Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review

American Journal of Clinical Nutrition, Год журнала: 2023, Номер 117(6), С. 1288 - 1305

Опубликована: Апрель 8, 2023

Язык: Английский

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Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 4215 - 4240

Опубликована: Сен. 1, 2024

Angiotensin-converting enzyme 2 receptors (ACE2R) are requisite to enter the host cells for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ACE2R is constitutive and functions as a type I transmembrane metallo-carboxypeptidase in renin-angiotensin system (RAS). On thyroid follicular cells, allows SARS-CoV-2 invade gland, impose cytopathic effects produce endocrine abnormalities, including stiff back, neck pain, muscle ache, lethargy, enlarged, inflamed gland COVID-19 patients. Further damage perpetuated by sudden bursts of pro-inflammatory cytokines, which suggestive life-threatening known "cytokine storm". IL-1β, IL-6, IFN-γ, TNF-α identified key orchestrators cytokine storm. These inflammatory mediators upregulate transcriptional turnover nuclear factor-kappa B (NF-κB), Janus kinase/signal transducer activator transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), paving pathway storm-induced dysfunctions euthyroid sick syndrome, autoimmune diseases, thyrotoxicosis Targeted therapies with corticosteroids (dexamethasone), JAK inhibitor (baricitinib), nucleotide analogue (remdesivir) N-acetyl-cysteine have demonstrated effectiveness terms attenuating severity frequency dysfunctions, morbidity mortality Here, we review pathogenesis storms mechanisms pathways that establish connection between disorder COVID-19. Moreover, cross-talk interactions signalling therapeutic strategies address COVID-19-associated diseases also discussed herein.

Язык: Английский

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Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

iScience, Год журнала: 2021, Номер 25(1), С. 103672 - 103672

Опубликована: Дек. 20, 2021

Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized (Cohort 1) of 25 in the same samples. Combining microRNA (miRNA) measurements allowed for discrimination severe cases greater accuracy than using miRNA or alone. Severity group-specific associations between miRNAs COVID-19-associated (e.g., IL6, CCL20) clinical hallmarks neutrophilia, hypoalbuminemia) separated but Analysis an independent cohort 108 a center 2) demonstrated feasibility CC/miRNA profiling leftover hospital blood samples profiles, revealed CCL20, IL10, miR-451a as key correlates fatal COVID-19. These findings highlight that systemic miRNA/CC networks underpin

Язык: Английский

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The short-term follow-up of patients with diabetes mellitus presenting with COVID-19

Journal of Medicine and Life, Год журнала: 2025, Номер 18(2), С. 116 - 124

Опубликована: Фев. 1, 2025

The COVID-19 pandemic has disproportionately affected individuals with diabetes mellitus (DM), significantly increasing their risk of adverse outcomes. This retrospective study aimed to explore the underlying factors contributing heightened vulnerability DM severe COVID-19. We reviewed medical records patients diagnosed from August 2020 2022 and identified 60 equally divided into two groups. Group A (n = 30) included those an associated infection, while B served as control group without a infection. Inflammatory biomarkers, venous blood glucose levels, other parameters were assessed at hospital admission again after 14-day treatment period. Statistical analysis confirmed strong association between In treated Empagliflozin, correlations observed IL-1, TNF-alpha, IL-6, levels. Patients in did not show significant improvements inflammatory markers or control. contrast, first group, better interleukin levels demonstrated, suggesting higher success rate for that treatment. Our findings indicate Empagliflozin had limited efficacy managing long-term diabetes-related complications, it might offer benefits acute phase illness.

Язык: Английский

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Interplay of host and viral factors in inflammatory pathway mediated cytokine storm during RNA virus infection

Current Research in Immunology, Год журнала: 2023, Номер 4, С. 100062 - 100062

Опубликована: Янв. 1, 2023

RNA viruses always have been a serious concern for human health by causing several outbreaks, often pandemics. The excessive mortality and deaths associated with the outbreaks caused these were due to induction of pro-inflammatory cytokines leading cytokine storm. Cytokines are important cell-to-cell communication maintain cell homeostasis. Disturbances this homeostasis can lead intricate chain reactions resulting in massive release cytokines. This could severe self-reinforcement feedback processes, which eventually cause systemic harm, multiple organ failure, or death. Multiple inflammation-associated pathways involved production its regulation. Different induce through interplay their viral factors host proteins miRNAs regulating pathways. review will discuss that play an role regulation storm possible therapeutic potential molecules treatment challenges clinical translation.

