SSRN Electronic Journal,
Год журнала:
2022,
Номер
unknown
Опубликована: Янв. 1, 2022
Sepsis-induced
cardiomyopathy
(SIC)
is
a
common
complication
of
sepsis
and
the
main
reason
for
high
mortality
in
patients.
More
recent
studies
have
indicated
that
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
signaling
plays
protective
role
SIC,
activation
Nrf2
can
reduce
sepsis-related
myocardial
injury.
As
potent
activator
Nrf2,
Omaveloxolone
(Omav)
pivotal
defending
against
oxidative
stress
inflammatory
response.
Thus,
we
examined
efficacy
Omav
SIC.
In
present
study,
mice
were
injected
intraperitoneally
with
single
dose
LPS
(10
mg/kg)
12
hours
to
induce
The
data
our
study
administration
significantly
increased
survival
rate
improved
cardiac
injury
dysfunction
LPS-induced
addition,
reduced
SIC-related
stress,
response
cardiomyocyte
apoptosis
vivo
vitro.
Moreover,
activate
pathway
knockdown
abolished
Omav-mediated
cardioprotective
effects.
conclusion,
has
potential
treating
SIC
via
pathway.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2023,
Номер
2023, С. 1 - 23
Опубликована: Янв. 14, 2023
Cardiotoxicity
linked
to
doxorubicin
(DOX)
is
primarily
caused
by
inflammation,
oxidative
stress,
and
apoptosis.
The
role
of
tubeimoside
I
(TBM)
in
DOX-induced
cardiotoxicity
remains
ambiguous,
despite
growing
evidence
that
it
could
reduce
apoptosis
various
diseases.
This
study
was
designed
investigate
the
TBM
uncover
underlying
mechanisms.
H9c2
cell
line
C57BL/6
mice
were
used
construct
an
vitro
vivo
model
myocardial
injury,
respectively.
We
observed
DOX
treatment
provoked
cardiomyocyte
apoptosis,
which
significantly
alleviated
administration.
Mechanistically,
attenuated
downregulation
sirtuin
3
(SIRT3),
SIRT3
inhibition
abrogated
beneficial
effects
both
vivo.
In
conclusion,
eased
increasing
expression
SIRT3,
suggesting
holds
great
promise
for
treating
cardiac
injury.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 30, 2024
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
human
mortality
worldwide.
Despite
Western
medicine
having
made
encouraging
results
in
clinical
management
CVD,
morbidity,
mortality,
and
disability
rates
remain
high.
Modern
pharmacology
has
confirmed
that
traditional
Chinese
(TCM),
characterized
by
its
multi-component,
multi-target,
integrity,
plays
a
positive
important
role
prevention
treatment
various
CVDs
China,
which
notable
advantages
stabilizing
disease,
improving
heart
function,
enhancing
quality
life.
Importantly,
TCM
gradually
being
accepted
international
community
due
to
low
cost,
high
safety,
versatile
bioactivity,
toxicity.
Unfortunately,
comprehensive
studies
on
therapeutic
effect
CVD
mechanisms
are
very
limited,
may
restrict
application
CVD.
Therefore,
this
review
performed
analyze
pathogenesis
including
inflammatory
response,
oxidative
stress,
mitochondrial
dysfunction,
pyroptosis,
ferroptosis,
dysbiosis
gut
microbiota,
etc.
Moreover,
we
summarized
latest
progress
(formulas,
extracts,
compounds)
curing
according
published
literature
from
2018
2023,
as
well
evidence.
In
conclusion,
expected
provide
useful
information
reference
for
further
drug
development
