Hypertums A−J, bioactive polycyclic polyprenylated acylphloroglucinols with diverse skeletons from Hypericum perforatum L. (St. John's Wort)

Phytochemistry, Год журнала: 2025, Номер unknown, С. 114450 - 114450

Опубликована: Фев. 1, 2025

Язык: Английский

---

Neuroprotective Effect of Nor-Prenylated Acylphloroglucinols from Hypericum perforatum L. (St John’s Wort) in the MPTP-Induced Zebrafish Model

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3096 - 3096

Опубликована: Март 27, 2025

Hypericum perforatum L. (St John's wort) has been widely studied and used for antidepressant treatment, as well as, rarely, featuring in studies on its chemical composition Parkinson's disease (PD) treatment. Five new nor-prenylated acylphloroglucinols with a cyclohexanone core, norperforatums A-E (1-5), together four known analogs [(2R,3R,4S,6R)-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)cyclohexanone (6), hyperscabrin B (7), (2R,3R,4S,6R)-6-methoxycarbonyl-3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)cyclohexanone (8), hyperscabin K (9)], were isolated from the aerial parts of H. perforatum. The structures absolute configurations compounds characterized by multiple spectroscopic means, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ultraviolet visible absorption spectroscopy (UV), infrared (IR), calculated electronic circular dichroism (ECD) data, X-ray signal crystal diffraction. In addition, efficacy these isolations was evaluated against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD zebrafish larvae. Compound 9 had best therapeutic effect, significantly increasing total distance traveled mean speed movement dyskinesia Moreover, it enhanced superoxide dismutase (SOD) activity inhibited reactive oxygen species (ROS) production dose-dependent manner. These results suggest that compound may have ameliorative effects symptoms inhibiting oxidative stress. This study provides insights into treatment PD.

Язык: Английский

---

Role and mechanism of herbal bioactives in treatment of Parkinson disease: A promising therapeutic approach

South African Journal of Botany, Год журнала: 2025, Номер 181, С. 315 - 338

Опубликована: Апрель 25, 2025

Язык: Английский

---

A Machine Learning‐Based Approach for the Prediction of Anticoagulant Activity of Hypericum perforatum L. and Evaluation of Compound Activity

Phytochemical Analysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 17, 2024

ABSTRACT Introduction Hypericum perforatum L. (HPL) is extensively researched domestically and internationally as a medicinal plant. However, no reports of studies related to the anticoagulant activity HPL have been retrieved. The specific bioactive components are unknown. Objective aim this study was develop machine learning (ML) method for rapid prediction in evaluation compound activity. Materials methods. First, an vitro assay developed determination bioactivity various parts HPL. Then, peak areas compounds were integrated using UPLC‐Q‐TOF‐MS analysis. Subsequently, nine independent ML methods two ensemble established predict evaluate contribution compounds. Feature importance scores used models visualization. Results A total 24 shown exhibited superior Molecular docking experiments likewise confirmed result. results show that branches excellent activity, which has previously overlooked. model demonstrated good performance Conclusion accurate reliable, significantly improved efficiency active screening, further exploration area warranted.

Язык: Английский

---

Structurally Diverse Chromane Meroterpenoids from Rhododendron Capitatum with Multifunctional Neuroprotective Effects

Опубликована: Янв. 1, 2024

Язык: Английский

---

Production of elicitor-induced phytochemicals in callus and shoot cultures of Hypericum heterophyllum

South African Journal of Botany, Год журнала: 2024, Номер 177, С. 295 - 304

Опубликована: Дек. 14, 2024

Язык: Английский

---

Structurally diverse chromane meroterpenoids from Rhododendron capitatum with multifunctional neuroprotective effects

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 283, С. 117188 - 117188

Опубликована: Дек. 19, 2024

Язык: Английский

---