Язык: Английский

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SARS-CoV-2 triggered relapse of multiple sclerosis

Clinical Neurology and Neurosurgery, Год журнала: 2022, Номер 215, С. 107210 - 107210

Опубликована: Март 14, 2022

Язык: Английский

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miRNAs, from Evolutionary Junk to Possible Prognostic Markers and Therapeutic Targets in COVID-19

Viruses, Год журнала: 2021, Номер 14(1), С. 41 - 41

Опубликована: Дек. 27, 2021

The COVID-19 pandemic has been a public health issue around the world in last few years. Currently, there is no specific antiviral treatment to fight disease. Thus, it essential highlight possible prognostic predictors that could identify patients with high risk of developing complications. Within this framework, miRNA biomolecules play vital role genetic regulation various genes, principally, those related pathophysiology Here, we review interaction host and viral microRNAs molecular cellular elements potentiate main pulmonary, cardiac, renal, circulatory, neuronal complications patients. miR-26a, miR-29b, miR-21, miR-372, miR-2392, among others, have associated exacerbation inflammatory process, increasing cytokine storm. In addition, increased expression miR-15b, -199a, -491 are prognosis disease, miR-192 miR-323a were identified as clinical mortality admitted intensive care unit. Finally, address miR-29, miR-122, miR-155, miR-200, therapeutic targets. However, more studies required confirm these findings.

Язык: Английский

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Tangled quest of post-COVID-19 infection-caused neuropathology and what 3P nano-bio-medicine can solve?

The EPMA Journal, Год журнала: 2022, Номер 13(2), С. 261 - 284

Опубликована: Июнь 1, 2022

Язык: Английский

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Study on Potential Differentially Expressed Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics and Next-Generation Sequencing Data Analysis

Biomedicines, Год журнала: 2023, Номер 11(12), С. 3109 - 3109

Опубликована: Ноя. 21, 2023

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with reduced quality of life and earlier mortality, but its pathogenesis key genes are still unclear. In this investigation, bioinformatics was used to deeply analyze the IPF related genes, so as investigate potential molecular provide guidance for clinical treatment. Next-generation sequencing dataset GSE213001 obtained from Gene Expression Omnibus (GEO), differentially expressed (DEGs) were identified between normal control group. The DEGs group screened DESeq2 package R language. Ontology (GO) REACTOME pathway enrichment analyses performed. Using g:Profiler, function Then, protein-protein interaction (PPI) network constructed via Integrated Interactions Database (IID) database. Cytoscape Network Analyzer identify hub genes. miRNet NetworkAnalyst databaseswereused construct targeted microRNAs (miRNAs), transcription factors (TFs), small drug molecules. Finally, receiver operating characteristic (ROC) curve analysis validate A total 958 out in study, including 479 up regulated down Most significantly enriched response stimulus, GPCR ligand binding, microtubule-based process, defective GALNT3 causes HFTC. combination results PPI network, miRNA-hub gene regulatory TF-hub LRRK2, BMI1, EBP, MNDA, KBTBD7, KRT15, OTX1, TEKT4, SPAG8, EFHC2 selected. Cyclothiazide rotigotinethe predicted molecules Our findings will contribute identification biomarkers novel strategies treatment IPF, strategy therapy.

Язык: Английский

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Identification of miR-29a as a novel biomarker for lumpy skin disease virus exposure in cattle

Virulence, Год журнала: 2024, Номер 15(1)

Опубликована: Март 25, 2024

Micro RNAs (miRNAs) have been implicated in the regulation of maturation, proliferation, differentiation, and activation immune cells. In this study, we demonstrated that miR-29a antagonizes IFN-γ production at early times post-LSDV infection cattle. was predicted to target upstream regulators, its inhibition resulted enhanced sensitized peripheral blood mononuclear cells (PBMCs). Further, stimulation PBMCs with LSDV antigen exhibited lower levels miR-29a, concomitant a potent cell-mediated response (CMI), characterized by an increase LSDV-specific CD8+ T cell counts IFN-γ, which eventually facilitated virus clearance. addition, few immunocompromised cattle (developed secondary ~ 6 months) failed mount response, were shown maintain higher levels. Furthermore, as compared crossbred cattle, from Rathi (a native Indian breed) animals along IFN-γ. Finally, analysed ≥ 60% decrease expression correlated CMI response. conclusion, is involved antagonizing LSDV-infected may serve novel biomarker for acute phase infection, well predicting functionality more against than

Язык: Английский

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