Jurnal Kimia Sains dan Aplikasi,
Год журнала:
2024,
Номер
27(10), С. 464 - 469
Опубликована: Сен. 23, 2024
The
issue
of
antibiotic
resistance
by
bacteria
has
been
studied
to
develop
a
new
agent
inhibit
bacterial
activity.
Recent
studies
have
reported
on
nanoparticles
promising
antibacterial
properties.
Zirconium
dioxide
(ZrO2
NPs)
emerged
as
potential
agents
for
gram-negative
bacteria.
Nevertheless,
there
remains
gap
in
research
done
producing
stable
nanoparticles.
Additionally,
it
the
impact
liquid
environment
synthesis
keep
small
size.
In
this
present
work,
ZrO2
NPs
successfully
synthesized
various
liquids
pulse
laser
ablation
using
Nd:YAG
laser.
was
ablated
surface
zirconium
metal
plate
different
media,
such
deionized
water,
ethylene
diamine,
and
chitosan
solution.
Furthermore,
media
used
an
effect
characteristics
their
An
investigation
scanning
electron
microscope
images
reveals
that
solutions
spherical
morphology
with
diameters
measuring
around
24.33
nm,
19.76
15.05
respectively.
solution
against
E.
coli
is
assessed
diameter
inhibition
zone
(DIZ),
which
greater
colloidal
stability
than
other
media.
findings
indicate
size
enhance
ability
growth
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 8, 2024
ABSTRACT
Selenium
nanoparticles
(Se‐NPs)
were
produced
adopting
an
environmentally
benign
green
synthetic
approach
from
the
waste
biomaterial
obtained
apple
peel
extract
(APE).
The
NPs
characterized
through
UV–Visible
spectroscopy
(UV–Vis),
atomic
force
microscopy
(AFM),
Fourier‐transform
infrared
(FT‐IR),
X‐ray
diffraction
(XRD),
field
emission‐scanning
electron
(FE‐SEM),
and
transmission
(TEM).
spectra
exhibited
absorption
peak
λ
max
at
295
nm,
confirming
formation
of
Se‐NPs.
AFM
examination
revealed
roughness
distribution
nanoparticles,
FT‐IR
ascertained
surface‐contained
functional
groups
presence.
XRD
confirmed
crystalline
nature
sample,
FE‐SEM
validated
surface
morphology
size
range
52
to
84
nm.
TEM
demonstrated
spherical
shapes
Se‐NPs
with
a
face‐centered
cubic
crystal
nature,
whereas
analysis
showed
mean
70
minimum
inhibitory
concentration
(MIC)
500
μg
mL
−1
against
Candida
spp
.,
namely,
C.
albicans
,
guilliermondii
ciferrii
their
anti‐fungal
activity
in
control
minor
statistical
difference
(
p
<
0.05)
dissemination
zones
inhibition
for
treatment
these
fungi.
effects
on
MexA
gene
expression
efflux
pump
role
gene's
down
regulation
treated
fungal
strains.
multi‐drug
resistant
microbes.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(4)
Опубликована: Март 3, 2025
ABSTRACT
Cancer
is
a
significant
global
public
health
concern,
being
the
second
leading
cause
of
mortality,
accounting
for
one
in
six
cases
worldwide.
Researchers
have
employed
various
approaches
cancer
treatment,
with
nanobiotechnology
emerging
as
standout
technique
developing
anticancer
agents.
This
study
assessed
activity
chitosan
(CS)‐coated
gold
nanoparticles
(AuNPs)
and
combination
AuNPs–papain
(Pap)–folic
acid
(FA)
nanomaterial
platforms
against
Michigan
Foundation‐7
(MCF‐7)
cell
lines.
A
range
methods,
including
ultraviolet–visible
(UV–Vis),
Fourier
transform
infrared
(FTIR),
scanning
electron
microscopy
(SEM),
transmission
(TEM),
X‐ray
diffraction
(XRD),
energy‐dispersive
spectroscopy
(EDS),
zeta
potential,
were
used
to
characterize
prepared
nanomaterials.
AuNPs
AuNPs–Pap–FA
exhibited
UV–Vis
absorption
at
525
558
nm,
respectively.
In
XRD
test,
peaks
found
32°,
39°,
45°,
65°,
78.5°,
AuNPs–CS–Pap–FA
identified
29,
37°,
78.5°.
SEM
revealed
irregularly
dispensed
oval
shapes
AuNPs.
TEM
images
confirmed
shape
before
after
coating
Pap
FA.
