure MNPLs necessary safeguard health environment. this review, current knowledge regarding influence is summarized, toxicity mechanisms, pathways, outcomes across multiple organs. critical need additional also emphasized comprehensively assess risks posed by degradation inform strategies addressing emerging environmental challenge. Finally, new directions proposed evaluation gene regulation associated with exposure.

Язык: Английский

Процитировано

15

Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review DOI Open Access

Eliasz Dzierżyński,

Piotr Gawlik, Damian Puźniak

и другие.

Cancers, Год журнала: 2024, Номер 16(21), С. 3703 - 3703

Опубликована: Ноя. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Язык: Английский

Процитировано

15

Effect of micro- and nanoplastic particles on human macrophages DOI Creative Commons

Maike Y. Adler,

Insaf Issoual,

Michael Rückert

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134253 - 134253

Опубликована: Апрель 11, 2024

Micro- and nanoplastics (MNPs) are ubiquitous in the environment, resulting uptake of MNPs by a variety organisms, including humans, leading to particle-cell interaction. Human macrophages derived from THP-1 cell lines take up Polystyrene (PS), widespread plastic. The question therefore arises whether primary human also PS micro- nanobeads (MNBs) how they react this stimulation. Major aim study is visualize validate isolation peripheral blood mononuclear cells (PBMCs) assess impact on macrophages. Uptake PBMCs was examined transmission electron microscopy (TEM), scanning live imaging. In addition, reaction analyzed terms metabolic activity, cytotoxicity, production reactive oxygen species (ROS) macrophage polarization. This first MNBs using TEM Metabolic activity size- concentration-dependent, necrosis ROS were increased. methods demonstrated outline an approach influence MNP exposure help investigating consequences worldwide plastic pollution. among particles which can be found different ecosystems (1). Because their size, enter food chain accumulate large organisms (2). Previous studies already showed cytotoxic effect murine dTHP-1 (3, 4). However more research needed distribution humans. Studying potential health risks model, supports process political decision-making addressing

Язык: Английский

Процитировано

13

Biodegradation of polyethylene (PE), polypropylene (PP), and polystyrene (PS) microplastics by floc-forming bacteria, Bacillus cereus strain SHBF2, isolated from a commercial aquafarm DOI
Shahadat Hossain,

Zuhayra Nasrin Ahmad Shukri,

Khor Waiho

и другие.

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(22), С. 32225 - 32245

Опубликована: Апрель 22, 2024

Язык: Английский

Процитировано

13

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans DOI
Yu Chen, Yuchuan Meng, Guodong Liu

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(21), С. 9071 - 9081

Опубликована: Май 15, 2024

Little research exists on the magnitude, variability, and uncertainty of human exposure to airborne micro- nanoplastics (AMNPs), despite their critical role in MNPs. We probabilistically estimate global intake AMNPs through three main pathways: indoor inhalation, outdoor ingestion during meals, for both children adults. The median inhalation AMPs is 1,207.7 (90% CI, 42.5–8.48 × 104) 1,354.7 47.4–9.55 N/capita/day adults, respectively. annual 13.18 mg/capita/a 19.10 which approximately one-fifth one-third mass a standard stamp, assuming consistent daily medians. majority AMP number occurs while deposited meals contributes most terms mass. Furthermore, ANP 9,638.1 N/day (8.23 10–6 μg/d) 5,410.6 (4.62 respectively, compared 5.30 105 (5.79 10–4 6.00 (6.55 via inhalation. Considering increased toxicity smaller MNPs, significant ANPs inhaled warrants great attention. Collaborative efforts are imperative further elucidate combat current MPN risks.

Язык: Английский

Процитировано

11

The time for ambitious action is now: Science-based recommendations for plastic chemicals to inform an effective global plastic treaty DOI Creative Commons
Susanne M. Brander,

Kala Senathirajah,

M Fernández

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 174881 - 174881

Опубликована: Июль 22, 2024

The ubiquitous and global ecological footprint arising from the rapidly increasing rates of plastic production, use, release into environment is an important modern environmental issue. Of concern are risks associated with at least 16,000 chemicals present in plastics, some which known to be toxic, may leach out both during use once exposed conditions, leading human exposure. In response, United Nations member states agreed establish international legally binding instrument on pollution, plastics treaty. resolution acknowledges that treaty should prevent pollution its related impacts, effective prevention requires consideration transboundary nature full life cycle must addressed. As a group scientific experts members Scientists' Coalition for Effective Plastics Treaty, we concur there six essential "pillars" necessary truly reduce allow chemical detoxification across plastics. These include reduction simplification, safe sustainable design chemicals, incentives change, holistic approaches alternatives, just transition equitable interventions, centering rights. There critical need scientifically informed globally harmonized information, transparency, traceability criteria protect public health. right clean, healthy, upheld, thus it crucial scientists, industry, policy makers work concert create future free hazardous contamination.

Язык: Английский

Процитировано

10