The
mean
diameter
was
15
AuNPs–CS–Pap–FA,
it
22.5
nm.
Acridine
orange–ethidium
bromide
(AO/EB)
staining,
flow
cytometry
assay,
2,2‐diphenyl‐1‐picrylhydrazyl
(DPPH),
vitro
hemolysis
assays
conducted.
maximum
scavenging
observed
reaching
up
90%.
hemolytic
rate
low
concentrations
(3.12,
6.25,
12.5
μg
mL
−1
)
within
permissible
levels.
concentration
100
reduced
viability
MCF‐7
cells
10%
when
compared
nontreated
cells.
highest
expression
caspase‐8
achieved
treating
line
AuNPs–CS–Pap–FA.
nanopreparation
remarkable
holds
promise
potential
candidate
further
development
towards
clinical
applications
an
agent.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 13, 2024
Abstract
Doxycycline
(Doxy)
is
a
tetracycline
antibiotic
with
potent
antibacterial
activity
against
broad
range
of
bacteria.
Using
nanotechnology
one
feasible
way
to
increase
the
antibiotics’
ability
penetrate
body
and
their
effectiveness.
In
this
work,
we
report
formation
stable
green
synthesized
silver
nanoparticles
(AgNPs)
by
chitosan
Doxy
nanocomposite
for
first
time.
The
obtained
were
characterized
transmission
electron
microscopy
(TEM),
zeta-potential,
UV-Visible
spectroscopy
four
transform
infrared
(FTIRs).
effect
doxy,
AgNPs
doxy/AgNPs
determined
on
Gram-positive
Staphylococcus
aureus
,
Streptococcus
mutans
Gram-negative
Escherichia
coli
Klebsiella
pneumonia
.
This
combined
therapeutic
agent
restored
susceptibility
doxy
showed
an
tested
has
absorption
peak
at
445
nm,
mixing
causes
all
absorptions
red
shift
broadening
in
surface
plasmon
resonance
(SPR)
show
slight
particle
size
from
12
±
2
nm
14
high
stability
as
zeta
potential
was
29
mv
48.5mv
Doxy/AgNPs
respectively.
found
be
twice
free
suggesting
synergistic
interaction
between
two
components.
conclusion,
synergy
quite
promising
resistant
strains.
These
results
highlight
boost
efficacy
doxycycline.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12257 - 12286
Опубликована: Ноя. 1, 2024
Bio-based
synthesis
of
metallic
nanoparticles
has
garnered
much
attention
in
recent
times
owing
to
their
non-toxic,
environmentally
friendly,
and
cost-effective
nature.
PLoS ONE,
Год журнала:
2024,
Номер
19(9), С. e0310997 - e0310997
Опубликована: Сен. 24, 2024
The
increasing
prevalence
of
multi-drug
resistance
in
pathogenic
bacteria
has
rendered
antibiotics
ineffective,
necessitating
the
exploration
alternative
antibacterial
approaches.
Consequently,
research
efforts
have
shifted
towards
developing
new
and
improving
efficacy
existing
ones.
In
present
study,
novel
core
shell
graphene
oxide@platinum
nanoparticles
(GRO@Pt-NPs)
their
unchanging
form
been
synthesized
using
two-step
pulsed
laser
ablation
liquid
(PLAL)
technique.
first
step
involved
target
to
create
(GRO-NPs),
followed
by
GRO-NPs
inside
platinum
(Pt-NPs).
To
characterize
nanoparticles,
various
methods
were
employed,
including
UV-VIS,
transmission
electron
microscopy
(TEM),
energy
dispersive
X-ray
(EDX),
mapping
tests,
diffraction
(XRD).
anti-bacterial
anti-biofilm
properties
investigated.
TEM
data
confirm
creation
GRO@Pt-NPs.
average
particle
size
was
11
nm
for
GRO-NPs,
14
Pt-NPs,
26
results
demonstrate
that
created
GRO@Pt-NPs
strong
properties.
This
pattern
is
mostly
produced
through
accumulation
on
bacterial
surface
Klebsiella
pneumoniae
(
K
.
)
Enterococcus
faecium
E
).
inhibition
zones
against
when
used
alone
found
be
11.80
mm
11.50
mm,
respectively.
For
20.50
16.50
utilization
resulted
a
significant
increase
these
values,
with
inhibitory
rates
25.50
20.45
more
potent
core–shell
structure
than
or
Pt-NPs
alone.
current
work
uses,
time,
fast
effective
technique
synthesize
PLAL
method,
preparation
high
clinical
potential
prospective
use
as
an
agent.
